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Endocrine
Published in: Endocrine 2/2018

01-05-2018 | Original Article

Impact of maternal thyroid autoantibodies positivity on the risk of early term birth: Ma’anshan Birth Cohort Study

Authors: Yan Han, Lei-Jing Mao, Xing Ge, Kun Huang, Shuang-Qin Yan, Ling-Ling Ren, Shu-Qing Hong, Hui Gao, Jie Sheng, Yuan-Yuan Xu, Wei-Jun Pan, Peng Zhu, Jia-Hu Hao, De-Fa Zhu, Fang-Biao Tao

Published in: Endocrine | Issue 2/2018

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Abstract

Purpose

We aim to investigate associations of maternal serum anti-thyroperoxidase autoantibody (TPOAb) with duration of gestation. We aim to investigate whether maternal TPOAb positivity is associated with the risk of premature or early term birth.

Methods

This was a prospective birth cohort study performed in an iodine sufficient area of China. Serum samples were collected from 2931 women at both the first and second trimesters of pregnancy. Thyrotropin (TSH), free thyroxine (FT4), and TPOAb levels were measured. Data on gestational age at birth was obtained from delivery records.

Results

The prevalence of early term birth was 23.8%, while the prevalence of premature birth was 4.2%. The prevalence of TPOAb positivity was 12.1% in the first trimester and was 7.2% in the second trimester. Gestational age at birth was inversely associated with lgTPOAb both in the first trimester (β, −0.283, 95% CI −0.408, −0.158; P < 0.001) and in the second trimester (β, −0.174, 95% CI −0.319, −0.030; P = 0.018), after adjustment for potential confounding factors. There was a positive association of TPOAb positivity with the risk of early term birth both in the first (OR = 1.691, 95% CI 1.302, 2.197) and second trimesters (OR = 1.644, 95% CI 1.193, 2.264), after adjustment for potential confounding factors. TPOAb positivity in the second trimester was associated with a 1.863-fold higher risk of premature birth (OR = 1.863, 95% CI 1.009, 3.441), after adjustment for potential confounding factors.

Conclusions

Our results show that TPOAb is associated with shorter duration of gestation and with higher risk of premature and early term birth.
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Metadata
Title
Impact of maternal thyroid autoantibodies positivity on the risk of early term birth: Ma’anshan Birth Cohort Study
Authors
Yan Han
Lei-Jing Mao
Xing Ge
Kun Huang
Shuang-Qin Yan
Ling-Ling Ren
Shu-Qing Hong
Hui Gao
Jie Sheng
Yuan-Yuan Xu
Wei-Jun Pan
Peng Zhu
Jia-Hu Hao
De-Fa Zhu
Fang-Biao Tao
Publication date
01-05-2018
Publisher
Springer US
Published in
Endocrine / Issue 2/2018
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-018-1576-6

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