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01-06-2017 | Original Article

Follicle stimulating hormone, its novel association with sex hormone binding globulin in men and postmenopausal women

Authors: Ningjian Wang, Kun Zhang, Bing Han, Qin Li, Yi Chen, Chunfang Zhu, Yingchao Chen, Fangzhen Xia, Hualing Zhai, Boren Jiang, Zhoujun Shen, Yingli Lu

Published in: Endocrine | Issue 3/2017

Abstract

Purpose

Follicle stimulating hormone plays direct roles in a variety of nongonadal tissues and sex hormone binding globulin is becoming the convergence of the crosstalk among metabolic diseases. However, no studies have explored the association between follicle stimulating hormone and sex hormone binding globulin. We aimed to study this association among men and women.

Methods

SPECT-China is a population-based study conducted since 2014. This study included 4206 men and 2842 postmenopausal women. Collected serum was assayed for gonadotropins, sex hormone binding globulin, sex hormones etc. Regression analyses were performed to assess the relationship between sex hormone binding globulin and follicle stimulating hormone and other variables including metabolic factors, thyroid function and sex hormones. Treatment with follicle stimulating hormone at different concentrations of 0, 5, 50 and 100 IU/L for 24 h was performed in HepG2 cells.

Results

In Spearman correlation, sex hormone binding globulin was significantly correlated with FSH, triglycerides, thyroxins, body mass index and blood pressure in men and postmenopausal women (all P < 0.05). In regression analyses, follicle stimulating hormone was a significant predictor of sex hormone binding globulin in men and postmenopausal women (P < 0.05), independent of above variables. Follicle stimulating hormone induced sex hormone binding globulin expression in a dose-dependent fashion in HepG2 cells.

Conclusion

Serum follicle stimulating hormone levels were positively associated with circulating sex hormone binding globulin levels in men and postmenopausal women. This association is independent of age, insulin resistance, hepatic function, lipid profile, thyroid function, adiposity, blood pressure, and endogenous sex hormones.

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Title: Follicle stimulating hormone, its novel association with sex hormone binding globulin in men and postmenopausal women
Authors: Ningjian Wang
Kun Zhang
Bing Han
Qin Li
Yi Chen
Chunfang Zhu
Yingchao Chen
Fangzhen Xia
Hualing Zhai
Boren Jiang
Zhoujun Shen
Yingli Lu
Publication date: 01-06-2017
Publisher: Springer US
Published in: Endocrine / Issue 3/2017
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-017-1272-y

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Follicle stimulating hormone, its novel association with sex hormone binding globulin in men and postmenopausal women

Abstract

Purpose

Methods

Results

Conclusion

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Abstract

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Conclusion

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