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01-03-2017 | Editorial

Understanding and predicting fracture risk in acromegaly

Authors: Natasha M. Appelman-Dijkstra, Nienke R. Biermasz

Published in: Endocrine | Issue 3/2017

Excerpt

Acromegaly is a rare endocrine disease that has been shown to be associated with an increased risk of vertebral fractures even in the presence of a relatively normal bone mineral density (BMD). These fractures do not only occur during the period of active acromegaly, but it has been shown that after remission of acromegaly patients continue to have an increased risk for new and progression of vertebral fractures, see a recent review [1]. …

K.M. Claessen, G. Mazziotti, N.R. Biermasz, A. Giustina, Bone and joint disorders in acromegaly. Neuroendocrinology 103(1), 86–95 (2016). (review)CrossRefPubMed

T. Ueland, E.N. Ebbesen, J.S. Thomsen, L. Mosekilde, K. Brixen, A. Flyvbjerg, J. Bollerslev, Decreased trabecular bone biomechanical competence, apparent density, IGF-II and IGFBP-5 content in acromegaly. Eur. J. Clin. Invest. 32, 122–128 (2002)CrossRefPubMed

M. Madeira, L.V. Neto, F. de Paula Paranhos Neto, I.C. Barbosa Lima, L.M. Carvalho de Mendonça, M.R. Gadelha, M.L. Fleiuss de Farias, Acromegaly has a negative influence on trabecular bone, but not on cortical bone, as assessed by high-resolution peripheral quantitative computed tomography. J. Clin. Endocrinol. Metab. 98, 1734–1741 (2013)CrossRefPubMed

F. Maffezzoni, M. Maddalo, S. Frara, M. Mezzone, I. Zorza, F. Baruffaldi, F. Doglietto, G. Mazziotti, G. Maroldi, A. Giustina, High-resolution-cone beam tomography analysis of bone microarchitecture in patients with acromegaly and radiological vertebral fractures. Endocrine 54:532–542 (2016). doi:10.1007/s12020-016-1078-3

E. Valassi, I. Crespo, J. Malouf, J. Llauger, A. Aulinas, A.M. Marín, B. Biagetti, S.M. Webb, Reduction of trabecular and cortical volumetric bone mineral density at the proximal femur in patients with acromegaly. Eur. J. Endocrinol. 174(2), 107–114 (2016).CrossRefPubMed

Title: Understanding and predicting fracture risk in acromegaly
Authors: Natasha M. Appelman-Dijkstra
Nienke R. Biermasz
Publication date: 01-03-2017
Publisher: Springer US
Published in: Endocrine / Issue 3/2017
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-017-1238-0

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