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At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
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Endocrine
Published in: Endocrine 3/2013

01-06-2013 | Review

Methylglyoxal, obesity, and diabetes

Authors: Paulo Matafome, Cristina Sena, Raquel Seiça

Published in: Endocrine | Issue 3/2013

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Abstract

Methylglyoxal (MG) is a highly reactive compound derived mainly from glucose and fructose metabolism. This metabolite has been implicated in diabetic complications as it is a strong AGE precursor. Furthermore, recent studies suggested a role for MG in insulin resistance and beta-cell dysfunction. Although several drugs have been developed in the recent years to scavenge MG and inhibit AGE formation, we are still far from having an effective strategy to prevent MG-induced mechanisms. This review summarizes the mechanisms of MG formation, detoxification, and action. Furthermore, we review the current knowledge about its implication on the pathophysiology and complications of obesity and diabetes.
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Metadata
Title
Methylglyoxal, obesity, and diabetes
Authors
Paulo Matafome
Cristina Sena
Raquel Seiça
Publication date
01-06-2013
Publisher
Springer US
Published in
Endocrine / Issue 3/2013
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-012-9795-8

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