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Clinical & Translational Metabolism
Published in: Clinical Reviews in Bone and Mineral Metabolism 4/2018

01-12-2018 | Fracture

Systemic Bone Loss After Fracture

Authors: Benjamin Osipov, Armaun J. Emami, Blaine A. Christiansen

Published in: Clinical & Translational Metabolism | Issue 4/2018

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Abstract

A history of prior fracture is the most reliable indicator of prospective fracture risk. Increased fracture risk is not confined to the region of the prior fracture but is operant at all skeletal sites, providing strong evidence of systemic bone loss after fracture. Animal and human studies suggest that systemic bone loss begins shortly after fracture and persists for several years in humans. In fact, bone quantity and bone quality may never fully return to their pre-fracture levels, especially in older subjects, demonstrating a need for improved understanding of the mechanisms leading to systemic bone loss after fracture in order to reduce subsequent fracture risk. Although the process remains incompletely understood, mechanical unloading (disuse), systemic inflammation, and hormones that control calcium homeostasis may all contribute to systemic bone loss. Additionally, individual factors can potentially affect the magnitude and time course of systemic bone loss and recovery. The magnitude of systemic bone loss correlates positively with injury severity and age. Men may also experience greater bone loss or less recovery than women after fracture. This review details the current understanding of systemic bone loss following fracture, including possible underlying mechanisms and individual factors that may affect this injury response.
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Metadata
Title
Systemic Bone Loss After Fracture
Authors
Benjamin Osipov
Armaun J. Emami
Blaine A. Christiansen
Publication date
01-12-2018
Publisher
Springer US
Published in
Clinical & Translational Metabolism / Issue 4/2018
Print ISSN: 1534-8644
Electronic ISSN: 2948-2445
DOI
https://doi.org/10.1007/s12018-018-9253-0

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