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01-12-2017 | Original Paper

STAT4 Polymorphisms are Associated with Neuromyelitis Optica Spectrum Disorders

Authors: Ziyan Shi, Qin Zhang, Hongxi Chen, Zhiyun Lian, Ju Liu, Huiru Feng, Xiaohui Miao, Qin Du, Hongyu Zhou

Published in: NeuroMolecular Medicine | Issue 4/2017

Abstract

STAT4 plays a crucial role in the functioning of the innate and adaptive immune cells and has been identified as a susceptibility gene in numerous autoimmune disorders. However, its association with neuromyelitis optica spectrum disorders (NMOSD) remains uncertain. Here, we performed a case–control study to determine whether STAT4 contributed to the risk of NMOSD. We tested five STAT4 SNPs in 233 patients with established NMOSD and 492 healthy controls. Chi-square tests and logistic regression analyses were performed with four genetic models, including allelic, additive, dominant, and recessive models, to identify associations with NMOSD. The results of multiple test comparisons were corrected using the Benjamini and Hochberg false discovery rate (FDR–BH). After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32–2.08, P _corr = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29–2.03, P _corr = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27–2.00, P _corr = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21–1.90, P _corr = 0.004). Identical results were observed in the dominant, recessive, and additive models. In contrast, the G allele of rs7601754 displayed a protective effect against NMOSD (OR = 0.53, 95% CI 0.36–0.76, P _corr = 0.006). Our study indicates that STAT4 polymorphisms are associated with the risk of NMOSD, which provides novel insights into the underlying mechanisms of this disease.

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Title: STAT4 Polymorphisms are Associated with Neuromyelitis Optica Spectrum Disorders
Authors: Ziyan Shi
Qin Zhang
Hongxi Chen
Zhiyun Lian
Ju Liu
Huiru Feng
Xiaohui Miao
Qin Du
Hongyu Zhou
Publication date: 01-12-2017
Publisher: Springer US
Published in: NeuroMolecular Medicine / Issue 4/2017
Print ISSN: 1535-1084
Electronic ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-017-8463-9

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STAT4 Polymorphisms are Associated with Neuromyelitis Optica Spectrum Disorders

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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