Top

Clinical Reviews in Allergy & Immunology

Published in:

Open Access 01-06-2020 | Obesity

Crosstalk Between Mast Cells and Adipocytes in Physiologic and Pathologic Conditions

Authors: Daniel Elieh Ali Komi, Farzaneh Shafaghat, Mark Christian

Published in: Clinical Reviews in Allergy & Immunology | Issue 3/2020

Abstract

Excessive fatty acids and glucose uptake support the infiltration of adipose tissue (AT) by a variety of immune cells including neutrophils, pro-inflammatory M1 macrophages, and mast cells (MCs). These cells promote inflammation by releasing pro-inflammatory mediators. The involvement of MCs in AT biology is supported by their accumulation in the AT of obese individuals along with significantly higher serum levels of MC-derived tryptase. AT-resident MCs under the influence of locally derived adipokines such as leptin become activated and release pro-inflammatory cytokines including TNFα that worsens the inflammatory state. MCs support angiogenesis in AT by releasing chymase and inducing preadipocyte differentiation and also the proliferation of adipocytes through 15-deoxy-delta PGJ2/PPARγ interaction. Additionally, they contribute to the remodeling of the AT extracellular matrix (ECM) and play a role in the recruitment and activation of leukocytes. MC degranulation has been linked to brown adipocyte activation, and evidence indicates an important link between MCs and the appearance of BRITE/beige adipocytes in white AT. Cell crosstalk between MCs and AT-resident cells, mainly adipocytes and immune cells, shows that these cells play a critical role in the regulation of AT homeostasis and inflammation.

Oishi Y, Manabe I (2016) Integrated regulation of the cellular metabolism and function of immune cells in adipose tissue. Clin Exp Pharmacol Physiol 43(3):294–303. https://doi.org/10.1111/1440-1681.12539 CrossRefPubMed

Li M, Yang X, Zhang Y, Chen L, Lu H, Li X, Yin L, Zhi X (2015) Activation of proteaseactivated receptor2 is associated with increased expression of inflammatory factors in the adipose tissues of obese mice. Mol Med Rep 12(4):6227–6234. https://doi.org/10.3892/mmr.2015.4179 CrossRefPubMed

Jo J, Gavrilova O, Pack S, Jou W, Mullen S, Sumner AE, Cushman SW, Periwal V (2009) Hypertrophy and/or hyperplasia: dynamics of adipose tissue growth. PLoS Comput Biol 5(3):e1000324. https://doi.org/10.1371/journal.pcbi.1000324 CrossRefPubMedPubMedCentral

Spencer M, Yang L, Adu A, Finlin BS, Zhu B, Shipp LR, Rasouli N, Peterson CA, Kern PA (2014) Pioglitazone treatment reduces adipose tissue inflammation through reduction of mast cell and macrophage number and by improving vascularity. PLoS One 9(7):e102190. https://doi.org/10.1371/journal.pone.0102190 CrossRefPubMedPubMedCentral

Lu C, Zhao AX, Gao YJ, Lee RM (2011) Modulation of vein function by perivascular adipose tissue. Eur J Pharmacol 657(1–3):111–116. https://doi.org/10.1016/j.ejphar.2010.12.028 CrossRefPubMed

Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259(5091):87–91CrossRef

Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB (1995) The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 95(5):2111–2119. https://doi.org/10.1172/jci117899 CrossRefPubMedPubMedCentral

Divoux A, Moutel S, Poitou C, Lacasa D, Veyrie N, Aissat A, Arock M, Guerre-Millo M, Clement K (2012) Mast cells in human adipose tissue: link with morbid obesity, inflammatory status, and diabetes. J Clin Endocrinol Metab 97(9):E1677–E1685. https://doi.org/10.1210/jc.2012-1532 CrossRefPubMed

Finlin BS, Confides AL, Zhu B, Boulanger MC, Memetimin H, Taylor KW, Johnson ZR, Westgate PM, Dupont-Versteegden EE, Kern PA (2019) Adipose tissue mast cells promote human adipose beiging in response to cold. Sci Rep 9(1):8658. https://doi.org/10.1038/s41598-019-45136-9 CrossRefPubMedPubMedCentral

10.

Bais S, Kumari R, Prashar Y, Gill NS (2017) Review of various molecular targets on mast cells and its relation to obesity: a future perspective. Diabetes Metab Syndr 11(Suppl 2):S1001–s1007. https://doi.org/10.1016/j.dsx.2017.07.029 CrossRefPubMed

11.

Liu J, Divoux A, Sun J, Zhang J, Clement K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP (2009) Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med 15(8):940–945. https://doi.org/10.1038/nm.1994 CrossRefPubMedPubMedCentral

12.

Bao B, Chen YG, Zhang L, Na Xu YL, Wang X, Liu J, Qu W (2013) Momordica charantia (bitter melon) reduces obesity-associated macrophage and mast cell infiltration as well as inflammatory cytokine expression in adipose tissues. PLoS One 8(12):e84075. https://doi.org/10.1371/journal.pone.0084075 CrossRefPubMedPubMedCentral

13.

Dong J, Zhang X, Zhang L, Bian HX, Xu N, Bao B, Liu J (2014) Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKalpha1/SIRT1. J Lipid Res 55(3):363–374. https://doi.org/10.1194/jlr.M038786 CrossRefPubMedPubMedCentral

14.

Komi DEA, Khomtchouk K, Santa Maria PL (2019) A review of the contribution of mast cells in wound healing: involved molecular and cellular mechanisms. Clin Rev Allergy Immunol:1–15. https://doi.org/10.1007/s12016-019-08729-w

15.

Elieh Ali Komi D, Rambasek T, Bielory L (2018) Clinical implications of mast cell involvement in allergic conjunctivitis. Allergy 73(3):528–539. https://doi.org/10.1111/all.13334 CrossRefPubMed

16.

Elieh-Ali-Komi D, Cao Y (2017) Role of mast cells in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis. Clin Rev Allergy Immunol 52(3):436–445. https://doi.org/10.1007/s12016-016-8595-y CrossRefPubMed

17.

Elieh Ali Komi D, Bjermer L (2018) Mast cell-mediated orchestration of the immune responses in human allergic asthma: current insights. Clin Rev Allergy Immunol 56:234–247. https://doi.org/10.1007/s12016-018-8720-1 CrossRef

18.

Komi DEA, Rambasek T, Wohrl S (2018) Mastocytosis: from a molecular point of view. Clin Rev Allergy Immunol 54(3):397–411. https://doi.org/10.1007/s12016-017-8619-2 CrossRefPubMed

19.

Karimi A, Shahrooz R, Hobbenagh R, Delirezh N, Amani S, Garssen J, Mortaz E, M Adcock I (2020) Histological evidence for therapeutic induction of angiogenesis using mast cells and platelet-rich plasma within a bioengineered scaffold following rat hindlimb ischemia. Cell J 21(4):391–400. https://doi.org/10.22074/cellj.2020.6287 CrossRefPubMed

20.

Ghigliotti G, Barisione C, Garibaldi S, Fabbi P, Brunelli C, Spallarossa P, Altieri P, Rosa G, Spinella G, Palombo D, Arsenescu R, Arsenescu V (2014) Adipose tissue immune response: novel triggers and consequences for chronic inflammatory conditions. Inflammation 37(4):1337–1353. https://doi.org/10.1007/s10753-014-9914-1 CrossRefPubMedPubMedCentral

21.

Elieh Ali Komi D, Ribatti D (2019) Mast cell-mediated mechanistic pathways in organ transplantation. Eur J Pharmacol 857:172458. https://doi.org/10.1016/j.ejphar.2019.172458 CrossRefPubMed

22.

Poglio S, De Toni-Costes F, Arnaud E, Laharrague P, Espinosa E, Casteilla L, Cousin B (2010) Adipose tissue as a dedicated reservoir of functional mast cell progenitors. Stem Cells 28(11):2065–2072. https://doi.org/10.1002/stem.523 CrossRefPubMed

23.

Achari AE, Jain SK (2017) Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction. Int J Mol Sci 18(6). https://doi.org/10.3390/ijms18061321

24.

Chmelar J, Chung KJ, Chavakis T (2013) The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance. Thromb Haemost 109(3):399–406. https://doi.org/10.1160/th12-09-0703 CrossRefPubMed

25.

Guo H, Bazuine M, Jin D, Huang MM, Cushman SW, Chen X (2013) Evidence for the regulatory role of lipocalin 2 in high-fat diet-induced adipose tissue remodeling in male mice. Endocrinology 154(10):3525–3538. https://doi.org/10.1210/en.2013-1289 CrossRefPubMedPubMedCentral

26.

Hasegawa Y, Ikeda K, Chen Y, Alba DL, Stifler D, Shinoda K, Hosono T, Maretich P, Yang Y, Ishigaki Y, Chi J, Cohen P, Koliwad SK, Kajimura S (2018) Repression of adipose tissue fibrosis through a PRDM16-GTF2IRD1 complex improves systemic glucose homeostasis. Cell Metab 27(1):180–194.e186. https://doi.org/10.1016/j.cmet.2017.12.005 CrossRefPubMedPubMedCentral

27.

Radzicka S, Pietryga M, Iciek R, Brazert J (2018) The role of visfatin in pathogenesis of gestational diabetes (GDM). Ginekol Pol 89(9):518–521. https://doi.org/10.5603/GP.a2018.0088 CrossRefPubMed

28.

Koch A, Weiskirchen R (2018) Visfatin serum levels predict mortality in critically ill patients. Dis Markers 2018:7315356. https://doi.org/10.1155/2018/7315356 CrossRefPubMedPubMedCentral

29.

Apostolopoulos V, de Courten MP, Stojanovska L, Blatch GL, Tangalakis K, de Courten B (2016) The complex immunological and inflammatory network of adipose tissue in obesity. Mol Nutr Food Res 60(1):43–57. https://doi.org/10.1002/mnfr.201500272 CrossRefPubMed

30.

Zelechowska P, Agier J, Rozalska S, Wiktorska M, Brzezinska-Blaszczyk E (2018) Leptin stimulates tissue rat mast cell pro-inflammatory activity and migratory response. Inflamm Res 67(9):789–799. https://doi.org/10.1007/s00011-018-1171-6 CrossRefPubMedPubMedCentral

31.

Altintas MM, Nayer B, Walford EC, Johnson KB, Gaidosh G, Reiser J, De La Cruz-Munoz N, Ortega LM, Nayer A (2012) Leptin deficiency-induced obesity affects the density of mast cells in abdominal fat depots and lymph nodes in mice. Lipids Health Dis 11:21. https://doi.org/10.1186/1476-511x-11-21 CrossRefPubMedPubMedCentral

32.

Wei Q, Lee JH, Wang H, Bongmba OYN, Wu CS, Pradhan G, Sun Z, Chew L, Bajaj M, Chan L, Chapkin RS, Chen MH, Sun Y (2017) Adiponectin is required for maintaining normal body temperature in a cold environment. BMC Physiol 17(1):8. https://doi.org/10.1186/s12899-017-0034-7 CrossRefPubMedPubMedCentral

33.

Anderson EK, Gutierrez DA, Hasty AH (2010) Adipose tissue recruitment of leukocytes. Curr Opin Lipidol 21(3):172–177. https://doi.org/10.1097/MOL.0b013e3283393867 CrossRefPubMedPubMedCentral

34.

Satish M, Saxena SK, Agrawal DK (2019) Adipokine dysregulation and insulin resistance with atherosclerotic vascular disease: metabolic syndrome or independent sequelae? J Cardiovasc Transl Res. https://doi.org/10.1007/s12265-019-09879-0 CrossRef

35.

Ortega-Senovilla H, de Oya M, Garces C (2019) Relationship of NEFA concentrations to RBP4 and to RBP4/retinol in prepubertal children with and without obesity. J Clin Lipidol 13(2):301–307. https://doi.org/10.1016/j.jacl.2019.01.006 CrossRefPubMed

36.

Tabak O, Simsek G, Erdenen F, Sozer V, Hasoglu T, Gelisgen R, Altunoglu E, Muderrisoglu C, Senyigit A, Uzun H (2017) The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome. Arch Endocrinol Metab 61(6):515–523. https://doi.org/10.1590/2359-3997000000289 CrossRefPubMed

37.

Franz K, Ost M, Otten L, Herpich C, Coleman V, Endres AS, Klaus S, Muller-Werdan U, Norman K (2018) Higher serum levels of fibroblast growth factor 21 in old patients with cachexia. Nutrition 63-64:81–86. https://doi.org/10.1016/j.nut.2018.11.004 CrossRefPubMed

38.

Mutsnaini L, Kim CS, Kim J, Joe Y, Chung HT, Choi HS, Roh E, Kim MS, Yu R (2019) Fibroblast growth factor 21 deficiency aggravates obesity-induced hypothalamic inflammation and impairs thermogenic response. Inflamm Res 68(5):351–358. https://doi.org/10.1007/s00011-019-01222-2 CrossRefPubMed

39.

Benomar Y, Taouis M (2019) Molecular mechanisms underlying obesity-induced hypothalamic inflammation and insulin resistance: pivotal role of resistin/TLR4 pathways. Front Endocrinol 10:140. https://doi.org/10.3389/fendo.2019.00140 CrossRef

40.

Sundaram S, Yan L (2019) Adipose-specific monocyte chemotactic protein-1 deficiency reduces pulmonary metastasis of Lewis lung carcinoma in mice. Anticancer Res 39(4):1729–1738. https://doi.org/10.21873/anticanres.13279 CrossRefPubMed

41.

Khadir A, Kavalakatt S, Madhu D, Hammad M, Devarajan S, Tuomilehto J, Tiss A (2018) Fetuin-A levels are increased in the adipose tissue of diabetic obese humans but not in circulation. Lipids Health Dis 17(1):291. https://doi.org/10.1186/s12944-018-0919-x CrossRefPubMedPubMedCentral

42.

Jialal I, Pahwa R (2019) Fetuin-A is also an adipokine. Lipids Health Dis 18(1):73. https://doi.org/10.1186/s12944-019-1021-8 CrossRefPubMedPubMedCentral

43.

Makki K, Froguel P, Wolowczuk I (2013) Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines. ISRN Inflamm 2013:139239. https://doi.org/10.1155/2013/139239 CrossRefPubMedPubMedCentral

44.

Ohashi K, Parker JL, Ouchi N, Higuchi A, Vita JA, Gokce N, Pedersen AA, Kalthoff C, Tullin S, Sams A, Summer R, Walsh K (2010) Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem 285(9):6153–6160. https://doi.org/10.1074/jbc.M109.088708 CrossRefPubMed

45.

Raajendiran A, Ooi G, Bayliss J, O’Brien PE, Schittenhelm RB, Clark AK, Taylor RA, Rodeheffer MS, Burton PR, Watt MJ (2019) Identification of metabolically distinct adipocyte progenitor cells in human adipose tissues. Cell Rep 27(5):1528–1540.e1527. https://doi.org/10.1016/j.celrep.2019.04.010 CrossRefPubMed

46.

Keipert S, Jastroch M (2014) Brite/beige fat and UCP1-is it thermogenesis? Biochim Biophys Acta 1837(7):1075–1082. https://doi.org/10.1016/j.bbabio.2014.02.008 CrossRefPubMed

47.

Giordano A, Smorlesi A, Frontini A, Barbatelli G, Cinti S (2014) White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ. Eur J Endocrinol 170(5):R159–R171. https://doi.org/10.1530/eje-13-0945 CrossRefPubMed

48.

Wu J, Bostrom P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerback S, Schrauwen P, Spiegelman BM (2012) Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150(2):366–376. https://doi.org/10.1016/j.cell.2012.05.016 CrossRefPubMedPubMedCentral

49.

Stine RR, Shapira SN, Lim HW, Ishibashi J, Harms M, Won KJ, Seale P (2016) EBF2 promotes the recruitment of beige adipocytes in white adipose tissue. Mol Metab 5(1):57–65. https://doi.org/10.1016/j.molmet.2015.11.001 CrossRefPubMed

50.

Deis JA, Guo H, Wu Y, Liu C, Bernlohr DA, Chen X (2019) Adipose Lipocalin 2 overexpression protects against age-related decline in thermogenic function of adipose tissue and metabolic deterioration. Mol Metab. https://doi.org/10.1016/j.molmet.2019.03.007 CrossRef

51.

Brennan PJ, Brigl M, Brenner MB (2013) Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions. Nat Rev Immunol 13(2):101–117. https://doi.org/10.1038/nri3369 CrossRefPubMed

52.

Huh JY, Park YJ, Ham M, Kim JB (2014) Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity. Mol Cells 37(5):365–371. https://doi.org/10.14348/molcells.2014.0074 CrossRefPubMedPubMedCentral

53.

Carter JM, Hoskin TL, Pena MA, Brahmbhatt R, Winham SJ, Frost MH, Stallings-Mann M, Radisky DC, Knutson KL, Visscher DW, Degnim AC (2018) Macrophagic “crown-like structures” are associated with an increased risk of breast cancer in benign breast disease. Cancer Prev Res (Phila) 11(2):113–119. https://doi.org/10.1158/1940-6207.Capr-17-0245 CrossRef

54.

Murano I, Barbatelli G, Parisani V, Latini C, Muzzonigro G, Castellucci M, Cinti S (2008) Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice. J Lipid Res 49(7):1562–1568. https://doi.org/10.1194/jlr.M800019-JLR200 CrossRefPubMed

55.

Altintas MM, Azad A, Nayer B, Contreras G, Zaias J, Faul C, Reiser J, Nayer A (2011) Mast cells, macrophages, and crown-like structures distinguish subcutaneous from visceral fat in mice. J Lipid Res 52(3):480–488. https://doi.org/10.1194/jlr.M011338 CrossRefPubMedPubMedCentral

56.

Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB, Benoist C, Shoelson S, Mathis D (2009) Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 15(8):930–939. https://doi.org/10.1038/nm.2002 CrossRefPubMedPubMedCentral

57.

Lin J, Cai Q, Liang B, Wu L, Zhuang Y, He Y, Lin W (2019) Berberine, a traditional Chinese medicine, reduces inflammation in adipose tissue, polarizes M2 macrophages, and increases energy expenditure in mice fed a high-fat diet. Med Sci Monit 25:87–97. https://doi.org/10.12659/msm.911849 CrossRefPubMedPubMedCentral

58.

Rouault C, Pellegrinelli V, Schilch R, Cotillard A, Poitou C, Tordjman J, Sell H, Clement K, Lacasa D (2013) Roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial cell function and inflammation of human adipose tissue. Endocrinology 154(3):1069–1079. https://doi.org/10.1210/en.2012-1415 CrossRefPubMed

59.

Nawaz A, Tobe K (2019) M2-like macrophages serve as a niche for adipocyte progenitors in adipose tissue. J Diabetes Investig. https://doi.org/10.1111/jdi.13114 CrossRef

60.

Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M (2005) IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11(2):191–198. https://doi.org/10.1038/nm1185 CrossRefPubMed

61.

Shin KC, Hwang I, Choe SS, Park J, Ji Y, Kim JI, Lee GY, Choi SH, Ching J, Kovalik JP, Kim JB (2017) Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation. Nat Commun 8(1):1087. https://doi.org/10.1038/s41467-017-01232-w CrossRefPubMedPubMedCentral

62.

Bertola A, Ciucci T, Rousseau D, Bourlier V, Duffaut C, Bonnafous S, Blin-Wakkach C, Anty R, Iannelli A, Gugenheim J, Tran A, Bouloumie A, Gual P, Wakkach A (2012) Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients. Diabetes 61(9):2238–2247. https://doi.org/10.2337/db11-1274 CrossRefPubMedPubMedCentral

63.

Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM (2011) Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 332(6026):243–247. https://doi.org/10.1126/science.1201475 CrossRefPubMedPubMedCentral

64.

Wensveen FM, Valentic S, Sestan M, Turk Wensveen T, Polic B (2015) The “big bang” in obese fat: events initiating obesity-induced adipose tissue inflammation. Eur J Immunol 45(9):2446–2456. https://doi.org/10.1002/eji.201545502 CrossRefPubMed

65.

Wang Q, Xie Z, Zhang W, Zhou J, Wu Y, Zhang M, Zhu H, Zou MH (2014) Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance. Diabetes 63(12):4172–4185. https://doi.org/10.2337/db14-0026 CrossRefPubMedPubMedCentral

66.

Chng MH, Alonso MN, Barnes SE, Nguyen KD, Engleman EG (2015) Adaptive immunity and antigen-specific activation in obesity-associated insulin resistance. Mediat Inflamm 2015:593075. https://doi.org/10.1155/2015/593075 CrossRef

67.

Winer S, Chan Y, Paltser G, Truong D, Tsui H, Bahrami J, Dorfman R, Wang Y, Zielenski J, Mastronardi F, Maezawa Y, Drucker DJ, Engleman E, Winer D, Dosch HM (2009) Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med 15(8):921–929. https://doi.org/10.1038/nm.2001 CrossRefPubMedPubMedCentral

68.

Shi MA, Shi GP (2012) Different roles of mast cells in obesity and diabetes: lessons from experimental animals and humans. Front Immunol 3:7. https://doi.org/10.3389/fimmu.2012.00007 CrossRefPubMedPubMedCentral

69.

Hirai S, Ohyane C, Kim YI, Lin S, Goto T, Takahashi N, Kim CS, Kang J, Yu R, Kawada T (2014) Involvement of mast cells in adipose tissue fibrosis. Am J Phys Endocrinol Metab 306(3):E247–E255. https://doi.org/10.1152/ajpendo.00056.2013 CrossRef

70.

Garcia-Rubio J, Leon J, Redruello-Romero A, Pavon E, Cozar A, Tamayo F, Caba-Molina M, Salmeron J, Carazo A (2018) Cytometric analysis of adipose tissue reveals increments of adipocyte progenitor cells after weight loss induced by bariatric surgery. Sci Rep 8(1):15203. https://doi.org/10.1038/s41598-018-33488-7 CrossRefPubMedPubMedCentral

71.

Zhou Y, Yu X, Chen H, Sjoberg S, Roux J, Zhang L, Ivoulsou AH, Bensaid F, Liu CL, Liu J, Tordjman J, Clement K, Lee CH, Hotamisligil GS, Libby P, Shi GP (2015) Leptin deficiency shifts mast cells toward anti-inflammatory actions and protects mice from obesity and diabetes by polarizing M2 macrophages. Cell Metab 22(6):1045–1058. https://doi.org/10.1016/j.cmet.2015.09.013 CrossRefPubMedPubMedCentral

72.

Zelechowska P, Wiktorska M, Rozalska S, Stasikowska-Kanicka O, Wagrowska-Danilewicz M, Agier J, Brzezinska-Blaszczyk E (2018) Leptin receptor is expressed by tissue mast cells. Immunol Res 66(5):557–566. https://doi.org/10.1007/s12026-018-9029-0 CrossRefPubMedPubMedCentral

73.

Tanaka A, Nomura Y, Matsuda A, Ohmori K, Matsuda H (2011) Mast cells function as an alternative modulator of adipogenesis through 15-deoxy-delta-12, 14-prostaglandin J2. Am J Physiol Cell Physiol 301(6):C1360–C1367. https://doi.org/10.1152/ajpcell.00514.2010 CrossRefPubMed

74.

Kumar D, Pandya SK, Varshney S, Shankar K, Rajan S, Srivastava A, Gupta A, Gupta S, Vishwakarma AL, Misra A, Gaikwad AN (2018) Temporal immmunometabolic profiling of adipose tissue in HFD-induced obesity: manifestations of mast cells in fibrosis and senescence. Int J Obes (Lond) 43:1281–1294. https://doi.org/10.1038/s41366-018-0228-5 CrossRef

75.

Ishijima Y, Ohmori S, Ohneda K (2013) Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice. FEBS Open Bio 4:18–24. https://doi.org/10.1016/j.fob.2013.11.004 CrossRefPubMedPubMedCentral

76.

Grimbaldeston MA, Chen CC, Piliponsky AM, Tsai M, Tam SY, Galli SJ (2005) Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo. Am J Pathol 167(3):835–848. https://doi.org/10.1016/s0002-9440(10)62055-x CrossRefPubMedPubMedCentral

77.

Michel A, Schuler A, Friedrich P, Doner F, Bopp T, Radsak M, Hoffmann M, Relle M, Distler U, Kuharev J, Tenzer S, Feyerabend TB, Rodewald HR, Schild H, Schmitt E, Becker M, Stassen M (2013) Mast cell-deficient Kit(W-sh) “Sash” mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells. J Immunol 190(11):5534–5544. https://doi.org/10.4049/jimmunol.1203355 CrossRefPubMed

78.

Gutierrez DA, Muralidhar S, Feyerabend TB, Herzig S, Rodewald HR (2015) Hematopoietic kit deficiency, rather than lack of mast cells, protects mice from obesity and insulin resistance. Cell Metab 21(5):678–691. https://doi.org/10.1016/j.cmet.2015.04.013 CrossRefPubMed

79.

Chmelar J, Chatzigeorgiou A, Chung KJ, Prucnal M, Voehringer D, Roers A, Chavakis T (2016) No role for mast cells in obesity-related metabolic dysregulation. Front Immunol 7:524. https://doi.org/10.3389/fimmu.2016.00524 CrossRefPubMedPubMedCentral

80.

Folkesson M, Vorkapic E, Gulbins E, Japtok L, Kleuser B, Welander M, Lanne T, Wagsater D (2017) Inflammatory cells, ceramides, and expression of proteases in perivascular adipose tissue adjacent to human abdominal aortic aneurysms. J Vasc Surg 65(4):1171–1179.e1171. https://doi.org/10.1016/j.jvs.2015.12.056 CrossRefPubMed

81.

Finlin BS, Zhu B, Confides AL, Westgate PM, Harfmann BD, Dupont-Versteegden EE, Kern PA (2017) Mast cells promote seasonal white adipose beiging in humans. Diabetes 66(5):1237–1246. https://doi.org/10.2337/db16-1057 CrossRefPubMedPubMedCentral

82.

Baron DM, Clerte M, Brouckaert P, Raher MJ, Flynn AW, Zhang H, Carter EA, Picard MH, Bloch KD, Buys ES, Scherrer-Crosbie M (2012) In vivo noninvasive characterization of brown adipose tissue blood flow by contrast ultrasound in mice. Circ Cardiovasc Imaging 5(5):652–659. https://doi.org/10.1161/circimaging.112.975607 CrossRefPubMedPubMedCentral

83.

Karlstedt K, Ahman MJ, Anichtchik OV, Soinila S, Panula P (2003) Expression of the H3 receptor in the developing CNS and brown fat suggests novel roles for histamine. Mol Cell Neurosci 24(3):614–622CrossRef

84.

Zhang X, Wang X, Yin H, Zhang L, Feng A, Zhang QX, Lin Y, Bao B, Hernandez LL, Shi GP, Liu J (2019) Functional inactivation of mast cells enhances subcutaneous adipose tissue browning in mice. Cell Rep 28(3):792–803.e794. https://doi.org/10.1016/j.celrep.2019.06.044 CrossRefPubMedPubMedCentral

85.

Lim J, Iyer A, Liu L, Suen JY, Lohman RJ, Seow V, Yau MK, Brown L, Fairlie DP (2013) Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism. FASEB J 27(12):4757–4767. https://doi.org/10.1096/fj.13-232702 CrossRefPubMed

86.

Paupert J, Espinosa E (2018) Rapid and efficient production of human functional mast cells through a three-dimensional culture of adipose tissue-derived stromal vascular cells. 201(12):3815–3821. https://doi.org/10.4049/jimmunol.1701751 CrossRef

87.

El-Haggar SM, Farrag WF, Kotkata FA (2015) Effect of ketotifen in obese patients with type 2 diabetes mellitus. J Diabetes Complicat 29(3):427–432. https://doi.org/10.1016/j.jdiacomp.2015.01.013 CrossRefPubMed

88.

Gurung P, Moussa K, Adams-Huet B, Devaraj S, Jialal I (2019) Increased mast cell abundance in adipose tissue of metabolic syndrome: relevance to the proinflammatory state and increased adipose tissue fibrosis. Am J Phys Endocrinol Metab 316(3):E504–e509. https://doi.org/10.1152/ajpendo.00462.2018 CrossRef

Title: Crosstalk Between Mast Cells and Adipocytes in Physiologic and Pathologic Conditions
Authors: Daniel Elieh Ali Komi
Farzaneh Shafaghat
Mark Christian
Publication date: 01-06-2020
Publisher: Springer US
Keywords: Obesity
Obesity
Published in: Clinical Reviews in Allergy & Immunology / Issue 3/2020
Print ISSN: 1080-0549
Electronic ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-020-08785-7

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Crosstalk Between Mast Cells and Adipocytes in Physiologic and Pathologic Conditions

Abstract

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2020

Role of Mast Cells in Shaping the Tumor Microenvironment

A Review of the Contribution of Mast Cells in Wound Healing: Involved Molecular and Cellular Mechanisms

Bee Venom Immunotherapy: Current Status and Future Directions

The Role of Mast Cells in IgE-Independent Lung Diseases

The Relationship Between Hypermobile Ehlers-Danlos Syndrome (hEDS), Postural Orthostatic Tachycardia Syndrome (POTS), and Mast Cell Activation Syndrome (MCAS)

Mast Cell Biology at Molecular Level: a Comprehensive Review

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page