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Clinical Reviews in Allergy & Immunology

Published in:

01-02-2010

Genetic Insights into Congenital Neutropenia

Authors: Christoph Klein, Karl Welte

Published in: Clinical Reviews in Allergy & Immunology | Issue 1/2010

Abstract

Congenital neutropenia syndromes comprise a heterogeneous group of disorders leading to increased susceptibility to bacterial infections. Recent work has elucidated the molecular basis of several congenital neutropenia syndromes such as mutations in ELA2, HAX1, GF11, and WAS. In addition, a number of complex clinical syndromes associating congenital neutropenia have been recognized and elucidated on a genetic level, e.g. p14-deficiency or G6PC3-deficiency. The clinical and genetic findings of various neutropenia syndromes are being discussed.

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Title: Genetic Insights into Congenital Neutropenia
Authors: Christoph Klein
Karl Welte
Publication date: 01-02-2010
Publisher: Humana Press Inc
Published in: Clinical Reviews in Allergy & Immunology / Issue 1/2010
Print ISSN: 1080-0549
Electronic ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-009-8130-5

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