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Clinical Reviews in Allergy & Immunology

Published in:

01-02-2009

Crosstalk of Liver, Bile Ducts and the Gut

Author: Ulrich Beuers

Published in: Clinical Reviews in Allergy & Immunology | Issue 1/2009

Abstract

A complex interplay of liver, bile ducts, and the gut critically determines functioning of these organs in health and disease. Biochemical and physiological aspects of their interaction and the role of inflammatory cells, cytokines, bile acids, visceral hormones, neuropeptides and other messengers in the pathogenesis of model immune-mediated hepatobiliary disorders are discussed in the actual issue of Clinical Reviews in Allergy and Immunology. Potential molecular targets for future therapeutic approaches are also addressed.

Beuers U, Boyer JL (1994) Bile—a historical review of studies on its form and function. In: Kirsner JB (ed) Gastroenterology in the 20th century. Lea & Ferbiger, New York, pp 267–288

Hofmann AF (2007) Biliary secretion and excretion in health and disease: current concepts. Ann Hepatol 6(1):15–27PubMed

Jones S (2008) Mini-review: endocrine actions of fibroblast growth factor 19. Mol Pharmacol 5:42–48CrossRef

Tacke F, Luedde T, Trautwein C (2008) Inflammatory pathways in liver homeostasis and liver injury. Clin Rev Allergy Immunol doi:10.1007/s12016-008-8091-0

Alvaro D, Mancino MG, Glaser S et al (2007) Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver. Gastroenterology 132(1):415–431PubMedCrossRef

Marzioni M, Fava G, Alvaro D, Alpini G, Benedetti A (2008) Control of cholangiocyte adaptive responses by visceral hormones and neuropeptides. Clin Rev Allergy Immunol doi:10.1007/s12016-008-8090-1

Gershwin ME, Mackay IR (2008) The causes of primary biliary cirrhosis: convenient and inconvenient truths. Hepatology 47(2):737–745PubMedCrossRef

Selmi C, Cocchi CA, Zuin M, Gershwin ME (2008) The chemical pathway to primary biliary cirrhosis. Clin Rev Allergy Immunol doi:10.1007/s12016-008-8089-7

Bogdanos DP, Vergani D (2008) Bacteria and primary biliary cirrhosis. Clin Rev Allergy Immunol doi:10.1007/s12016-008-8087-9

10.

LaRusso NF, Shneider BL, Black D et al (2006) Primary sclerosing cholangitis: summary of a workshop. Hepatology 44(3):746–764PubMedCrossRef

11.

Adams DH, Eksteen B (2006) Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease. Nat Rev Immunol 6(3):244–251PubMedCrossRef

12.

Terjung B, Spengler U (2008) Atypical p-ANCA in PSC and AIH: A hint towards a “leaky gut”? Clin Rev Allergy Immunol doi:10.1007/s12016-008-8088-8

13.

Cullen SN, Rust C, Fleming K, Edwards C, Beuers U, Chapman R (2008) High dose ursodeoxycholic acid for the treatment of primary sclerosig cholangitis is safe and effective. J Hepatol 48:792–800PubMedCrossRef

14.

Beuers U, Kullak-Ublick GA, Pusl T, Rauws ER, Rust C (2008) Medical treatment of primary sclerosing cholangitis: a role for novel bile acids and other (post-)transcriptional modulators? Clin Rev Allergy Immunol doi:10.1007/s12016-008-8085-y

15.

Volta U (2008) Pathogenesis and clinical significance of liver injury in celiac disease. Clin Rev Allergy Immunol doi:10.1007/s12016-008-8086-x

16.

Zollner G, Marschall HU, Wagner M, Trauner M (2006) Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations. Mol Pharmacol 3(3):231–251CrossRef

17.

Paumgartner G, Pusl T (2008) Medical treatment of cholestatic liver disease. Clin Liver Dis 12(1):53–80PubMedCrossRef

18.

Zhou ZH, Tzioufas AG, Notkins AL (2007) Properties and function of polyreactive antibodies and polyreactive antigen-binding B cells. J Autoimmun 29:219–228PubMedCrossRef

19.

Peng Y, Martin DA, Kenkel J, Zhang K, Ogden CA, Elkon KB (2007) Innate and adaptive immune response to apoptotic cells. J Autoimmun 29:303–309PubMedCrossRef

20.

Cohen IR (2007) Biomarkers, self-antigens and the immunological homunculus. J Autoimmun 29:246–249PubMedCrossRef

21.

Tsonis IA, Avrameas S, Moutsopoulos HM (2007) Autoimmunity and pathophysiology. J Autoimmun 29:203–205PubMedCrossRef

22.

Lang KS, Burow A, Kurrer M, Lang PA, Recher M (2007) The role of the innate immune response in autoimmune disease. J Autoimmun 29:206–212PubMedCrossRef

23.

Milner J, Ward J, Keane-Myers A, Min B, Paul WE (2007) Repertoire-dependent immunopathology. J Autoimmun 29:257–261PubMedCrossRef

24.

Rowley B, Tang L, Shinton S, Hayakawa K, Hardy RR (2007) Autoreactive B-1 B cells: constraints on natural autoantibody B cell antigen receptors. J Autoimmun 29:236–245PubMedCrossRef

25.

Lan RY, Mackay IR, Gershwin ME (2007) Regulatory T cells in the prevention of mucosal inflammatory disease: patrolling the border. J Autoimmun 29:272–280PubMedCrossRef

26.

Avrameas S, Ternynck T, Tsonis IA, Lymberi P (2007) Naturally occurring B-cell autoreactivity: a critical overview. J Autoimmun 29:213–218PubMedCrossRef

Title: Crosstalk of Liver, Bile Ducts and the Gut
Author: Ulrich Beuers
Publication date: 01-02-2009
Publisher: Humana Press Inc
Published in: Clinical Reviews in Allergy & Immunology / Issue 1/2009
Print ISSN: 1080-0549
Electronic ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-008-8084-z

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Other articles of this Issue 1/2009

Inflammatory Pathways in Liver Homeostasis and Liver Injury

Atypical p-ANCA in PSC and AIH: A Hint Toward a “leaky gut”?

Bacteria and Primary Biliary Cirrhosis

Medical Treatment of Primary Sclerosing Cholangitis: A Role for Novel Bile Acids and other (post-)Transcriptional Modulators?

Control of Cholangiocyte Adaptive Responses by Visceral Hormones and Neuropeptides

Pathogenesis and Clinical Significance of Liver Injury in Celiac Disease

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Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

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