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Clinical Reviews in Allergy & Immunology
Published in: Clinical Reviews in Allergy & Immunology 1/2009

01-02-2009

Control of Cholangiocyte Adaptive Responses by Visceral Hormones and Neuropeptides

Authors: Marco Marzioni, Giammarco Fava, Domenico Alvaro, Gianfranco Alpini, Antonio Benedetti

Published in: Clinical Reviews in Allergy & Immunology | Issue 1/2009

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Abstract

Cholangiocytes, the epithelial cells lining the biliary tree, are the target cells in several liver diseases, termed cholangiopathies. Cholangiopathies are a challenge for clinicians and an enigma for scientists, as the pathogenetic mechanisms by which they develop, and the therapeutic tools for these diseases are still undefined. Several studies demonstrate that many visceral hormones, neuropeptides, and neurotransmitters modulate the adaptive changes of cholangiocytes to chronic cholestatic injury. The aim of this review is to present the recent findings that contributed to clarify the role of visceral hormones and neuropeptides in the regulation of the pathophysiology of cholestasis. These studies helped to shed light on some aspects of cholangiocyte pathophysiology, revealing novel perspectives for the clinical managements of cholangiopathies.
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Metadata
Title
Control of Cholangiocyte Adaptive Responses by Visceral Hormones and Neuropeptides
Authors
Marco Marzioni
Giammarco Fava
Domenico Alvaro
Gianfranco Alpini
Antonio Benedetti
Publication date
01-02-2009
Publisher
Humana Press Inc
Published in
Clinical Reviews in Allergy & Immunology / Issue 1/2009
Print ISSN: 1080-0549
Electronic ISSN: 1559-0267
DOI
https://doi.org/10.1007/s12016-008-8090-1

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