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Published in: Current Treatment Options in Gastroenterology 3/2017

01-09-2017 | Endoscopy (P Siersema, Section Editor)

Endoscopic Surveillance in Long-standing Colitis

Authors: Brigid S. Boland, MD, Amandeep Shergill, MD, MS, Tonya Kaltenbach, MD, MAS

Published in: Current Treatment Options in Gastroenterology | Issue 3/2017

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Opinion statement

There is a relative increase in the risk of colon cancer in patients with inflammatory bowel disease (IBD) affecting the colon, and endoscopic surveillance is advocated to mitigate this risk. The current standard practice is to survey this high-risk patient population using colonoscopy. Chromoendoscopy with targeted biopsies has emerged as the colonoscopy modality recommended by the major societies to optimize dysplasia detection. Studies over the past year support the improved yield from targeted as compared to random biopsies and improved dysplasia detection from chromoendoscopy as compared to white light endoscopy. Ongoing efforts should focus on the implementation of chromoendoscopy as the primary modality for colorectal cancer surveillance in IBD. Our review will describe current status and provide an update on the recent literature on surveillance colonoscopy in patients with IBD.
Literature
1.
go back to reference Jess T, Gamborg M, Matzen P, Munkholm P, Sorensen TI. Increased risk of intestinal cancer in Crohn’s disease: a meta-analysis of population-based cohort studies. Am J Gastroenterol. 2005;100(12):2724–9.CrossRefPubMed Jess T, Gamborg M, Matzen P, Munkholm P, Sorensen TI. Increased risk of intestinal cancer in Crohn’s disease: a meta-analysis of population-based cohort studies. Am J Gastroenterol. 2005;100(12):2724–9.CrossRefPubMed
2.
go back to reference Jess T, Rungoe C, Peyrin-Biroulet L. Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies. Clin Gastroenterol Hepatol. 2012;10(6):639–45.CrossRefPubMed Jess T, Rungoe C, Peyrin-Biroulet L. Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies. Clin Gastroenterol Hepatol. 2012;10(6):639–45.CrossRefPubMed
3.
go back to reference Beaugerie L, Itzkowitz SH. Cancers complicating inflammatory bowel disease. N Engl J Med. 2015;372(15):1441–52.CrossRefPubMed Beaugerie L, Itzkowitz SH. Cancers complicating inflammatory bowel disease. N Engl J Med. 2015;372(15):1441–52.CrossRefPubMed
4.
go back to reference Ekbom A, Helmick C, Zack M, Adami HO. Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med. 1990;323(18):1228–33.CrossRefPubMed Ekbom A, Helmick C, Zack M, Adami HO. Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med. 1990;323(18):1228–33.CrossRefPubMed
5.
go back to reference Lutgens MW, van Oijen MG, van der Heijden GJ, Vleggaar FP, Siersema PD, Oldenburg B. Declining risk of colorectal cancer in inflammatory bowel disease: an updated meta-analysis of population-based cohort studies. Inflamm Bowel Dis. 2013;19(4):789–99.CrossRefPubMed Lutgens MW, van Oijen MG, van der Heijden GJ, Vleggaar FP, Siersema PD, Oldenburg B. Declining risk of colorectal cancer in inflammatory bowel disease: an updated meta-analysis of population-based cohort studies. Inflamm Bowel Dis. 2013;19(4):789–99.CrossRefPubMed
6.
go back to reference Farraye FA, Odze RD, Eaden J, et al. AGA medical position statement on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease. Gastroenterology. 2010;138(2):738–45.CrossRefPubMed Farraye FA, Odze RD, Eaden J, et al. AGA medical position statement on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease. Gastroenterology. 2010;138(2):738–45.CrossRefPubMed
7.
go back to reference American Society for Gastrointestinal Endoscopy Standards of Practice C, Shergill AK, Lightdale JR, et al. The role of endoscopy in inflammatory bowel disease. Gastrointest Endosc. 2015;81(5):1101–21. e1101–1113 American Society for Gastrointestinal Endoscopy Standards of Practice C, Shergill AK, Lightdale JR, et al. The role of endoscopy in inflammatory bowel disease. Gastrointest Endosc. 2015;81(5):1101–21. e1101–1113
8.
go back to reference Annese V, Daperno M, Rutter MD, et al. European evidence based consensus for endoscopy in inflammatory bowel disease. J Crohns Colitis. 2013;7(12):982–1018.CrossRefPubMed Annese V, Daperno M, Rutter MD, et al. European evidence based consensus for endoscopy in inflammatory bowel disease. J Crohns Colitis. 2013;7(12):982–1018.CrossRefPubMed
9.
go back to reference Rubin CE, Haggitt RC, Burmer GC, et al. DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis. Gastroenterology. 1992;103(5):1611–20.CrossRefPubMed Rubin CE, Haggitt RC, Burmer GC, et al. DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis. Gastroenterology. 1992;103(5):1611–20.CrossRefPubMed
10.
go back to reference Chiorean MV, Helper DJ, Saxena R, et al. Targeted biopsies using chromoendsocopy can replace random biopsies in pateints with IBD at high risk for colorectal neoplasia. Gastroenterol. 2012;142(supp1):S-339.CrossRef Chiorean MV, Helper DJ, Saxena R, et al. Targeted biopsies using chromoendsocopy can replace random biopsies in pateints with IBD at high risk for colorectal neoplasia. Gastroenterol. 2012;142(supp1):S-339.CrossRef
11.
go back to reference Gunther U, Kusch D, Heller F, et al. Surveillance colonoscopy in patients with inflammatory bowel disease: comparison of random biopsy vs. targeted biopsy protocols. Int J Color Dis. 2011;26(5):667–72.CrossRef Gunther U, Kusch D, Heller F, et al. Surveillance colonoscopy in patients with inflammatory bowel disease: comparison of random biopsy vs. targeted biopsy protocols. Int J Color Dis. 2011;26(5):667–72.CrossRef
12.
go back to reference Hlavaty T, Huorka M, Koller T, et al. Colorectal cancer screening in patients with ulcerative and Crohn’s colitis with use of colonoscopy, chromoendoscopy and confocal endomicroscopy. Eur J Gastroenterol Hepatol. 2011;23(8):680–9.CrossRefPubMed Hlavaty T, Huorka M, Koller T, et al. Colorectal cancer screening in patients with ulcerative and Crohn’s colitis with use of colonoscopy, chromoendoscopy and confocal endomicroscopy. Eur J Gastroenterol Hepatol. 2011;23(8):680–9.CrossRefPubMed
13.
go back to reference Kiesslich R, Fritsch J, Holtmann M, et al. Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis. Gastroenterology. 2003;124(4):880–8.CrossRefPubMed Kiesslich R, Fritsch J, Holtmann M, et al. Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis. Gastroenterology. 2003;124(4):880–8.CrossRefPubMed
14.
go back to reference • Kiesslich R, Goetz M, Lammersdorf K, et al. Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis. Gastroenterology. 2007;132(3):874–82. Randomized clinical trial of chromoendoscopy with endomicroscopy versus conventional colonoscopy, showing an increase in dysplasia detection with chromoendoscopy with endomicroscopy.CrossRefPubMed • Kiesslich R, Goetz M, Lammersdorf K, et al. Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis. Gastroenterology. 2007;132(3):874–82. Randomized clinical trial of chromoendoscopy with endomicroscopy versus conventional colonoscopy, showing an increase in dysplasia detection with chromoendoscopy with endomicroscopy.CrossRefPubMed
15.
go back to reference Marion JF, Waye JD, Present DH, et al. Chromoendoscopy-targeted biopsies are superior to standard colonoscopic surveillance for detecting dysplasia in inflammatory bowel disease patients: a prospective endoscopic trial. Am J Gastroenterol. 2008;103(9):2342–9.CrossRefPubMed Marion JF, Waye JD, Present DH, et al. Chromoendoscopy-targeted biopsies are superior to standard colonoscopic surveillance for detecting dysplasia in inflammatory bowel disease patients: a prospective endoscopic trial. Am J Gastroenterol. 2008;103(9):2342–9.CrossRefPubMed
16.
go back to reference Matsumoto T, Nakamura S, Jo Y, Yao T, Iida M. Chromoscopy might improve diagnostic accuracy in cancer surveillance for ulcerative colitis. Am J Gastroenterol. 2003;98(8):1827–33.CrossRefPubMed Matsumoto T, Nakamura S, Jo Y, Yao T, Iida M. Chromoscopy might improve diagnostic accuracy in cancer surveillance for ulcerative colitis. Am J Gastroenterol. 2003;98(8):1827–33.CrossRefPubMed
17.
go back to reference Rutter MD, Saunders BP, Schofield G, Forbes A, Price AB, Talbot IC. Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative colitis. Gut. 2004;53(2):256–60.CrossRefPubMedPubMedCentral Rutter MD, Saunders BP, Schofield G, Forbes A, Price AB, Talbot IC. Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative colitis. Gut. 2004;53(2):256–60.CrossRefPubMedPubMedCentral
18.
go back to reference Picco MF, Pasha S, Leighton JA, et al. Procedure time and the determination of polypoid abnormalities with experience: implementation of a chromoendoscopy program for surveillance colonoscopy for ulcerative colitis. Inflamm Bowel Dis. 2013;19(9):1913–20.PubMed Picco MF, Pasha S, Leighton JA, et al. Procedure time and the determination of polypoid abnormalities with experience: implementation of a chromoendoscopy program for surveillance colonoscopy for ulcerative colitis. Inflamm Bowel Dis. 2013;19(9):1913–20.PubMed
19.
go back to reference Leong RW, Ooi M, Corte C, et al. Full-spectrum endoscopy improves surveillance for dysplasia in patients with inflammatory bowel diseases. Gastroenterology. 2017. Leong RW, Ooi M, Corte C, et al. Full-spectrum endoscopy improves surveillance for dysplasia in patients with inflammatory bowel diseases. Gastroenterology. 2017.
20.
go back to reference • Carballal S, Maisterra S, Lopez-Serrano A, et al. Real-life chromoendoscopy for neoplasia detection and characterisation in long-standing IBD. Gut. 2016. Prospective clinical trial of segmental white light endoscopy followed by chromoendoscopy showing an increase yield in dysplasia with chromoendoscopy. • Carballal S, Maisterra S, Lopez-Serrano A, et al. Real-life chromoendoscopy for neoplasia detection and characterisation in long-standing IBD. Gut. 2016. Prospective clinical trial of segmental white light endoscopy followed by chromoendoscopy showing an increase yield in dysplasia with chromoendoscopy.
21.
go back to reference Gasia MF, Ghosh S, Panaccione R, et al. Targeted biopsies identify larger proportions of patients with colonic neoplasia undergoing high-definition colonoscopy, dye chromoendoscopy, or electronic virtual chromoendoscopy. Clin Gastroenterol Hepatol. 2016;14(5):704–12. e704 Gasia MF, Ghosh S, Panaccione R, et al. Targeted biopsies identify larger proportions of patients with colonic neoplasia undergoing high-definition colonoscopy, dye chromoendoscopy, or electronic virtual chromoendoscopy. Clin Gastroenterol Hepatol. 2016;14(5):704–12. e704
22.
go back to reference Rubin D, Cleveland NK, Rodriguez DM. Outcomes of colitis-associated dysplasia after referral from the community to a tertiary care center. Gastrointest Endosc. 2016;83(5S):AB439.CrossRef Rubin D, Cleveland NK, Rodriguez DM. Outcomes of colitis-associated dysplasia after referral from the community to a tertiary care center. Gastrointest Endosc. 2016;83(5S):AB439.CrossRef
23.
go back to reference Marion JF, Waye JD, Israel Y, et al. Chromoendoscopy is more effective than standard colonoscopy in detecting dysplasia during long-term surveillance of patients with colitis. Clin Gastroenterol Hepatol. 2016;14(5):713–9.CrossRefPubMed Marion JF, Waye JD, Israel Y, et al. Chromoendoscopy is more effective than standard colonoscopy in detecting dysplasia during long-term surveillance of patients with colitis. Clin Gastroenterol Hepatol. 2016;14(5):713–9.CrossRefPubMed
24.
go back to reference Deepak P, Hanson GJ, Fletcher JG, et al. Incremental diagnostic yield of chromoendoscopy and outcomes in inflammatory bowel disease patients with a history of colorectal dysplasia on white-light endoscopy. Gastrointest Endosc. 2016;83(5):1005–12.CrossRefPubMed Deepak P, Hanson GJ, Fletcher JG, et al. Incremental diagnostic yield of chromoendoscopy and outcomes in inflammatory bowel disease patients with a history of colorectal dysplasia on white-light endoscopy. Gastrointest Endosc. 2016;83(5):1005–12.CrossRefPubMed
25.
go back to reference • Choi CH, Ignjatovic-Wilson A, Askari A, et al. Low-grade dysplasia in ulcerative colitis: risk factors for developing high-grade dysplasia or colorectal cancer. Am J Gastroenterol. 2015;110(10):1461–1471. quiz 1472. A retrospective study identified risk factors for progression to high grade dysplasia: lesions that were endoscopically invisible, lesions ≥1 cm, and prior biopsies that were indefinite for dysplasia. • Choi CH, Ignjatovic-Wilson A, Askari A, et al. Low-grade dysplasia in ulcerative colitis: risk factors for developing high-grade dysplasia or colorectal cancer. Am J Gastroenterol. 2015;110(10):1461–1471. quiz 1472. A retrospective study identified risk factors for progression to high grade dysplasia: lesions that were endoscopically invisible, lesions ≥1 cm, and prior biopsies that were indefinite for dysplasia.
26.
go back to reference Iacucci M, Gasia MF, Olusey A, et al. Final results of a randomised study comparing high-definition colonoscopy alone wiht high-definition dye spraying and electronic virtual chromoendoscopy using iSCAN for detection of colonic neoplastic lesions during IBD surveillance colonoscopy. ECCO Congress. 2016. Iacucci M, Gasia MF, Olusey A, et al. Final results of a randomised study comparing high-definition colonoscopy alone wiht high-definition dye spraying and electronic virtual chromoendoscopy using iSCAN for detection of colonic neoplastic lesions during IBD surveillance colonoscopy. ECCO Congress. 2016.
27.
go back to reference Park SJ, Kim H.S.; Yang, D.; et al. High definition chromoendoscopy with water-jet versus high definition white light endoscopy in the detection of dysplasia in long standing ulcerative colitis: a multicenter prospective randomized controlled study. International Meeting on Intestinal Diseases in Conjunction with the Annual Congress of the Korean Association for the Study of Intestinal Diseases. 2016(FP2-1). Park SJ, Kim H.S.; Yang, D.; et al. High definition chromoendoscopy with water-jet versus high definition white light endoscopy in the detection of dysplasia in long standing ulcerative colitis: a multicenter prospective randomized controlled study. International Meeting on Intestinal Diseases in Conjunction with the Annual Congress of the Korean Association for the Study of Intestinal Diseases. 2016(FP2-1).
28.
go back to reference Mohammed N, Kant P, Abid F, et al. High definition white light endoscopy (HDWLE) versus high definition with chromoendoscopy (HDCE) in the detection of dysplasia in long standing ulcerative colitis: a randomized controlled trial. Gastrointest Endosc. 2015;81(5S):A446. Mohammed N, Kant P, Abid F, et al. High definition white light endoscopy (HDWLE) versus high definition with chromoendoscopy (HDCE) in the detection of dysplasia in long standing ulcerative colitis: a randomized controlled trial. Gastrointest Endosc. 2015;81(5S):A446.
29.
go back to reference Iannone A, Ruospo M, Wong G, et al. Chromoendoscopy for surveillance in ulcerative colitis and Crohn’s disease: a systematic review of randomized trials. Clin Gastroenterol Hepatol 2016. Iannone A, Ruospo M, Wong G, et al. Chromoendoscopy for surveillance in ulcerative colitis and Crohn’s disease: a systematic review of randomized trials. Clin Gastroenterol Hepatol 2016.
30.
go back to reference Dekker E, van den Broek FJ, Reitsma JB, et al. Narrow-band imaging compared with conventional colonoscopy for the detection of dysplasia in patients with longstanding ulcerative colitis. Endoscopy. 2007;39(3):216–21.CrossRefPubMed Dekker E, van den Broek FJ, Reitsma JB, et al. Narrow-band imaging compared with conventional colonoscopy for the detection of dysplasia in patients with longstanding ulcerative colitis. Endoscopy. 2007;39(3):216–21.CrossRefPubMed
31.
go back to reference Ignjatovic A, East JE, Subramanian V, et al. Narrow band imaging for detection of dysplasia in colitis: a randomized controlled trial. Am J Gastroenterol. 2012;107(6):885–90.CrossRefPubMed Ignjatovic A, East JE, Subramanian V, et al. Narrow band imaging for detection of dysplasia in colitis: a randomized controlled trial. Am J Gastroenterol. 2012;107(6):885–90.CrossRefPubMed
32.
go back to reference van den Broek FJ, Fockens P, van Eeden S, et al. Narrow-band imaging versus high-definition endoscopy for the diagnosis of neoplasia in ulcerative colitis. Endoscopy. 2011;43(2):108–15.CrossRefPubMed van den Broek FJ, Fockens P, van Eeden S, et al. Narrow-band imaging versus high-definition endoscopy for the diagnosis of neoplasia in ulcerative colitis. Endoscopy. 2011;43(2):108–15.CrossRefPubMed
33.
go back to reference Ten Hove JR, Mooiweer E, van der Meulen de Jong AE, et al. Clinical implications of low grade dysplasia found during inflammatory bowel disease surveillance: a retrospective study comparing chromoendoscopy and white-light endoscopy. Endoscopy 2016. Ten Hove JR, Mooiweer E, van der Meulen de Jong AE, et al. Clinical implications of low grade dysplasia found during inflammatory bowel disease surveillance: a retrospective study comparing chromoendoscopy and white-light endoscopy. Endoscopy 2016.
34.
go back to reference Thomas T, Abrams KA, Robinson RJ, Mayberry JF. Meta-analysis: cancer risk of low-grade dysplasia in chronic ulcerative colitis. Aliment Pharmacol Ther. 2007;25(6):657–68.CrossRefPubMed Thomas T, Abrams KA, Robinson RJ, Mayberry JF. Meta-analysis: cancer risk of low-grade dysplasia in chronic ulcerative colitis. Aliment Pharmacol Ther. 2007;25(6):657–68.CrossRefPubMed
35.
go back to reference • Rutter MD, Saunders BP, Wilkinson KH, Kamm MA, Williams CB, Forbes A. Most dysplasia in ulcerative colitis is visible at colonoscopy. Gastrointest Endosc. 2004;60(3):334–9. Prospective cohort study showing that most colonic lesions can be identified with chromoendoscopy.CrossRefPubMed • Rutter MD, Saunders BP, Wilkinson KH, Kamm MA, Williams CB, Forbes A. Most dysplasia in ulcerative colitis is visible at colonoscopy. Gastrointest Endosc. 2004;60(3):334–9. Prospective cohort study showing that most colonic lesions can be identified with chromoendoscopy.CrossRefPubMed
36.
go back to reference • Laine L, Kaltenbach T, Barkun A, et al. SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease. Gastrointest Endosc. 2015;81(3):489–501 e426. SCENIC international consensus statement guiding surveillance and management of dysplasia in the setting of inflammatory bowel disease.CrossRefPubMed • Laine L, Kaltenbach T, Barkun A, et al. SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease. Gastrointest Endosc. 2015;81(3):489–501 e426. SCENIC international consensus statement guiding surveillance and management of dysplasia in the setting of inflammatory bowel disease.CrossRefPubMed
37.
go back to reference Rutter MD. Surveillance programmes for neoplasia in colitis. J Gastroenterol. 2011;46(Suppl 1):1–5.CrossRefPubMed Rutter MD. Surveillance programmes for neoplasia in colitis. J Gastroenterol. 2011;46(Suppl 1):1–5.CrossRefPubMed
38.
go back to reference Bopanna S, Kedia S, Ahuja V. A low-cost method for chromoendoscopy for surveillance in ulcerative colitis. Indian J Gastroenterol. 2016;35(6):482–5.CrossRefPubMed Bopanna S, Kedia S, Ahuja V. A low-cost method for chromoendoscopy for surveillance in ulcerative colitis. Indian J Gastroenterol. 2016;35(6):482–5.CrossRefPubMed
39.
go back to reference • Watanabe T, Ajioka Y, Mitsuyama K, et al. Comparison of targeted vs random biopsies for surveillance of ulcerative colitis-associated colorectal cancer. Gastroenterology. 2016;151(6):1122–30. Randomized controlled study of surveillance in ulcerative colitis showing that the neoplasia yield from targeted biopsies is greater than random biopsies.CrossRefPubMed • Watanabe T, Ajioka Y, Mitsuyama K, et al. Comparison of targeted vs random biopsies for surveillance of ulcerative colitis-associated colorectal cancer. Gastroenterology. 2016;151(6):1122–30. Randomized controlled study of surveillance in ulcerative colitis showing that the neoplasia yield from targeted biopsies is greater than random biopsies.CrossRefPubMed
40.
go back to reference Moussata D, Allez M, Cazals-Hatem D, et al. Are random biopsies still useful for the detection of neoplasia in patients with IBD undergoing surveillance colonoscopy with chromoendoscopy? Gut. 2017. Moussata D, Allez M, Cazals-Hatem D, et al. Are random biopsies still useful for the detection of neoplasia in patients with IBD undergoing surveillance colonoscopy with chromoendoscopy? Gut. 2017.
41.
go back to reference Sanduleanu S, Kaltenbach T, Barkun A, et al. A roadmap to the implementation of chromoendoscopy in inflammatory bowel disease colonoscopy surveillance practice. Gastrointest Endosc. 2016;83(1):213–22.CrossRefPubMed Sanduleanu S, Kaltenbach T, Barkun A, et al. A roadmap to the implementation of chromoendoscopy in inflammatory bowel disease colonoscopy surveillance practice. Gastrointest Endosc. 2016;83(1):213–22.CrossRefPubMed
42.
go back to reference Konijeti GG, Shrime MG, Ananthakrishnan AN, Chan AT. Cost-effectiveness analysis of chromoendoscopy for colorectal cancer surveillance in patients with ulcerative colitis. Gastrointest Endosc. 2014;79(3):455–65.CrossRefPubMed Konijeti GG, Shrime MG, Ananthakrishnan AN, Chan AT. Cost-effectiveness analysis of chromoendoscopy for colorectal cancer surveillance in patients with ulcerative colitis. Gastrointest Endosc. 2014;79(3):455–65.CrossRefPubMed
Metadata
Title
Endoscopic Surveillance in Long-standing Colitis
Authors
Brigid S. Boland, MD
Amandeep Shergill, MD, MS
Tonya Kaltenbach, MD, MAS
Publication date
01-09-2017
Publisher
Springer US
Published in
Current Treatment Options in Gastroenterology / Issue 3/2017
Print ISSN: 1092-8472
Electronic ISSN: 1534-309X
DOI
https://doi.org/10.1007/s11938-017-0141-3

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