Skip to main content
Top
Published in: Current Rheumatology Reports 9/2015

Open Access 01-09-2015 | Health Economics and Quality of Life (M Harrison, Section Editor)

A Review of Patient Preferences for Osteoporosis Drug Treatment

Authors: Mickaël Hiligsmann, Sandrine P. G. Bours, Annelies Boonen

Published in: Current Rheumatology Reports | Issue 9/2015

Login to get access

Abstract

Poor medication adherence is a major problem in chronic diseases such as osteoporosis that may partially be due to unaddressed patient values and preferences. Data on patient preferences could help clinicians to improve medication adherence and could also be useful in policy decisions and guideline development. This paper aims to identify literature reporting on the preferences of patients for osteoporosis drug medications. Several methods have been used to elicit patient preferences for medications and their characteristics including qualitative research, survey with ranking/rating exercises, discrete-choice experiments and clinical studies (crossover designs, open-label study). All these studies revealed that osteoporotic patients have preferences for medications and their attributes, in particular for less-frequent dosing regimens. Interestingly, variations in the preferences of patients were observed in most studies, suggesting the importance to take into account individual preference in decision-making to improve osteoporosis care.
Literature
1.
go back to reference Hernlund E, Svedbom A, Ivergard M, Compston J, Cooper C, Stenmark J, et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos. 2013;8(1-2):136.PubMedCentralCrossRefPubMed Hernlund E, Svedbom A, Ivergard M, Compston J, Cooper C, Stenmark J, et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos. 2013;8(1-2):136.PubMedCentralCrossRefPubMed
2.
go back to reference Reginster JY. Antifracture efficacy of currently available therapies for postmenopausal osteoporosis. Drugs. 2011;71(1):65–78.CrossRefPubMed Reginster JY. Antifracture efficacy of currently available therapies for postmenopausal osteoporosis. Drugs. 2011;71(1):65–78.CrossRefPubMed
3.
go back to reference Netelenbos JC, Geusens PP, Ypma G, Buijs SJ. Adherence and profile of non-persistence in patients treated for osteoporosis—a large-scale, long-term retrospective study in The Netherlands. Osteoporos Int. 2011;22(5):1537–46.PubMedCentralCrossRefPubMed Netelenbos JC, Geusens PP, Ypma G, Buijs SJ. Adherence and profile of non-persistence in patients treated for osteoporosis—a large-scale, long-term retrospective study in The Netherlands. Osteoporos Int. 2011;22(5):1537–46.PubMedCentralCrossRefPubMed
4.
go back to reference Hiligsmann M, McGowan B, Bennett K, Barry M, Reginster JY. The clinical and economic burden of poor adherence and persistence with osteoporosis medications in Ireland. Value Health. 2012;15(5):604–12.CrossRefPubMed Hiligsmann M, McGowan B, Bennett K, Barry M, Reginster JY. The clinical and economic burden of poor adherence and persistence with osteoporosis medications in Ireland. Value Health. 2012;15(5):604–12.CrossRefPubMed
5.
go back to reference Montori VM, Shah ND, Pencille LJ, Branda ME, Van Houten HK, Swiglo BA, et al. Use of a decision aid to improve treatment decisions in osteoporosis: the osteoporosis choice randomized trial. Am J Med. 2011;124(6):549–56.CrossRefPubMed Montori VM, Shah ND, Pencille LJ, Branda ME, Van Houten HK, Swiglo BA, et al. Use of a decision aid to improve treatment decisions in osteoporosis: the osteoporosis choice randomized trial. Am J Med. 2011;124(6):549–56.CrossRefPubMed
6.
go back to reference Brennan PF, Strombom I. Improving health care by understanding patient preferences: the role of computer technology. J Am Med Inform Assoc. 1998;5(3):257–62.PubMedCentralCrossRefPubMed Brennan PF, Strombom I. Improving health care by understanding patient preferences: the role of computer technology. J Am Med Inform Assoc. 1998;5(3):257–62.PubMedCentralCrossRefPubMed
7.••
go back to reference Kendler DL, Macarios D, Lillestol MJ, Moffett A, Satram-Hoang S, Huang J, et al. Influence of patient perceptions and preferences for osteoporosis medication on adherence behavior in the Denosumab Adherence Preference Satisfaction study. Menopause. 2014;21(1):25–32. Interesting article showing that better perceptions and preferences leads to improved medication adherence in osteoporosis.CrossRefPubMed Kendler DL, Macarios D, Lillestol MJ, Moffett A, Satram-Hoang S, Huang J, et al. Influence of patient perceptions and preferences for osteoporosis medication on adherence behavior in the Denosumab Adherence Preference Satisfaction study. Menopause. 2014;21(1):25–32. Interesting article showing that better perceptions and preferences leads to improved medication adherence in osteoporosis.CrossRefPubMed
8.
go back to reference Barrett-Connor E, Wade SW, Do TP, Satram-Hoang S, Stewart R, Gao G, et al. Treatment satisfaction and persistence among postmenopausal women on osteoporosis medications: 12-month results from POSSIBLE US. Osteoporos Int. 2012;23(2):733–41.CrossRefPubMed Barrett-Connor E, Wade SW, Do TP, Satram-Hoang S, Stewart R, Gao G, et al. Treatment satisfaction and persistence among postmenopausal women on osteoporosis medications: 12-month results from POSSIBLE US. Osteoporos Int. 2012;23(2):733–41.CrossRefPubMed
9.
go back to reference Bridges JF. Future challenges for the economic evaluation of healthcare: patient preferences, risk attitudes and beyond. PharmacoEconomics. 2005;23(4):317–21.CrossRefPubMed Bridges JF. Future challenges for the economic evaluation of healthcare: patient preferences, risk attitudes and beyond. PharmacoEconomics. 2005;23(4):317–21.CrossRefPubMed
10.
go back to reference Strull WM, Lo B, Charles G. Do patients want to participate in medical decision making? JAMA. 1984;252(21):2990–4.CrossRefPubMed Strull WM, Lo B, Charles G. Do patients want to participate in medical decision making? JAMA. 1984;252(21):2990–4.CrossRefPubMed
11.
go back to reference Joy SM, Little E, Maruthur NM, Purnell TS, Bridges JF. Patient preferences for the treatment of type 2 diabetes: a scoping review. PharmacoEconomics. 2013;31(10):877–92.CrossRefPubMed Joy SM, Little E, Maruthur NM, Purnell TS, Bridges JF. Patient preferences for the treatment of type 2 diabetes: a scoping review. PharmacoEconomics. 2013;31(10):877–92.CrossRefPubMed
12.
go back to reference Weiss TW, Gold DT, Silverman SL, McHorney CA. An evaluation of patient preferences for osteoporosis medication attributes: results from the PREFER-US study. Curr Med Res Opin. 2006;22(5):949–60.CrossRefPubMed Weiss TW, Gold DT, Silverman SL, McHorney CA. An evaluation of patient preferences for osteoporosis medication attributes: results from the PREFER-US study. Curr Med Res Opin. 2006;22(5):949–60.CrossRefPubMed
13.
go back to reference Duarte JW, Bolge SC, Sen SS. An evaluation of patients’ preferences for osteoporosis medications and their attributes: the PREFER-International study. Clin Ther. 2007;29(3):488–503.CrossRefPubMed Duarte JW, Bolge SC, Sen SS. An evaluation of patients’ preferences for osteoporosis medications and their attributes: the PREFER-International study. Clin Ther. 2007;29(3):488–503.CrossRefPubMed
14.•
go back to reference Hiligsmann M, van Durme C, Geusens P, Dellaert BG, Dirksen CD, van der Weijden T, et al. Nominal group technique to select attributes for discrete choice experiments: an example for drug treatment choice in osteoporosis. Patient Prefer Adherence. 2013;7:133–9. Using an innovative method, this article revealed most important anti-osteoporosis medication attributes.PubMedCentralCrossRefPubMed Hiligsmann M, van Durme C, Geusens P, Dellaert BG, Dirksen CD, van der Weijden T, et al. Nominal group technique to select attributes for discrete choice experiments: an example for drug treatment choice in osteoporosis. Patient Prefer Adherence. 2013;7:133–9. Using an innovative method, this article revealed most important anti-osteoporosis medication attributes.PubMedCentralCrossRefPubMed
15.•
go back to reference Silverman S, Calderon A, Kaw K, Childers TB, Stafford BA, Brynildsen W, et al. Patient weighting of osteoporosis medication attributes across racial and ethnic groups: a study of osteoporosis medication preferences using conjoint analysis. Osteoporos Int. 2013;24(7):2067–77. Interesting study assessing the preferences of patients for medication attributes across different subgroups.CrossRefPubMed Silverman S, Calderon A, Kaw K, Childers TB, Stafford BA, Brynildsen W, et al. Patient weighting of osteoporosis medication attributes across racial and ethnic groups: a study of osteoporosis medication preferences using conjoint analysis. Osteoporos Int. 2013;24(7):2067–77. Interesting study assessing the preferences of patients for medication attributes across different subgroups.CrossRefPubMed
16.
go back to reference Darba J, Restovic G, Kaskens L, Balbona MA, Carbonell A, Cavero P, et al. Patient preferences for osteoporosis in Spain: a discrete choice experiment. Osteoporos Int. 2011;22(6):1947–54.CrossRefPubMed Darba J, Restovic G, Kaskens L, Balbona MA, Carbonell A, Cavero P, et al. Patient preferences for osteoporosis in Spain: a discrete choice experiment. Osteoporos Int. 2011;22(6):1947–54.CrossRefPubMed
17.
go back to reference de Bekker-Grob EW, Essink-Bot ML, Meerding WJ, Pols HA, Koes BW, Steyerberg EW. Patients’ preferences for osteoporosis drug treatment: a discrete choice experiment. Osteoporos Int. 2008;19(7):1029–37.PubMedCentralCrossRefPubMed de Bekker-Grob EW, Essink-Bot ML, Meerding WJ, Pols HA, Koes BW, Steyerberg EW. Patients’ preferences for osteoporosis drug treatment: a discrete choice experiment. Osteoporos Int. 2008;19(7):1029–37.PubMedCentralCrossRefPubMed
19.••
go back to reference Hiligsmann M, Dellaert BG, Dirksen CD, van der Weijden T, Goemaere S, Reginster JY, et al. Patients’ preferences for osteoporosis drug treatment: a discrete-choice experiment. Arthritis Res Ther. 2014;16(1):R36. Interesting study that included preferences for recent modes of administration using a discrete-choice experiment and revealed the substantial heterogeneity in patients’ preferences.PubMedCentralCrossRefPubMed Hiligsmann M, Dellaert BG, Dirksen CD, van der Weijden T, Goemaere S, Reginster JY, et al. Patients’ preferences for osteoporosis drug treatment: a discrete-choice experiment. Arthritis Res Ther. 2014;16(1):R36. Interesting study that included preferences for recent modes of administration using a discrete-choice experiment and revealed the substantial heterogeneity in patients’ preferences.PubMedCentralCrossRefPubMed
21.•
go back to reference Laba TL. Using Discrete Choice Experiment to elicit patient preferences for osteoporosis drug treatments: where to from here? Arthritis Res Ther. 2014;16(2):106. Interesting editorial about the value of a preferences-based study in osteoporosis.PubMedCentralCrossRefPubMed Laba TL. Using Discrete Choice Experiment to elicit patient preferences for osteoporosis drug treatments: where to from here? Arthritis Res Ther. 2014;16(2):106. Interesting editorial about the value of a preferences-based study in osteoporosis.PubMedCentralCrossRefPubMed
22.
go back to reference Keen R, Jodar E, Iolascon G, Kruse HP, Varbanov A, Mann B, et al. European women’s preference for osteoporosis treatment: influence of clinical effectiveness and dosing frequency. Curr Med Res Opin. 2006;22(12):2375–81.CrossRefPubMed Keen R, Jodar E, Iolascon G, Kruse HP, Varbanov A, Mann B, et al. European women’s preference for osteoporosis treatment: influence of clinical effectiveness and dosing frequency. Curr Med Res Opin. 2006;22(12):2375–81.CrossRefPubMed
23.
go back to reference Gold DT, Safi W, Trinh H. Patient preference and adherence: comparative US studies between two bisphosphonates, weekly risedronate and monthly ibandronate. Curr Med Res Opin. 2006;22(12):2383–91.CrossRefPubMed Gold DT, Safi W, Trinh H. Patient preference and adherence: comparative US studies between two bisphosphonates, weekly risedronate and monthly ibandronate. Curr Med Res Opin. 2006;22(12):2383–91.CrossRefPubMed
24.
go back to reference den Uyl D, Geusens PP, van Berkum FN, Houben HH, Jebbink MC, Lems WF. Patient preference and acceptability of calcium plus vitamin D3 supplementation: a randomised, open, cross-over trial. Clin Rheumatol. 2010;29(5):465–72.CrossRef den Uyl D, Geusens PP, van Berkum FN, Houben HH, Jebbink MC, Lems WF. Patient preference and acceptability of calcium plus vitamin D3 supplementation: a randomised, open, cross-over trial. Clin Rheumatol. 2010;29(5):465–72.CrossRef
25.
go back to reference Freemantle N, Satram-Hoang S, Tang ET, Kaur P, Macarios D, Siddhanti S, et al. Final results of the DAPS (Denosumab Adherence Preference Satisfaction) study: a 24-month, randomized, crossover comparison with alendronate in postmenopausal women. Osteoporos Int. 2012;23(1):317–26.PubMedCentralCrossRefPubMed Freemantle N, Satram-Hoang S, Tang ET, Kaur P, Macarios D, Siddhanti S, et al. Final results of the DAPS (Denosumab Adherence Preference Satisfaction) study: a 24-month, randomized, crossover comparison with alendronate in postmenopausal women. Osteoporos Int. 2012;23(1):317–26.PubMedCentralCrossRefPubMed
26.
go back to reference Bonnick SL, Silverman S, Tanner SB, Martens M, Bachmann G, Kohles JD, et al. Patient satisfaction in postmenopausal women treated with a weekly bisphosphonate transitioned to once-monthly ibandronate. J Womens Health (Larchmt). 2009;18(7):935–43.CrossRef Bonnick SL, Silverman S, Tanner SB, Martens M, Bachmann G, Kohles JD, et al. Patient satisfaction in postmenopausal women treated with a weekly bisphosphonate transitioned to once-monthly ibandronate. J Womens Health (Larchmt). 2009;18(7):935–43.CrossRef
27.
go back to reference Emkey R, Koltun W, Beusterien K, Seidman L, Kivitz A, Devas V, et al. Patient preference for once-monthly ibandronate versus once-weekly alendronate in a randomized, open-label, cross-over trial: the Boniva Alendronate Trial in Osteoporosis (BALTO). Curr Med Res Opin. 2005;21(12):1895–903.CrossRefPubMed Emkey R, Koltun W, Beusterien K, Seidman L, Kivitz A, Devas V, et al. Patient preference for once-monthly ibandronate versus once-weekly alendronate in a randomized, open-label, cross-over trial: the Boniva Alendronate Trial in Osteoporosis (BALTO). Curr Med Res Opin. 2005;21(12):1895–903.CrossRefPubMed
28.
go back to reference Kendler DL, McClung MR, Freemantle N, Lillestol M, Moffett AH, Borenstein J, et al. Adherence, preference, and satisfaction of postmenopausal women taking denosumab or alendronate. Osteoporos Int. 2011;22(6):1725–35.CrossRefPubMed Kendler DL, McClung MR, Freemantle N, Lillestol M, Moffett AH, Borenstein J, et al. Adherence, preference, and satisfaction of postmenopausal women taking denosumab or alendronate. Osteoporos Int. 2011;22(6):1725–35.CrossRefPubMed
29.
go back to reference Chung YS, Lim SK, Chung HY, Lee IK, Park IH, Kim GS, et al. Comparison of monthly ibandronate versus weekly risedronate in preference, convenience, and bone turnover markers in Korean postmenopausal osteoporotic women. Calcif Tissue Int. 2009;85(5):389–97.PubMedCentralCrossRefPubMed Chung YS, Lim SK, Chung HY, Lee IK, Park IH, Kim GS, et al. Comparison of monthly ibandronate versus weekly risedronate in preference, convenience, and bone turnover markers in Korean postmenopausal osteoporotic women. Calcif Tissue Int. 2009;85(5):389–97.PubMedCentralCrossRefPubMed
30.
go back to reference Hadji P, Minne H, Pfeifer M, Bourgeois P, Fardellone P, Licata A, et al. Treatment preference for monthly oral ibandronate and weekly oral alendronate in women with postmenopausal osteoporosis: a randomized, crossover study (BALTO II). Joint Bone Spine. 2008;75(3):303–10.CrossRefPubMed Hadji P, Minne H, Pfeifer M, Bourgeois P, Fardellone P, Licata A, et al. Treatment preference for monthly oral ibandronate and weekly oral alendronate in women with postmenopausal osteoporosis: a randomized, crossover study (BALTO II). Joint Bone Spine. 2008;75(3):303–10.CrossRefPubMed
31.
go back to reference Simon JA, Lewiecki EM, Smith ME, Petruschke RA, Wang L, Palmisano JJ. Patient preference for once-weekly alendronate 70 mg versus once-daily alendronate 10 mg: a multicenter, randomized, open-label, crossover study. Clin Ther. 2002;24(11):1871–86.CrossRefPubMed Simon JA, Lewiecki EM, Smith ME, Petruschke RA, Wang L, Palmisano JJ. Patient preference for once-weekly alendronate 70 mg versus once-daily alendronate 10 mg: a multicenter, randomized, open-label, crossover study. Clin Ther. 2002;24(11):1871–86.CrossRefPubMed
32.
go back to reference Vlak T, Kastelan D, Lozo P, Aljinovic J, Gradiser M, Mijic S, et al. Monthly or weekly bisphosphonate? Evaluation of satisfaction in patients with postmenopausal osteoporosis using OPSAT-Q questionnaire during the BOOSTER study in Croatia. Clin Rheumatol. 2011;30(12):1549–54.CrossRefPubMed Vlak T, Kastelan D, Lozo P, Aljinovic J, Gradiser M, Mijic S, et al. Monthly or weekly bisphosphonate? Evaluation of satisfaction in patients with postmenopausal osteoporosis using OPSAT-Q questionnaire during the BOOSTER study in Croatia. Clin Rheumatol. 2011;30(12):1549–54.CrossRefPubMed
33.
go back to reference Palacios S, Agodoa I, Bonnick S, Van den Bergh JP, Ferreira I, Ho PR, et al. Treatment satisfaction in postmenopausal women suboptimally adherent to bisphosphonates who transitioned to denosumab compared with risedronate or ibandronate. J Clin Endocrinol Metab. 2015;100(3):E487–92.CrossRefPubMed Palacios S, Agodoa I, Bonnick S, Van den Bergh JP, Ferreira I, Ho PR, et al. Treatment satisfaction in postmenopausal women suboptimally adherent to bisphosphonates who transitioned to denosumab compared with risedronate or ibandronate. J Clin Endocrinol Metab. 2015;100(3):E487–92.CrossRefPubMed
34.
go back to reference Kendler D, Kung AW, Fuleihan Gel H, Gonzalez Gonzalez JG, Gaines KA, Verbruggen N, et al. Patients with osteoporosis prefer once weekly to once daily dosing with alendronate. Maturitas. 2004;48(3):243–51.CrossRefPubMed Kendler D, Kung AW, Fuleihan Gel H, Gonzalez Gonzalez JG, Gaines KA, Verbruggen N, et al. Patients with osteoporosis prefer once weekly to once daily dosing with alendronate. Maturitas. 2004;48(3):243–51.CrossRefPubMed
35.
go back to reference Kastelan D, Lozo P, Stamenkovic D, Miskic B, Vlak T, Kolak Z, et al. Preference for weekly and monthly bisphosphonates among patients with postmenopausal osteoporosis: results from the Croatian PROMO Study. Clin Rheumatol. 2009;28(3):321–6.CrossRefPubMed Kastelan D, Lozo P, Stamenkovic D, Miskic B, Vlak T, Kolak Z, et al. Preference for weekly and monthly bisphosphonates among patients with postmenopausal osteoporosis: results from the Croatian PROMO Study. Clin Rheumatol. 2009;28(3):321–6.CrossRefPubMed
36.
go back to reference McClung M, Recker R, Miller P, Fiske D, Minkoff J, Kriegman A, et al. Intravenous zoledronic acid 5 mg in the treatment of postmenopausal women with low bone density previously treated with alendronate. Bone. 2007;41(1):122–8.CrossRefPubMed McClung M, Recker R, Miller P, Fiske D, Minkoff J, Kriegman A, et al. Intravenous zoledronic acid 5 mg in the treatment of postmenopausal women with low bone density previously treated with alendronate. Bone. 2007;41(1):122–8.CrossRefPubMed
38.
go back to reference Stacey D, Bennett CL, Barry MJ, Col NF, Eden KB, Holmes-Rovner M, et al. Decision aids for people facing health treatment or screening decisions. Cochrane Database Syst Rev. 2011;10:CD001431.PubMed Stacey D, Bennett CL, Barry MJ, Col NF, Eden KB, Holmes-Rovner M, et al. Decision aids for people facing health treatment or screening decisions. Cochrane Database Syst Rev. 2011;10:CD001431.PubMed
39.
go back to reference Braddock 3rd CH, Edwards KA, Hasenberg NM, Laidley TL, Levinson W. Informed decision making in outpatient practice: time to get back to basics. JAMA. 1999;282(24):2313–20.CrossRefPubMed Braddock 3rd CH, Edwards KA, Hasenberg NM, Laidley TL, Levinson W. Informed decision making in outpatient practice: time to get back to basics. JAMA. 1999;282(24):2313–20.CrossRefPubMed
40.
go back to reference Oshima Lee E, Emanuel EJ. Shared decision making to improve care and reduce costs. N Engl J Med. 2013;368(1):6–8.CrossRefPubMed Oshima Lee E, Emanuel EJ. Shared decision making to improve care and reduce costs. N Engl J Med. 2013;368(1):6–8.CrossRefPubMed
41.
go back to reference Clark MD, Determann D, Petrou S, Moro D, de Bekker-Grob EW. Discrete choice experiments in health economics: a review of the literature. PharmacoEconomics. 2014;32(9):883–902.CrossRefPubMed Clark MD, Determann D, Petrou S, Moro D, de Bekker-Grob EW. Discrete choice experiments in health economics: a review of the literature. PharmacoEconomics. 2014;32(9):883–902.CrossRefPubMed
42.•
go back to reference Bansback N, Trenaman L, Harrison M. How important is mode of administration in treatments for rheumatic diseases and related conditions? Curr Rheumatol Rep. 2015;17(6):514. Interesting review that discussed the importance of mode of administration in treatments for rheumatic diseases.CrossRefPubMed Bansback N, Trenaman L, Harrison M. How important is mode of administration in treatments for rheumatic diseases and related conditions? Curr Rheumatol Rep. 2015;17(6):514. Interesting review that discussed the importance of mode of administration in treatments for rheumatic diseases.CrossRefPubMed
Metadata
Title
A Review of Patient Preferences for Osteoporosis Drug Treatment
Authors
Mickaël Hiligsmann
Sandrine P. G. Bours
Annelies Boonen
Publication date
01-09-2015
Publisher
Springer US
Published in
Current Rheumatology Reports / Issue 9/2015
Print ISSN: 1523-3774
Electronic ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-015-0533-0

Other articles of this Issue 9/2015

Current Rheumatology Reports 9/2015 Go to the issue

Osteoarthritis (MB Goldring, Section Editor)

Bone Homeostasis and Repair: Forced Into Shape

RHEUMATOID ARTHRITIS (LW MORELAND, SECTION EDITOR)

Lipid and Metabolic Changes in Rheumatoid Arthritis

Inflammatory Muscle Disease (Myositis) (R Aggarwal, Section Editor)

Role of Jo-1 in the Immunopathogenesis of the Anti-synthetase Syndrome