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Current Rheumatology Reports
Published in: Current Rheumatology Reports 1/2015

01-01-2015 | Antiphospholipid Syndrome (D Erkan, Section Editor)

Pulmonary Hypertension in Antiphospholipid Syndrome

Authors: Stéphane Zuily, Denis Wahl

Published in: Current Rheumatology Reports | Issue 1/2015

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Abstract

Pulmonary hypertension (PH) is a rare but life-threatening condition in antiphospholipid syndrome (APS) patients with or without systemic lupus erythematosus (SLE). The definition of PH is based on hemodynamic parameters estimated by transthoracic echocardiography (TTE) and confirmed by right heart catheterization (RHC). New evidence suggests that antiphospholipid antibodies (aPL) in SLE patients increase the risk of PH; however, studies yield conflicting results. Hypotheses regarding the impact of aPL on PH include large vessel and microvascular thrombosis, and endothelial remodeling. Natural history of PH is progressive worsening mainly due to recurrent pulmonary embolism. The management in APS patients includes anticoagulation; patients undergoing pulmonary endarterectomy need to be closely monitored because of an increased risk of thrombotic complications.
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Metadata
Title
Pulmonary Hypertension in Antiphospholipid Syndrome
Authors
Stéphane Zuily
Denis Wahl
Publication date
01-01-2015
Publisher
Springer US
Published in
Current Rheumatology Reports / Issue 1/2015
Print ISSN: 1523-3774
Electronic ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-014-0478-8

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