Skip to main content
Top
Published in: Current Rheumatology Reports 1/2015

01-01-2015 | Osteoarthritis (MB Goldring, Section Editor)

Rotator Cuff Biology and Biomechanics: a Review of Normal and Pathological Conditions

Authors: Julianne Huegel, Alexis A. Williams, Louis J. Soslowsky

Published in: Current Rheumatology Reports | Issue 1/2015

Login to get access

Abstract

The glenohumeral joint is a complex anatomic structure commonly affected by injury such as tendinopathy and rotator cuff tears. This review presents an up-to-date overview of research on tendon biology and structure, shoulder joint motion and stability, tendon healing, and current and potential future repair strategies. Recent studies have provided information demonstrating the serious impact on uninjured tissues after a rotator cuff tear or other cause of altered shoulder joint mechanics. Another major focus of recent research is biological augmentation of rotator cuff repair with the goal of successfully reinstating normal tendon-to-bone structure. To effectively treat shoulder pathologies, clinicians need to understand normal tendon biology, the healing process and environment, and whole shoulder stability and function.
Literature
1.
go back to reference Llusa M, Meri A, Ruano D. Surgical atlas of the musculoskeletal system. Rosemont, Ill.: American Academy of Orthopaedic Surgeons. 2008. Llusa M, Meri A, Ruano D. Surgical atlas of the musculoskeletal system. Rosemont, Ill.: American Academy of Orthopaedic Surgeons. 2008.
2.
go back to reference Setton LA, Elliott DM, Mow VC. Altered mechanics of cartilage with osteoarthritis: human osteoarthritis and an experimental model of joint degeneration. Osteoarthr Cartil. 1999;7:2–14.PubMedCrossRef Setton LA, Elliott DM, Mow VC. Altered mechanics of cartilage with osteoarthritis: human osteoarthritis and an experimental model of joint degeneration. Osteoarthr Cartil. 1999;7:2–14.PubMedCrossRef
3.
go back to reference Mehta S, Gimbel JA, Soslowsky LJ. Etiologic and pathogenetic factors for rotator cuff tendinopathy. Clin Sports Med. 2003;22:791–812.PubMedCrossRef Mehta S, Gimbel JA, Soslowsky LJ. Etiologic and pathogenetic factors for rotator cuff tendinopathy. Clin Sports Med. 2003;22:791–812.PubMedCrossRef
4.
go back to reference De Maeseneer M, Van Roy P, Shahabpour M. Normal MR imaging anatomy of the rotator cuff tendons, glenoid fossa, labrum, and ligaments of the shoulder. Radiol Clin North Am. 2006;44:479–87. vii.PubMedCrossRef De Maeseneer M, Van Roy P, Shahabpour M. Normal MR imaging anatomy of the rotator cuff tendons, glenoid fossa, labrum, and ligaments of the shoulder. Radiol Clin North Am. 2006;44:479–87. vii.PubMedCrossRef
5.
go back to reference Clark JM, Harryman 2nd DT. Tendons, ligaments, and capsule of the rotator cuff. Gross and microscopic anatomy. J Bone Joint Surg Am. 1992;74:713–25.PubMed Clark JM, Harryman 2nd DT. Tendons, ligaments, and capsule of the rotator cuff. Gross and microscopic anatomy. J Bone Joint Surg Am. 1992;74:713–25.PubMed
6.
go back to reference Curtis AS, Burbank KM, Tierney JJ, Scheller AD, Curran AR. The insertional footprint of the rotator cuff: an anatomic study. Arthroscopy. 2006;22:609.e1.PubMedCrossRef Curtis AS, Burbank KM, Tierney JJ, Scheller AD, Curran AR. The insertional footprint of the rotator cuff: an anatomic study. Arthroscopy. 2006;22:609.e1.PubMedCrossRef
7.
go back to reference Thomopoulos S, Williams GR, Gimbel JA, Favata M, Soslowsky LJ. Variation of biomechanical, structural, and compositional properties along the tendon to bone insertion site. J Orthop Res. 2003;21:413–9.PubMedCrossRef Thomopoulos S, Williams GR, Gimbel JA, Favata M, Soslowsky LJ. Variation of biomechanical, structural, and compositional properties along the tendon to bone insertion site. J Orthop Res. 2003;21:413–9.PubMedCrossRef
8.
go back to reference Soslowsky LJ, Carpenter JE, Bucchieri JS, Flatow EL. Biomechanics of the rotator cuff. Orthop Clin North Am. 1997;28:17–30.PubMedCrossRef Soslowsky LJ, Carpenter JE, Bucchieri JS, Flatow EL. Biomechanics of the rotator cuff. Orthop Clin North Am. 1997;28:17–30.PubMedCrossRef
9.
go back to reference Gautieri A, Vesentini S, Redaelli A, Buehler MJ. Hierarchical structure and nanomechanics of collagen microfibrils from the atomistic scale up. Nano Lett. 2011;11:757–66.PubMedCrossRef Gautieri A, Vesentini S, Redaelli A, Buehler MJ. Hierarchical structure and nanomechanics of collagen microfibrils from the atomistic scale up. Nano Lett. 2011;11:757–66.PubMedCrossRef
10.
go back to reference Lake SP, Miller KS, Elliott DM, Soslowsky LJ. Effect of fiber distribution and realignment on the nonlinear and inhomogeneous mechanical properties of human supraspinatus tendon under longitudinal tensile loading. J Orthop Res. 2009;27:1596–602.PubMedCentralPubMedCrossRef Lake SP, Miller KS, Elliott DM, Soslowsky LJ. Effect of fiber distribution and realignment on the nonlinear and inhomogeneous mechanical properties of human supraspinatus tendon under longitudinal tensile loading. J Orthop Res. 2009;27:1596–602.PubMedCentralPubMedCrossRef
11.
go back to reference Miller KS, Edelstein L, Connizzo BK, Soslowsky LJ. Effect of preconditioning and stress relaxation on local collagen fiber re-alignment: inhomogeneous properties of rat supraspinatus tendon. J Biomech Eng. 2012;134:031007.PubMedCrossRef Miller KS, Edelstein L, Connizzo BK, Soslowsky LJ. Effect of preconditioning and stress relaxation on local collagen fiber re-alignment: inhomogeneous properties of rat supraspinatus tendon. J Biomech Eng. 2012;134:031007.PubMedCrossRef
12.
go back to reference Matsuhashi T, Hooke AW, Zhao KD, Goto A, Sperling JW, Steinmann SP, et al. Tensile properties of a morphologically split supraspinatus tendon. Clin Anat. 2014;27:702–6.PubMedCrossRef Matsuhashi T, Hooke AW, Zhao KD, Goto A, Sperling JW, Steinmann SP, et al. Tensile properties of a morphologically split supraspinatus tendon. Clin Anat. 2014;27:702–6.PubMedCrossRef
13.
go back to reference Bigliani LU, Pollock RG, Soslowsky LJ, Flatow EL, Pawluk RJ, Mow VC. Tensile properties of the inferior glenohumeral ligament. J Orthop Res. 1992;10:187–97.PubMedCrossRef Bigliani LU, Pollock RG, Soslowsky LJ, Flatow EL, Pawluk RJ, Mow VC. Tensile properties of the inferior glenohumeral ligament. J Orthop Res. 1992;10:187–97.PubMedCrossRef
14.
go back to reference Moore SM, Ellis B, Weiss JA, McMahon PJ, Debski RE. The glenohumeral capsule should be evaluated as a sheet of fibrous tissue: a validated finite element model. Ann Biomed Eng. 2010;38:66–76.PubMedCentralPubMedCrossRef Moore SM, Ellis B, Weiss JA, McMahon PJ, Debski RE. The glenohumeral capsule should be evaluated as a sheet of fibrous tissue: a validated finite element model. Ann Biomed Eng. 2010;38:66–76.PubMedCentralPubMedCrossRef
15.
go back to reference Bahk M, Keyurapan E, Tasaki A, Sauers EL, McFarland EG. Laxity testing of the shoulder: a review. Am J Sports Med. 2007;35:131–44.PubMedCrossRef Bahk M, Keyurapan E, Tasaki A, Sauers EL, McFarland EG. Laxity testing of the shoulder: a review. Am J Sports Med. 2007;35:131–44.PubMedCrossRef
16.
go back to reference Halder AM, Kuhl SG, Zobitz ME, Larson D, An KN. Effects of the glenoid labrum and glenohumeral abduction on stability of the shoulder joint through concavity-compression: an in vitro study. J Bone Joint Surg Am. 2001;83-A:1062–9.PubMed Halder AM, Kuhl SG, Zobitz ME, Larson D, An KN. Effects of the glenoid labrum and glenohumeral abduction on stability of the shoulder joint through concavity-compression: an in vitro study. J Bone Joint Surg Am. 2001;83-A:1062–9.PubMed
17.
go back to reference Turkel SJ, Panio MW, Marshall JL, Girgis FG. Stabilizing mechanisms preventing anterior dislocation of the glenohumeral joint. J Bone Joint Surg Am. 1981;63:1208–17.PubMed Turkel SJ, Panio MW, Marshall JL, Girgis FG. Stabilizing mechanisms preventing anterior dislocation of the glenohumeral joint. J Bone Joint Surg Am. 1981;63:1208–17.PubMed
18.
go back to reference Malicky DM, Soslowsky LJ, Blasier RB, Shyr Y. Anterior glenohumeral stabilization factors: progressive effects in a biomechanical model. J Orthop Res. 1996;14:282–8.PubMedCrossRef Malicky DM, Soslowsky LJ, Blasier RB, Shyr Y. Anterior glenohumeral stabilization factors: progressive effects in a biomechanical model. J Orthop Res. 1996;14:282–8.PubMedCrossRef
19.
go back to reference Soslowsky LJ, Malicky DM, Blasier RB. Active and passive factors in inferior glenohumeral stabilization: a biomechanical model. J Shoulder Elbow Surg. 1997;6:371–9.PubMedCrossRef Soslowsky LJ, Malicky DM, Blasier RB. Active and passive factors in inferior glenohumeral stabilization: a biomechanical model. J Shoulder Elbow Surg. 1997;6:371–9.PubMedCrossRef
20.
go back to reference Blasier RB, Soslowsky LJ, Malicky DM, Palmer ML. Posterior glenohumeral subluxation: active and passive stabilization in a biomechanical model. J Bone Joint Surg Am. 1997;79:433–40.PubMedCrossRef Blasier RB, Soslowsky LJ, Malicky DM, Palmer ML. Posterior glenohumeral subluxation: active and passive stabilization in a biomechanical model. J Bone Joint Surg Am. 1997;79:433–40.PubMedCrossRef
21.
go back to reference Lee TQ, Black AD, Tibone JE, McMahon PJ. Release of the coracoacromial ligament can lead to glenohumeral laxity: a biomechanical study. J Shoulder Elbow Surg. 2001;10:68–72.PubMedCrossRef Lee TQ, Black AD, Tibone JE, McMahon PJ. Release of the coracoacromial ligament can lead to glenohumeral laxity: a biomechanical study. J Shoulder Elbow Surg. 2001;10:68–72.PubMedCrossRef
22.
go back to reference Abboud JA, Soslowsky LJ. Interplay of the static and dynamic restraints in glenohumeral instability. Clin Orthop Relat Res. 2002;400:48–57.PubMedCrossRef Abboud JA, Soslowsky LJ. Interplay of the static and dynamic restraints in glenohumeral instability. Clin Orthop Relat Res. 2002;400:48–57.PubMedCrossRef
24.
go back to reference Moor BK, Bouaicha S, Rothenfluh DA, Sukthankar A, Gerber C. Is there an association between the individual anatomy of the scapula and the development of rotator cuff tears or osteoarthritis of the glenohumeral joint?: A radiological study of the critical shoulder angle. Bone Joint J. 2013;95-B:935–41.PubMedCrossRef Moor BK, Bouaicha S, Rothenfluh DA, Sukthankar A, Gerber C. Is there an association between the individual anatomy of the scapula and the development of rotator cuff tears or osteoarthritis of the glenohumeral joint?: A radiological study of the critical shoulder angle. Bone Joint J. 2013;95-B:935–41.PubMedCrossRef
25.
go back to reference Thompson WO, Debski RE, Boardman 3rd ND, Taskiran E, Warner JJ, Fu FH, et al. A biomechanical analysis of rotator cuff deficiency in a cadaveric model. Am J Sports Med. 1996;24:286–92.PubMedCrossRef Thompson WO, Debski RE, Boardman 3rd ND, Taskiran E, Warner JJ, Fu FH, et al. A biomechanical analysis of rotator cuff deficiency in a cadaveric model. Am J Sports Med. 1996;24:286–92.PubMedCrossRef
26.
go back to reference Parsons IM, Apreleva M, Fu FH, Woo SL. The effect of rotator cuff tears on reaction forces at the glenohumeral joint. J Orthop Res. 2002;20:439–46.PubMedCrossRef Parsons IM, Apreleva M, Fu FH, Woo SL. The effect of rotator cuff tears on reaction forces at the glenohumeral joint. J Orthop Res. 2002;20:439–46.PubMedCrossRef
27.
go back to reference Maeda E, Fleischmann C, Mein CA, Shelton JC, Bader DL, Lee DA. Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain. Connect Tissue Res. 2010;51:434–44.PubMedCrossRef Maeda E, Fleischmann C, Mein CA, Shelton JC, Bader DL, Lee DA. Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain. Connect Tissue Res. 2010;51:434–44.PubMedCrossRef
28.
go back to reference Arnoczky SP, Lavagnino M, Egerbacher M. The mechanobiological aetiopathogenesis of tendinopathy: is it the over-stimulation or the under-stimulation of tendon cells? Int J Exp Pathol. 2007;88:217–26.PubMedCentralPubMedCrossRef Arnoczky SP, Lavagnino M, Egerbacher M. The mechanobiological aetiopathogenesis of tendinopathy: is it the over-stimulation or the under-stimulation of tendon cells? Int J Exp Pathol. 2007;88:217–26.PubMedCentralPubMedCrossRef
29.
go back to reference Soslowsky LJ, Thomopoulos S, Tun S, Flanagan CL, Keefer CC, Mastaw J, et al. Neer Award 1999. Overuse activity injures the supraspinatus tendon in an animal model: a histologic and biomechanical study. J Shoulder Elbow Surg. 2000;9:79–84.PubMedCrossRef Soslowsky LJ, Thomopoulos S, Tun S, Flanagan CL, Keefer CC, Mastaw J, et al. Neer Award 1999. Overuse activity injures the supraspinatus tendon in an animal model: a histologic and biomechanical study. J Shoulder Elbow Surg. 2000;9:79–84.PubMedCrossRef
30.
go back to reference Archambault JM, Jelinsky SA, Lake SP, Hill AA, Glaser DL, Soslowsky LJ. Rat supraspinatus tendon expresses cartilage markers with overuse. J Orthop Res. 2007;25:617–24.PubMedCrossRef Archambault JM, Jelinsky SA, Lake SP, Hill AA, Glaser DL, Soslowsky LJ. Rat supraspinatus tendon expresses cartilage markers with overuse. J Orthop Res. 2007;25:617–24.PubMedCrossRef
31.•
go back to reference Attia M, Scott A, Duchesnay A, Carpentier G, Soslowsky LJ, Huynh MB, et al. Alterations of overused supraspinatus tendon: a possible role of glycosaminoglycans and HARP/pleiotrophin in early tendon pathology. J Orthop Res. 2012;30:61–71. In a rat model, GAG expression and accumulation after 4 weeks of overuse continues for up to 16 weeks and may sequester the HARP cytokine, influencing tenocyte phenotype. PubMedCrossRef Attia M, Scott A, Duchesnay A, Carpentier G, Soslowsky LJ, Huynh MB, et al. Alterations of overused supraspinatus tendon: a possible role of glycosaminoglycans and HARP/pleiotrophin in early tendon pathology. J Orthop Res. 2012;30:61–71. In a rat model, GAG expression and accumulation after 4 weeks of overuse continues for up to 16 weeks and may sequester the HARP cytokine, influencing tenocyte phenotype. PubMedCrossRef
32.
go back to reference Millar NL, Wei AQ, Molloy TJ, Bonar F, Murrell GA. Cytokines and apoptosis in supraspinatus tendinopathy. J Bone Joint Surg (Br). 2009;91:417–24.CrossRef Millar NL, Wei AQ, Molloy TJ, Bonar F, Murrell GA. Cytokines and apoptosis in supraspinatus tendinopathy. J Bone Joint Surg (Br). 2009;91:417–24.CrossRef
33.
go back to reference Perry SM, McIlhenny SE, Hoffman MC, Soslowsky LJ. Inflammatory and angiogenic mRNA levels are altered in a supraspinatus tendon overuse animal model. J Shoulder Elbow Surg. 2005;14:79S–83.PubMedCrossRef Perry SM, McIlhenny SE, Hoffman MC, Soslowsky LJ. Inflammatory and angiogenic mRNA levels are altered in a supraspinatus tendon overuse animal model. J Shoulder Elbow Surg. 2005;14:79S–83.PubMedCrossRef
34.
go back to reference de Castro PA, Ejnisman B, de Seixas Alves MT, Uyeda LF, Nouailhetas VL, Han SW, et al. Overuse of training increases mechanoreceptors in supraspinatus tendon of rats SHR. J Orthop Res. 2011;29:1771–4.CrossRef de Castro PA, Ejnisman B, de Seixas Alves MT, Uyeda LF, Nouailhetas VL, Han SW, et al. Overuse of training increases mechanoreceptors in supraspinatus tendon of rats SHR. J Orthop Res. 2011;29:1771–4.CrossRef
35.
go back to reference Maganaris CN, Narici MV, Almekinders LC, Maffulli N. Biomechanics and pathophysiology of overuse tendon injuries: ideas on insertional tendinopathy. Sports Med. 2004;34:1005–17.PubMedCrossRef Maganaris CN, Narici MV, Almekinders LC, Maffulli N. Biomechanics and pathophysiology of overuse tendon injuries: ideas on insertional tendinopathy. Sports Med. 2004;34:1005–17.PubMedCrossRef
36.
go back to reference Magnusson SP, Langberg H, Kjaer M. The pathogenesis of tendinopathy: balancing the response to loading. Nat Rev Rheumatol. 2010;6:262–8.PubMedCrossRef Magnusson SP, Langberg H, Kjaer M. The pathogenesis of tendinopathy: balancing the response to loading. Nat Rev Rheumatol. 2010;6:262–8.PubMedCrossRef
37.
go back to reference Neer 2nd CS. Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. J Bone Joint Surg Am. 1972;54:41–50.PubMed Neer 2nd CS. Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. J Bone Joint Surg Am. 1972;54:41–50.PubMed
38.
go back to reference Evanko SP, Vogel KG. Proteoglycan synthesis in fetal tendon is differentially regulated by cyclic compression in vitro. Arch Biochem Biophys. 1993;307:153–64.PubMedCrossRef Evanko SP, Vogel KG. Proteoglycan synthesis in fetal tendon is differentially regulated by cyclic compression in vitro. Arch Biochem Biophys. 1993;307:153–64.PubMedCrossRef
39.
go back to reference McFarland EG, Maffulli N, Del Buono A, Murrell GA, Garzon-Muvdi J, Petersen SA. Impingement is not impingement: the case for calling it “Rotator Cuff Disease”. Muscles Ligaments Tendons J. 2013;3:196–200.PubMedCentralPubMed McFarland EG, Maffulli N, Del Buono A, Murrell GA, Garzon-Muvdi J, Petersen SA. Impingement is not impingement: the case for calling it “Rotator Cuff Disease”. Muscles Ligaments Tendons J. 2013;3:196–200.PubMedCentralPubMed
40.
go back to reference Papadonikolakis A, McKenna M, Warme W, Martin BI, 3rd Matsen FA. Published evidence relevant to the diagnosis of impingement syndrome of the shoulder. J Bone Joint Surg Am. 2011;93:1827–32.PubMedCrossRef Papadonikolakis A, McKenna M, Warme W, Martin BI, 3rd Matsen FA. Published evidence relevant to the diagnosis of impingement syndrome of the shoulder. J Bone Joint Surg Am. 2011;93:1827–32.PubMedCrossRef
41.
go back to reference Shi LL, Edwards TB. The role of acromioplasty for management of rotator cuff problems: where is the evidence? Adv Orthop. 2012;2012:467571.PubMedCentralPubMed Shi LL, Edwards TB. The role of acromioplasty for management of rotator cuff problems: where is the evidence? Adv Orthop. 2012;2012:467571.PubMedCentralPubMed
42.
go back to reference Fung DT, Wang VM, Andarawis-Puri N, Basta-Pljakic J, Li Y, Laudier DM, et al. Early response to tendon fatigue damage accumulation in a novel in vivo model. J Biomech. 2010;43:274–9.PubMedCentralPubMedCrossRef Fung DT, Wang VM, Andarawis-Puri N, Basta-Pljakic J, Li Y, Laudier DM, et al. Early response to tendon fatigue damage accumulation in a novel in vivo model. J Biomech. 2010;43:274–9.PubMedCentralPubMedCrossRef
43.•
go back to reference Frisch KE, Marcu D, Baer GS, Thelen DG, Vanderby R. The influence of partial and full thickness tears on infraspinatus tendon strain patterns. J Biomech Eng. 2014;136:051004. Investigates tendon strain patterns after defect formation, determining that tendons are more sensitive to bursal defects and localized strain is induced directly next to partial thickness tears. PubMedCrossRef Frisch KE, Marcu D, Baer GS, Thelen DG, Vanderby R. The influence of partial and full thickness tears on infraspinatus tendon strain patterns. J Biomech Eng. 2014;136:051004. Investigates tendon strain patterns after defect formation, determining that tendons are more sensitive to bursal defects and localized strain is induced directly next to partial thickness tears. PubMedCrossRef
44.
go back to reference Oh JH, Jun BJ, McGarry MH, Lee TQ. Does a critical rotator cuff tear stage exist?: a biomechanical study of rotator cuff tear progression in human cadaver shoulders. J Bone Joint Surg Am. 2011;93:2100–9.PubMed Oh JH, Jun BJ, McGarry MH, Lee TQ. Does a critical rotator cuff tear stage exist?: a biomechanical study of rotator cuff tear progression in human cadaver shoulders. J Bone Joint Surg Am. 2011;93:2100–9.PubMed
45.
go back to reference Mesiha MM, Derwin KA, Sibole SC, Erdemir A, McCarron JA. The biomechanical relevance of anterior rotator cuff cable tears in a cadaveric shoulder model. J Bone Joint Surg Am. 2013;95:1817–24.PubMedCrossRef Mesiha MM, Derwin KA, Sibole SC, Erdemir A, McCarron JA. The biomechanical relevance of anterior rotator cuff cable tears in a cadaveric shoulder model. J Bone Joint Surg Am. 2013;95:1817–24.PubMedCrossRef
46.
go back to reference Hsu JE, Reuther KE, Sarver JJ, Lee CS, Thomas SJ, Glaser DL, et al. Restoration of anterior-posterior rotator cuff force balance improves shoulder function in a rat model of chronic massive tears. J Orthop Res. 2011;29:1028–33.PubMedCentralPubMedCrossRef Hsu JE, Reuther KE, Sarver JJ, Lee CS, Thomas SJ, Glaser DL, et al. Restoration of anterior-posterior rotator cuff force balance improves shoulder function in a rat model of chronic massive tears. J Orthop Res. 2011;29:1028–33.PubMedCentralPubMedCrossRef
47.
go back to reference Hwang E, Carpenter JE, Hughes RE, Palmer ML. Shoulder labral pathomechanics with rotator cuff tears. J Biomech. 2014;47:1733–8.PubMedCrossRef Hwang E, Carpenter JE, Hughes RE, Palmer ML. Shoulder labral pathomechanics with rotator cuff tears. J Biomech. 2014;47:1733–8.PubMedCrossRef
48.•
go back to reference Reuther KE, Sarver JJ, Schultz SM, Lee CS, Sehgal CM, Glaser DL, et al. Glenoid cartilage mechanical properties decrease after rotator cuff tears in a rat model. J Orthop Res. 2012;30:1435–9. Demonstrates changes in articular cartilage of the glenoid after rotator cuff tear in a rat model. PubMedCentralPubMedCrossRef Reuther KE, Sarver JJ, Schultz SM, Lee CS, Sehgal CM, Glaser DL, et al. Glenoid cartilage mechanical properties decrease after rotator cuff tears in a rat model. J Orthop Res. 2012;30:1435–9. Demonstrates changes in articular cartilage of the glenoid after rotator cuff tear in a rat model. PubMedCentralPubMedCrossRef
49.
go back to reference Reuther KE, Thomas SJ, Evans EF, Tucker JJ, Sarver JJ, Ilkhani-Pour S, et al. Returning to overuse activity following a supraspinatus and infraspinatus tear leads to joint damage in a rat model. J Biomech. 2013;46:1818–24.PubMedCentralPubMedCrossRef Reuther KE, Thomas SJ, Evans EF, Tucker JJ, Sarver JJ, Ilkhani-Pour S, et al. Returning to overuse activity following a supraspinatus and infraspinatus tear leads to joint damage in a rat model. J Biomech. 2013;46:1818–24.PubMedCentralPubMedCrossRef
50.
go back to reference Kramer EJ, Bodendorfer BM, Laron D, Wong J, Kim HT, Liu X, et al. Evaluation of cartilage degeneration in a rat model of rotator cuff tear arthropathy. J Shoulder Elbow Surg. 2013;22:1702–9.PubMedCrossRef Kramer EJ, Bodendorfer BM, Laron D, Wong J, Kim HT, Liu X, et al. Evaluation of cartilage degeneration in a rat model of rotator cuff tear arthropathy. J Shoulder Elbow Surg. 2013;22:1702–9.PubMedCrossRef
51.
go back to reference Reuther KE, Thomas SJ, Sarver JJ, Tucker JJ, Lee CS, Gray CF, et al. Effect of return to overuse activity following an isolated supraspinatus tendon tear on adjacent intact tendons and glenoid cartilage in a rat model. J Orthop Res. 2013;31:710–5.PubMedCentralPubMedCrossRef Reuther KE, Thomas SJ, Sarver JJ, Tucker JJ, Lee CS, Gray CF, et al. Effect of return to overuse activity following an isolated supraspinatus tendon tear on adjacent intact tendons and glenoid cartilage in a rat model. J Orthop Res. 2013;31:710–5.PubMedCentralPubMedCrossRef
52.••
go back to reference Reuther KE, Thomas SJ, Tucker JJ, Sarver JJ, Gray CF, Rooney SI, et al. Disruption of the anterior-posterior rotator cuff force balance alters joint function and leads to joint damage in a rat model. J Orthop Res. 2014;32:638–44. This study brings to light the damaging effects of shoulder instability after rotator cuff tears. PubMedCentralPubMedCrossRef Reuther KE, Thomas SJ, Tucker JJ, Sarver JJ, Gray CF, Rooney SI, et al. Disruption of the anterior-posterior rotator cuff force balance alters joint function and leads to joint damage in a rat model. J Orthop Res. 2014;32:638–44. This study brings to light the damaging effects of shoulder instability after rotator cuff tears. PubMedCentralPubMedCrossRef
53.•
go back to reference Ditsios K, Boutsiadis A, Kapoukranidou D, Chatzisotiriou A, Kalpidis I, Albani M, et al. Chronic massive rotator cuff tear in rats: in vivo evaluation of muscle force and three-dimensional histologic analysis. J Shoulder Elbow Surg. 2014. A thorough review of biceps tendinopathy and treatment options, focusing on comorbidity of the rotator cuff. doi:10.1016/j.jse.2014.04.016 Ditsios K, Boutsiadis A, Kapoukranidou D, Chatzisotiriou A, Kalpidis I, Albani M, et al. Chronic massive rotator cuff tear in rats: in vivo evaluation of muscle force and three-dimensional histologic analysis. J Shoulder Elbow Surg. 2014. A thorough review of biceps tendinopathy and treatment options, focusing on comorbidity of the rotator cuff. doi:10.​1016/​j.​jse.​2014.​04.​016
54.
go back to reference Sato EJ, Killian ML, Choi AJ, Lin E, Esparza MC, Galatz LM, et al. Skeletal muscle fibrosis and stiffness increase after rotator cuff tendon injury and neuromuscular compromise in a rat model. J Orthop Res. 2014;32:1111–6.PubMedCrossRef Sato EJ, Killian ML, Choi AJ, Lin E, Esparza MC, Galatz LM, et al. Skeletal muscle fibrosis and stiffness increase after rotator cuff tendon injury and neuromuscular compromise in a rat model. J Orthop Res. 2014;32:1111–6.PubMedCrossRef
55.
go back to reference Kikukawa K, Ide J, Kikuchi K, Morita M, Mizuta H, Ogata H. Hypertrophic changes of the teres minor muscle in rotator cuff tears: quantitative evaluation by magnetic resonance imaging. J Shoulder Elbow Surg. 2014. doi:10.1016/j.jse.2014.03.014 Kikukawa K, Ide J, Kikuchi K, Morita M, Mizuta H, Ogata H. Hypertrophic changes of the teres minor muscle in rotator cuff tears: quantitative evaluation by magnetic resonance imaging. J Shoulder Elbow Surg. 2014. doi:10.​1016/​j.​jse.​2014.​03.​014
56.
go back to reference Chen CH, Hsu KY, Chen WJ, Shih CH. Incidence and severity of biceps long head tendon lesion in patients with complete rotator cuff tears. J Trauma. 2005;58:1189–93.PubMedCrossRef Chen CH, Hsu KY, Chen WJ, Shih CH. Incidence and severity of biceps long head tendon lesion in patients with complete rotator cuff tears. J Trauma. 2005;58:1189–93.PubMedCrossRef
57.
go back to reference Wu PT, Jou IM, Yang CC, Lin CJ, Yang CY, Su FC, et al. The severity of the long head biceps tendinopathy in patients with chronic rotator cuff tears: macroscopic versus microscopic results. J Shoulder Elbow Surg. 2014;23:1099–106.PubMedCrossRef Wu PT, Jou IM, Yang CC, Lin CJ, Yang CY, Su FC, et al. The severity of the long head biceps tendinopathy in patients with chronic rotator cuff tears: macroscopic versus microscopic results. J Shoulder Elbow Surg. 2014;23:1099–106.PubMedCrossRef
58.
go back to reference Peltz CD, Perry SM, Getz CL, Soslowsky LJ. Mechanical properties of the long-head of the biceps tendon are altered in the presence of rotator cuff tears in a rat model. J Orthop Res. 2009;27:416–20.PubMedCentralPubMedCrossRef Peltz CD, Perry SM, Getz CL, Soslowsky LJ. Mechanical properties of the long-head of the biceps tendon are altered in the presence of rotator cuff tears in a rat model. J Orthop Res. 2009;27:416–20.PubMedCentralPubMedCrossRef
59.
go back to reference Ditsios K, Agathangelidis F, Boutsiadis A, Karataglis D, Papadopoulos P. Long head of the biceps pathology combined with rotator cuff tears. Adv Orthop. 2012;2012:405472.PubMedCentralPubMedCrossRef Ditsios K, Agathangelidis F, Boutsiadis A, Karataglis D, Papadopoulos P. Long head of the biceps pathology combined with rotator cuff tears. Adv Orthop. 2012;2012:405472.PubMedCentralPubMedCrossRef
60.•
go back to reference Giphart JE, Elser F, Dewing CB, Torry MR, Millett PJ. The long head of the biceps tendon has minimal effect on in vivo glenohumeral kinematics: a biplane fluoroscopy study. Am J Sports Med. 2012;40:202–12. Comparison of mechanics between tenodesed shoulders and healthy contralateral controls in five patients. No dramatic alterations in glenohumeral positioning during dynamic motion were seen, suggesting a low probability of long-term effects after such treatment. PubMedCrossRef Giphart JE, Elser F, Dewing CB, Torry MR, Millett PJ. The long head of the biceps tendon has minimal effect on in vivo glenohumeral kinematics: a biplane fluoroscopy study. Am J Sports Med. 2012;40:202–12. Comparison of mechanics between tenodesed shoulders and healthy contralateral controls in five patients. No dramatic alterations in glenohumeral positioning during dynamic motion were seen, suggesting a low probability of long-term effects after such treatment. PubMedCrossRef
61.•
go back to reference Zhang Q, Zhou J, Ge H, Cheng B. Tenotomy or tenodesis for long head biceps lesions in shoulders with reparable rotator cuff tears: a prospective randomised trial. Knee Surg Sports Traumatol Arthrosc. 2013. Well-designed prospective trial on treatment of LH biceps lesions in conjunction with rotator cuff repair. doi:10.1007/s00167-013-2587-8 Zhang Q, Zhou J, Ge H, Cheng B. Tenotomy or tenodesis for long head biceps lesions in shoulders with reparable rotator cuff tears: a prospective randomised trial. Knee Surg Sports Traumatol Arthrosc. 2013. Well-designed prospective trial on treatment of LH biceps lesions in conjunction with rotator cuff repair. doi:10.​1007/​s00167-013-2587-8
62.•
go back to reference Thomas SJ, Reuther KE, Tucker JJ, Sarver JJ, Yannascoli SM, Caro AC, et al. Biceps detachment decreases joint damage in a rotator cuff tear rat model. Clin Orthop Relat Res. 2014;472:2404–12. Biceps tenotomy concurrent with rotator cuff tear improves joint function and decreases secondary joint damage compared to rotator cuff tear alone. PubMedCrossRef Thomas SJ, Reuther KE, Tucker JJ, Sarver JJ, Yannascoli SM, Caro AC, et al. Biceps detachment decreases joint damage in a rotator cuff tear rat model. Clin Orthop Relat Res. 2014;472:2404–12. Biceps tenotomy concurrent with rotator cuff tear improves joint function and decreases secondary joint damage compared to rotator cuff tear alone. PubMedCrossRef
63.
go back to reference Ricchetti ET, Aurora A, Iannotti JP, Derwin KA. Scaffold devices for rotator cuff repair. J Shoulder Elbow Surg. 2012;21:251–65.PubMedCrossRef Ricchetti ET, Aurora A, Iannotti JP, Derwin KA. Scaffold devices for rotator cuff repair. J Shoulder Elbow Surg. 2012;21:251–65.PubMedCrossRef
64.
go back to reference Bishop J, Klepps S, Lo IK, Bird J, Gladstone JN, Flatow EL. Cuff integrity after arthroscopic versus open rotator cuff repair: a prospective study. J Shoulder Elbow Surg. 2006;15:290–9.PubMedCrossRef Bishop J, Klepps S, Lo IK, Bird J, Gladstone JN, Flatow EL. Cuff integrity after arthroscopic versus open rotator cuff repair: a prospective study. J Shoulder Elbow Surg. 2006;15:290–9.PubMedCrossRef
66.
go back to reference Aleem AW, Brophy RH. Outcomes of rotator cuff surgery: what does the evidence tell us? Clin Sports Med. 2012;31:665–74.PubMedCrossRef Aleem AW, Brophy RH. Outcomes of rotator cuff surgery: what does the evidence tell us? Clin Sports Med. 2012;31:665–74.PubMedCrossRef
67.
go back to reference Burkhart SS, Denard PJ, Konicek J, Hanypsiak BT. Biomechanical validation of load-sharing rip-stop fixation for the repair of tissue-deficient rotator cuff tears. Am J Sports Med. 2014;42:457–62.PubMedCrossRef Burkhart SS, Denard PJ, Konicek J, Hanypsiak BT. Biomechanical validation of load-sharing rip-stop fixation for the repair of tissue-deficient rotator cuff tears. Am J Sports Med. 2014;42:457–62.PubMedCrossRef
68.
go back to reference Gartsman GM, Drake G, Edwards TB, Elkousy HA, Hammerman SM, O’Connor DP, et al. Ultrasound evaluation of arthroscopic full-thickness supraspinatus rotator cuff repair: single-row versus double-row suture bridge (transosseous equivalent) fixation. Results of a prospective, randomized study. J Shoulder Elbow Surg. 2013;22:1480–7.PubMedCrossRef Gartsman GM, Drake G, Edwards TB, Elkousy HA, Hammerman SM, O’Connor DP, et al. Ultrasound evaluation of arthroscopic full-thickness supraspinatus rotator cuff repair: single-row versus double-row suture bridge (transosseous equivalent) fixation. Results of a prospective, randomized study. J Shoulder Elbow Surg. 2013;22:1480–7.PubMedCrossRef
69.
go back to reference McCormick F, Gupta A, Bruce B, Harris J, Abrams G, Wilson H, et al. Single-row, double-row, and transosseous equivalent techniques for isolated supraspinatus tendon tears with minimal atrophy: a retrospective comparative outcome and radiographic analysis at minimum 2-year follow up. Int J Shoulder Surg. 2014;8:15–20.PubMedCentralPubMedCrossRef McCormick F, Gupta A, Bruce B, Harris J, Abrams G, Wilson H, et al. Single-row, double-row, and transosseous equivalent techniques for isolated supraspinatus tendon tears with minimal atrophy: a retrospective comparative outcome and radiographic analysis at minimum 2-year follow up. Int J Shoulder Surg. 2014;8:15–20.PubMedCentralPubMedCrossRef
70.
go back to reference Peltz CD, Sarver JJ, Dourte LM, Wurgler-Hauri CC, Williams GR, Soslowsky LJ. Exercise following a short immobilization period is detrimental to tendon properties and joint mechanics in a rat rotator cuff injury model. J Orthop Res. 2010;28:841–5.PubMedCentralPubMed Peltz CD, Sarver JJ, Dourte LM, Wurgler-Hauri CC, Williams GR, Soslowsky LJ. Exercise following a short immobilization period is detrimental to tendon properties and joint mechanics in a rat rotator cuff injury model. J Orthop Res. 2010;28:841–5.PubMedCentralPubMed
71.
go back to reference Lafosse L, Lanz U, Saintmard B, Campens C. Arthroscopic repair of subscapularis tear: surgical technique and results. Orthop Traumatol Surg Res. 2010;96:S99–108.PubMedCrossRef Lafosse L, Lanz U, Saintmard B, Campens C. Arthroscopic repair of subscapularis tear: surgical technique and results. Orthop Traumatol Surg Res. 2010;96:S99–108.PubMedCrossRef
72.••
go back to reference Edwards SL, Lynch TS, Saltzman MD, Terry MA, Nuber GW. Biologic and pharmacologic augmentation of rotator cuff repairs. J Am Acad Orthop Surg. 2011;19:583–9. Reviews recent approaches taken to augment the healing response after surgical repair of a torn rotator cuff. PubMed Edwards SL, Lynch TS, Saltzman MD, Terry MA, Nuber GW. Biologic and pharmacologic augmentation of rotator cuff repairs. J Am Acad Orthop Surg. 2011;19:583–9. Reviews recent approaches taken to augment the healing response after surgical repair of a torn rotator cuff. PubMed
73.
go back to reference Edelstein L, Thomas SJ, Soslowsky LJ. Rotator cuff tears: what have we learned from animal models? J Musculoskelet Neuronal Interact. 2011;11:150–62.PubMed Edelstein L, Thomas SJ, Soslowsky LJ. Rotator cuff tears: what have we learned from animal models? J Musculoskelet Neuronal Interact. 2011;11:150–62.PubMed
74.
go back to reference Gimbel JA, Van Kleunen JP, Mehta S, Perry SM, Williams GR, Soslowsky LJ. Supraspinatus tendon organizational and mechanical properties in a chronic rotator cuff tear animal model. J Biomech. 2004;37:739–49.PubMedCrossRef Gimbel JA, Van Kleunen JP, Mehta S, Perry SM, Williams GR, Soslowsky LJ. Supraspinatus tendon organizational and mechanical properties in a chronic rotator cuff tear animal model. J Biomech. 2004;37:739–49.PubMedCrossRef
75.••
go back to reference Mall NA, Tanaka MJ, Choi LS, Paletta Jr GA. Factors affecting rotator cuff healing. J Bone Joint Surg Am. 2014;96:778–88. Thorough review of surgical techniques, rehab protocols, and patient-specific factors influencing outcomes of rotator cuff repair. PubMedCrossRef Mall NA, Tanaka MJ, Choi LS, Paletta Jr GA. Factors affecting rotator cuff healing. J Bone Joint Surg Am. 2014;96:778–88. Thorough review of surgical techniques, rehab protocols, and patient-specific factors influencing outcomes of rotator cuff repair. PubMedCrossRef
76.
go back to reference Ilkhani-Pour S, Dunkman A, Solsowsky L. The basic science of rotator cuff tendons and healing. In: Nicholson GP, editor. Orthopaedic knowledge update: shoulder and elbow. 4th ed. Rosemont: American Academy of Orthopaedic Surgeons; 2013. p. 13–29. Ilkhani-Pour S, Dunkman A, Solsowsky L. The basic science of rotator cuff tendons and healing. In: Nicholson GP, editor. Orthopaedic knowledge update: shoulder and elbow. 4th ed. Rosemont: American Academy of Orthopaedic Surgeons; 2013. p. 13–29.
77.•
go back to reference Hoppe S, Alini M, Benneker LM, Milz S, Boileau P, Zumstein MA. Tenocytes of chronic rotator cuff tendon tears can be stimulated by platelet-released growth factors. J Shoulder Elbow Surg. 2013;22:340–9. Tendon cells taken from patients with chronic rotator cuff tears have inherently low proliferative capacity and collagen production. Supplementing media with 10% PRGFs substantially increased cell proliferation (>fourfold) and extracellular matrix expression (>10,000-fold).PubMedCrossRef Hoppe S, Alini M, Benneker LM, Milz S, Boileau P, Zumstein MA. Tenocytes of chronic rotator cuff tendon tears can be stimulated by platelet-released growth factors. J Shoulder Elbow Surg. 2013;22:340–9. Tendon cells taken from patients with chronic rotator cuff tears have inherently low proliferative capacity and collagen production. Supplementing media with 10% PRGFs substantially increased cell proliferation (>fourfold) and extracellular matrix expression (>10,000-fold).PubMedCrossRef
78.
go back to reference Galatz LM, Sandell LJ, Rothermich SY, Das R, Mastny A, Havlioglu N, et al. Characteristics of the rat supraspinatus tendon during tendon-to-bone healing after acute injury. J Orthop Res. 2006;24:541–50.PubMedCrossRef Galatz LM, Sandell LJ, Rothermich SY, Das R, Mastny A, Havlioglu N, et al. Characteristics of the rat supraspinatus tendon during tendon-to-bone healing after acute injury. J Orthop Res. 2006;24:541–50.PubMedCrossRef
79.
go back to reference Kovacevic D, Fox AJ, Bedi A, Ying L, Deng XH, Warren RF, et al. Calcium-phosphate matrix with or without TGF-beta3 improves tendon-bone healing after rotator cuff repair. Am J Sports Med. 2011;39:811–9.PubMedCrossRef Kovacevic D, Fox AJ, Bedi A, Ying L, Deng XH, Warren RF, et al. Calcium-phosphate matrix with or without TGF-beta3 improves tendon-bone healing after rotator cuff repair. Am J Sports Med. 2011;39:811–9.PubMedCrossRef
80.
go back to reference Mazzocca AD, McCarthy MB, Chowaniec D, Cote MP, Judson CH, Apostolakos J, et al. Bone marrow-derived mesenchymal stem cells obtained during arthroscopic rotator cuff repair surgery show potential for tendon cell differentiation after treatment with insulin. Arthroscopy. 2011;27:1459–71.PubMedCrossRef Mazzocca AD, McCarthy MB, Chowaniec D, Cote MP, Judson CH, Apostolakos J, et al. Bone marrow-derived mesenchymal stem cells obtained during arthroscopic rotator cuff repair surgery show potential for tendon cell differentiation after treatment with insulin. Arthroscopy. 2011;27:1459–71.PubMedCrossRef
81.
go back to reference Wong I, Burns J, Snyder S. Arthroscopic GraftJacket repair of rotator cuff tears. J Shoulder Elbow Surg. 2010;19:104–9.PubMedCrossRef Wong I, Burns J, Snyder S. Arthroscopic GraftJacket repair of rotator cuff tears. J Shoulder Elbow Surg. 2010;19:104–9.PubMedCrossRef
Metadata
Title
Rotator Cuff Biology and Biomechanics: a Review of Normal and Pathological Conditions
Authors
Julianne Huegel
Alexis A. Williams
Louis J. Soslowsky
Publication date
01-01-2015
Publisher
Springer US
Published in
Current Rheumatology Reports / Issue 1/2015
Print ISSN: 1523-3774
Electronic ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-014-0476-x

Other articles of this Issue 1/2015

Current Rheumatology Reports 1/2015 Go to the issue

Antiphospholipid Syndrome (D Erkan, Section Editor)

Catastrophic APS in the Context of Other Thrombotic Microangiopathies

Antiphospholipid Syndrome (D Erkan, Section Editor)

Pulmonary Hypertension in Antiphospholipid Syndrome

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine