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Published in: Current Osteoporosis Reports 3/2018

01-06-2018 | Craniofacial Skeleton (WE Roberts, Section Editor)

Endemic Molar Incisor Hypomineralization: a Pandemic Problem That Requires Monitoring by the Entire Health Care Community

Authors: Paul M. Schneider, Margarita Silva

Published in: Current Osteoporosis Reports | Issue 3/2018

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Abstract

Purpose of Review

This review brings a major, previously under-recognized dental and general health problem to the attention of the medical and scientific community. The goals are to help clinicians make early diagnoses, thereby improving treatment outcomes, and to stimulate increasing research efforts to understand the etiology and ultimately prevention.

Recent Findings

There are two recent systematic reviews of molar incisor hypomineralization (MIH). One reveals the global burden of the condition; mean global prevalence is 13% with 878 million people affected, with 4.8 million cases per year requiring treatment. The review into etiology found a lack of definitive knowledge, but that it is likely to be multifactorial, with childhood illness including fever possibly implicated.

Summary

The review presents details of MIH sufficient to enable clinicians to recognize it and understand its impact on affected children, its management, and the importance of early intervention. Much further research is needed.
Literature
1.
go back to reference Weerheijm K, Jälevik B, Alaluusua S. Molar–incisor hypomineralisation. Caries Res. 2001;35(5):390–1.CrossRefPubMed Weerheijm K, Jälevik B, Alaluusua S. Molar–incisor hypomineralisation. Caries Res. 2001;35(5):390–1.CrossRefPubMed
2.
go back to reference Rodd HD, Boissonade FM, Day PF. Pulpal status of hypomineralized permanent molars. Pediatr Dent. 2007;29(6):514–20.PubMed Rodd HD, Boissonade FM, Day PF. Pulpal status of hypomineralized permanent molars. Pediatr Dent. 2007;29(6):514–20.PubMed
3.
4.
go back to reference Elfrink M, Schuller A, Weerheijm K, Veerkamp J. Hypomineralized second primary molars: prevalence data in Dutch 5-year-olds. Caries Res. 2008;42(4):282–5.CrossRefPubMed Elfrink M, Schuller A, Weerheijm K, Veerkamp J. Hypomineralized second primary molars: prevalence data in Dutch 5-year-olds. Caries Res. 2008;42(4):282–5.CrossRefPubMed
5.
go back to reference Sabel N, Johansson C, Kühnisch J, Robertson A, Steiniger F, Norén JG, et al. Neonatal lines in the enamel of primary teeth—a morphological and scanning electron microscopic investigation. Arch Oral Biol. 2008;53(10):954–63.CrossRefPubMed Sabel N, Johansson C, Kühnisch J, Robertson A, Steiniger F, Norén JG, et al. Neonatal lines in the enamel of primary teeth—a morphological and scanning electron microscopic investigation. Arch Oral Biol. 2008;53(10):954–63.CrossRefPubMed
6.
go back to reference •• Anthonappa RP, King NM. Enamel defects in the permanent dentition: prevalence and etiology. In: Drummond BK, Kilpatrick N, editors. Planning and care for children and adolescents with dental enamel defects: Springer; 2015. p. 15–30. This reference is one of many in this publication giving a good, current overview of MIH and its management. •• Anthonappa RP, King NM. Enamel defects in the permanent dentition: prevalence and etiology. In: Drummond BK, Kilpatrick N, editors. Planning and care for children and adolescents with dental enamel defects: Springer; 2015. p. 15–30. This reference is one of many in this publication giving a good, current overview of MIH and its management.
8.
go back to reference Leen AK. The interrelationship between molar hypomineralisation and orthodontics: Doctor of Clinical Dentistry Thesis. University of Melbourne, Melbourne Dental School; 2013. Leen AK. The interrelationship between molar hypomineralisation and orthodontics: Doctor of Clinical Dentistry Thesis. University of Melbourne, Melbourne Dental School; 2013.
9.
go back to reference Simmer J, Fincham A. Molecular mechanisms of dental enamel formation. Crit Rev Oral Biol Med. 1995;6(2):84–108.CrossRefPubMed Simmer J, Fincham A. Molecular mechanisms of dental enamel formation. Crit Rev Oral Biol Med. 1995;6(2):84–108.CrossRefPubMed
10.
go back to reference •• Silva MJ, Scurrah KJ, Craig JM, Manton DJ, Kilpatrick N. Etiology of molar incisor hypomineralization—a systematic review. Community Dent Oral Epidemiol. 2016;44(4):342–53. An expert review of current knowledge of the etiology of MIH. CrossRefPubMed •• Silva MJ, Scurrah KJ, Craig JM, Manton DJ, Kilpatrick N. Etiology of molar incisor hypomineralization—a systematic review. Community Dent Oral Epidemiol. 2016;44(4):342–53. An expert review of current knowledge of the etiology of MIH. CrossRefPubMed
11.
go back to reference Mangum J, Crombie F, Kilpatrick N, Manton D, Hubbard M. Surface integrity governs the proteome of hypomineralized enamel. J Dent Res. 2010;89(10):1160–5.CrossRefPubMed Mangum J, Crombie F, Kilpatrick N, Manton D, Hubbard M. Surface integrity governs the proteome of hypomineralized enamel. J Dent Res. 2010;89(10):1160–5.CrossRefPubMed
12.
13.
go back to reference Gutiérrez S, Torres D, Briceño I, Gómez AM, Baquero E. Clinical and molecular analysis of the enamelin gene ENAM in Colombian families with autosomal dominant amelogenesis imperfecta. Genet Mol Biol. 2012;35(3):557–66.CrossRefPubMedPubMedCentral Gutiérrez S, Torres D, Briceño I, Gómez AM, Baquero E. Clinical and molecular analysis of the enamelin gene ENAM in Colombian families with autosomal dominant amelogenesis imperfecta. Genet Mol Biol. 2012;35(3):557–66.CrossRefPubMedPubMedCentral
14.
go back to reference Chawla N, Messer L, Silva M. Clinical studies on molar-incisor-hypomineralisation part 1: distribution and putative associations. Eur Arch Paediatr Dent. 2008;9(4):180–90.CrossRefPubMed Chawla N, Messer L, Silva M. Clinical studies on molar-incisor-hypomineralisation part 1: distribution and putative associations. Eur Arch Paediatr Dent. 2008;9(4):180–90.CrossRefPubMed
15.
go back to reference Targino A, Rosenblatt A, Oliveira A, Chaves A, Santos V. The relationship of enamel defects and caries: a cohort study. Oral Dis. 2011;17(4):420–6.CrossRefPubMed Targino A, Rosenblatt A, Oliveira A, Chaves A, Santos V. The relationship of enamel defects and caries: a cohort study. Oral Dis. 2011;17(4):420–6.CrossRefPubMed
16.
go back to reference Mahoney EK, Morrison DG. Further examination of the prevalence of MIH in the Wellington region. N Z Dent J. 2011;107(3). Mahoney EK, Morrison DG. Further examination of the prevalence of MIH in the Wellington region. N Z Dent J. 2011;107(3).
17.
go back to reference Alaluusua S. Defining developmental enamel defect-associated childhood caries: where are we now? J Dent Res. 2012;91(6):525–7.CrossRefPubMed Alaluusua S. Defining developmental enamel defect-associated childhood caries: where are we now? J Dent Res. 2012;91(6):525–7.CrossRefPubMed
18.
go back to reference Jälevik B, Klingberg G. Dental treatment, dental fear and behaviour management problems in children with severe enamel hypomineralization of their permanent first molars. Int J Paediatr Dent. 2002;12(1):24–32.PubMed Jälevik B, Klingberg G. Dental treatment, dental fear and behaviour management problems in children with severe enamel hypomineralization of their permanent first molars. Int J Paediatr Dent. 2002;12(1):24–32.PubMed
19.
go back to reference Mejàre I, Bergman E, Grindefjord M. Hypomineralized molars and incisors of unknown origin: treatment outcome at age 18 years. Int J Paediatr Dent. 2005;15(1):20–8.CrossRefPubMed Mejàre I, Bergman E, Grindefjord M. Hypomineralized molars and incisors of unknown origin: treatment outcome at age 18 years. Int J Paediatr Dent. 2005;15(1):20–8.CrossRefPubMed
20.
go back to reference Kotsanos N, Kaklamanos E, Arapostathis K. Treatment management of first permanent molars in children with molar-incisor hypomineralisation. Eur J Paediatr Dent. 2005;6(4):179–84.PubMed Kotsanos N, Kaklamanos E, Arapostathis K. Treatment management of first permanent molars in children with molar-incisor hypomineralisation. Eur J Paediatr Dent. 2005;6(4):179–84.PubMed
21.
go back to reference Ong DV, Bleakley J. Compromised first permanent molars: an orthodontic perspective. Aust Dent J. 2010;55(1):2–14.CrossRefPubMed Ong DV, Bleakley J. Compromised first permanent molars: an orthodontic perspective. Aust Dent J. 2010;55(1):2–14.CrossRefPubMed
22.
go back to reference Normando ADC, Maia FA, da Silva Ursi WJ, Simone JL. Dentoalveolar changes after unilateral extractions of mandibular first molars and their influence on third molar development and position. World J Orthod. 2010;11(1):55–60. Normando ADC, Maia FA, da Silva Ursi WJ, Simone JL. Dentoalveolar changes after unilateral extractions of mandibular first molars and their influence on third molar development and position. World J Orthod. 2010;11(1):55–60.
23.
go back to reference Jälevik B, Möller M. Evaluation of spontaneous space closure and development of permanent dentition after extraction of hypomineralized permanent first molars. Int J Paediatr Dent. 2007;17(5):328–35.CrossRefPubMed Jälevik B, Möller M. Evaluation of spontaneous space closure and development of permanent dentition after extraction of hypomineralized permanent first molars. Int J Paediatr Dent. 2007;17(5):328–35.CrossRefPubMed
24.
go back to reference Deall SJ. Extraction of first permanent molars: A pilot study of actual and perceived effect on orthodontic treatment duration: Doctor of Clinical Dentistry Thesis. University of Melbourne, Melbourne Dental School; 2015. Deall SJ. Extraction of first permanent molars: A pilot study of actual and perceived effect on orthodontic treatment duration: Doctor of Clinical Dentistry Thesis. University of Melbourne, Melbourne Dental School; 2015.
25.
go back to reference Zhao Y. The efficacy of enamel sandblasting in bonding to hypomineralised teeth: Doctor of Clinical Dentistry Thesis. University of Melbourne, Melbourne Dental School; 2016. Zhao Y. The efficacy of enamel sandblasting in bonding to hypomineralised teeth: Doctor of Clinical Dentistry Thesis. University of Melbourne, Melbourne Dental School; 2016.
26.
go back to reference Cochrane NJ, Lo TW, Adams GG, Schneider PM. Quantitative analysis of enamel on debonded orthodontic brackets. Am J Orthod Dentofac Orthop. 2017;152(3):312–9.CrossRef Cochrane NJ, Lo TW, Adams GG, Schneider PM. Quantitative analysis of enamel on debonded orthodontic brackets. Am J Orthod Dentofac Orthop. 2017;152(3):312–9.CrossRef
Metadata
Title
Endemic Molar Incisor Hypomineralization: a Pandemic Problem That Requires Monitoring by the Entire Health Care Community
Authors
Paul M. Schneider
Margarita Silva
Publication date
01-06-2018
Publisher
Springer US
Published in
Current Osteoporosis Reports / Issue 3/2018
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-018-0444-x

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