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Current Osteoporosis Reports

Published in:

01-06-2018 | Pediatrics (L Ward and E Imel, Section Editors)

Anabolic Therapy for the Treatment of Osteoporosis in Childhood

Authors: Leanne M. Ward, Frank Rauch

Published in: Current Osteoporosis Reports | Issue 3/2018

Abstract

Purpose of Review

Numerous forms of osteoporosis in childhood are characterized by low bone turnover (for example, osteoporosis due to neuromuscular disorders and glucocorticoid exposure). Anti-resorptive therapy, traditionally used to treat osteoporosis in the young, is associated with further reductions in bone turnover, raising concerns about the long-term safety and efficacy of such therapy. These observations have led to increasing interest in the role of anabolic therapy to treat pediatric osteoporosis.

Recent Findings

While growth hormone and androgens appears to be relatively weak anabolic modulators of bone mass, emerging therapies targeting bone formation pathways (anti-transforming growth factor beta antibody and anti-sclerostin antibody) hold considerable promise. Teriparatide remains an attractive option that merits formal study for patients post-epiphyseal fusion, although it must be considered that adult studies have shown its effect is blunted when administered following bisphosphonate therapy. Mechanical stimulation of bone through whole body vibration therapy appears to be much less effective than bisphosphonate therapy for treating osteoporosis in children.

Summary

New anabolic therapies which target important pathways in skeletal metabolism merit further study in children, including their effects on fracture risk reduction and after treatment discontinuation.

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Title: Anabolic Therapy for the Treatment of Osteoporosis in Childhood
Authors: Leanne M. Ward
Frank Rauch
Publication date: 01-06-2018
Publisher: Springer US
Published in: Current Osteoporosis Reports / Issue 3/2018
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-018-0434-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Anabolic Therapy for the Treatment of Osteoporosis in Childhood

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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