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Open Access 01-12-2017 | Osteocytes (T Bellido and J Klein-Nulend, Section Editors)

Diet and Exercise: a Match Made in Bone

Authors: Hubertine M.E. Willems, Ellen G.H.M. van den Heuvel, Ruud J.W. Schoemaker, Jenneke Klein-Nulend, Astrid D. Bakker

Published in: Current Osteoporosis Reports | Issue 6/2017

Abstract

Purpose of Review

Multiple dietary components have the potential to positively affect bone mineral density in early life and reduce loss of bone mass with aging. In addition, regular weight-bearing physical activity has a strong positive effect on bone through activation of osteocyte signaling. We will explore possible synergistic effects of dietary components and mechanical stimuli for bone health by identifying dietary components that have the potential to alter the response of osteocytes to mechanical loading.

Recent Findings

Several (sub)cellular aspects of osteocytes determine their signaling towards osteoblasts and osteoclasts in response to mechanical stimuli, such as the osteocyte cytoskeleton, estrogen receptor α, the vitamin D receptor, and the architecture of the lacunocanalicular system. Potential modulators of these features include 1,25-dihydroxy vitamin D₃, several forms of vitamin K, and the phytoestrogen genistein.

Summary

Multiple dietary components potentially affect osteocyte function and therefore may have a synergistic effect on bone health when combined with a regime of physical activity.

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Title: Diet and Exercise: a Match Made in Bone
Authors: Hubertine M.E. Willems
Ellen G.H.M. van den Heuvel
Ruud J.W. Schoemaker
Jenneke Klein-Nulend
Astrid D. Bakker
Publication date: 01-12-2017
Publisher: Springer US
Published in: Current Osteoporosis Reports / Issue 6/2017
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-017-0406-8

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Diet and Exercise: a Match Made in Bone

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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