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Current Osteoporosis Reports
Published in: Current Osteoporosis Reports 4/2017

01-08-2017 | Osteoimmunology (MB Humphrey and M Nakamura, Section Editors)

Osteomacs and Bone Regeneration

Authors: Lena Batoon, Susan Marie Millard, Liza Jane Raggatt, Allison Robyn Pettit

Published in: Current Osteoporosis Reports | Issue 4/2017

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Abstract

Purpose of Review

Mounting evidence supporting the critical contribution of macrophages, in particular osteal macrophages, to bone regeneration is reviewed. We specifically examine the potential role of macrophages in the basic multicellular units coordinating lifelong bone regeneration via remodelling and bone regeneration in response to injury. We review and discuss the distinctions between macrophage and osteoclast contributions to bone homeostasis, particularly the dichotomous role of the colony-stimulating factor 1—colony-stimulating factor 1 receptor axis.

Recent Findings

The impact of inflammation associated with aging and other hallmarks of aging, including senescence, on macrophage function is addressed in the context of osteoporosis and delayed fracture repair. Resident macrophages versus recruited macrophage contributions to fracture healing are also discussed.

Summary

We identify some of the remaining knowledge gaps that will need to be closed in order to maximise benefits from therapeutically modulating or mimicking the function of macrophages to improve bone health and regeneration over a lifetime.
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Metadata
Title
Osteomacs and Bone Regeneration
Authors
Lena Batoon
Susan Marie Millard
Liza Jane Raggatt
Allison Robyn Pettit
Publication date
01-08-2017
Publisher
Springer US
Published in
Current Osteoporosis Reports / Issue 4/2017
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-017-0384-x

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