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Published in: Current Osteoporosis Reports 1/2013

01-03-2013 | Current Therapeutics (SL Silverman, Section Editor)

Adherence with Medications Used to Treat Osteoporosis: Behavioral Insights

Author: John T. Schousboe

Published in: Current Osteoporosis Reports | Issue 1/2013

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Abstract

Non-persistence (never starting or stopping medication prematurely) and non-compliance (taking medication inappropriately) with fracture prevention medication among those at high risk of fracture remain significant barriers to optimal reduction of osteoporotic fractures. Current research suggest that for patients to persist and comply with prescriptions for fracture prevention medication, they need to believe that they are at significant risk of fracture, that the prescribed medication can safely reduce their risk of fracture without exposing them to long-term harm, that equally effective non-medicinal therapies are not available, and that they can successfully execute medication use in the context of their daily task demands. Further research is needed to understand; a) the mental models of osteoporosis, fractures, and medications used to treat osteoporosis that patients employ when making decisions as to whether or not to take fracture prevention medication; and b) how patients arbitrage information from various sources (health care providers, family, friends, and other sources) to formulate their beliefs about osteoporosis and medications used to treat it.
Literature
1.
go back to reference • Yeaw J, Benner JS, Walt JG, Sian S, Smith DB. Comparing adherence and persistence across 6 chronic medication classes. J Manag Care Pharm. 2009;15(9):728–40. This descriptive study shows how medication use behavior to prevent futrue adverse health events is similar across numerous medications and target diseases. • Yeaw J, Benner JS, Walt JG, Sian S, Smith DB. Comparing adherence and persistence across 6 chronic medication classes. J Manag Care Pharm. 2009;15(9):728–40. This descriptive study shows how medication use behavior to prevent futrue adverse health events is similar across numerous medications and target diseases.
2.
go back to reference World Health Organization. Adherence to long-term therapies: Evidence for action 2003. 2003. World Health Organization. Adherence to long-term therapies: Evidence for action 2003. 2003.
3.
go back to reference Cramer JA, Roy A, Burrell A, Fairchild CJ, Fuldeore MJ, Ollendorf DA, et al. Medication compliance and persistence: terminology and definitions. Value Health. 2008;11(1):44–7.PubMedCrossRef Cramer JA, Roy A, Burrell A, Fairchild CJ, Fuldeore MJ, Ollendorf DA, et al. Medication compliance and persistence: terminology and definitions. Value Health. 2008;11(1):44–7.PubMedCrossRef
4.
go back to reference Shah NR, Hirsch AG, Zacker C, Taylor S, Wood GC, Stewart WF. Factors associated with first-fill adherence rates for diabetic medications: a cohort study. J Gen Intern Med. 2009;24(2):233–7.PubMedCrossRef Shah NR, Hirsch AG, Zacker C, Taylor S, Wood GC, Stewart WF. Factors associated with first-fill adherence rates for diabetic medications: a cohort study. J Gen Intern Med. 2009;24(2):233–7.PubMedCrossRef
5.
go back to reference Shah NR, Hirsch AG, Zacker C, Wood GC, Schoenthaler A, Ogedegbe G, et al. Predictors of firstfill adherence for patients with hypertension. Am J Hypertens. 2009;22(4):392–6.PubMedCrossRef Shah NR, Hirsch AG, Zacker C, Wood GC, Schoenthaler A, Ogedegbe G, et al. Predictors of firstfill adherence for patients with hypertension. Am J Hypertens. 2009;22(4):392–6.PubMedCrossRef
6.
go back to reference • Fischer MA, Stedman MR, Lii J, Vogeli C, Shrank WH, Brookhart MA, et al. Primary medication non-adherence: analysis of 195,930 electronic prescriptions. J Gen Intern Med. 2010;25(4):284–90. This important study is the largest of the few showing the extent and importance of primary non-adherence to a variety of medications.PubMedCrossRef • Fischer MA, Stedman MR, Lii J, Vogeli C, Shrank WH, Brookhart MA, et al. Primary medication non-adherence: analysis of 195,930 electronic prescriptions. J Gen Intern Med. 2010;25(4):284–90. This important study is the largest of the few showing the extent and importance of primary non-adherence to a variety of medications.PubMedCrossRef
7.
go back to reference Kothawala P, Badamgarav E, Ryu S, Miller RM, Halbert RJ. Systematic review and meta-analysis of real-world adherence to drug therapy for osteoporosis. Mayo Clin Proc. 2007;82(12):1493–501.PubMedCrossRef Kothawala P, Badamgarav E, Ryu S, Miller RM, Halbert RJ. Systematic review and meta-analysis of real-world adherence to drug therapy for osteoporosis. Mayo Clin Proc. 2007;82(12):1493–501.PubMedCrossRef
8.
go back to reference Burden AM, Paterson JM, Solomon DH, Mamdani M, Juurlink DN, Cadarette SM. Bisphosphonate prescribing, persistence and cumulative exposure in Ontario, Canada. Osteoporos Int. 2012;23(3):1075–82.PubMedCrossRef Burden AM, Paterson JM, Solomon DH, Mamdani M, Juurlink DN, Cadarette SM. Bisphosphonate prescribing, persistence and cumulative exposure in Ontario, Canada. Osteoporos Int. 2012;23(3):1075–82.PubMedCrossRef
9.
go back to reference Recker RR, Gallagher R, MacCosbe PE. Effect of dosing frequency on bisphosphonate medication adherence in a large longitudinal cohort of women. Mayo Clin Proc. 2005;80(7):856–61. Recker RR, Gallagher R, MacCosbe PE. Effect of dosing frequency on bisphosphonate medication adherence in a large longitudinal cohort of women. Mayo Clin Proc. 2005;80(7):856–61.
10.
go back to reference Ettinger MP, Gallagher R, MacCosbe PE. Medication persistence with weekly versus daily doses of orally administered bisphosphonates. Endocr Pract. 2006;12(5):522–8.PubMed Ettinger MP, Gallagher R, MacCosbe PE. Medication persistence with weekly versus daily doses of orally administered bisphosphonates. Endocr Pract. 2006;12(5):522–8.PubMed
11.
go back to reference Weiss TW, Henderson SC, McHorney CA, Cramer JA. Persistence across weekly and monthly bisphosphonates: analysis of US retail pharmacy prescription refills. Curr Med Res Opin. 2007;23(9):2193–203.PubMedCrossRef Weiss TW, Henderson SC, McHorney CA, Cramer JA. Persistence across weekly and monthly bisphosphonates: analysis of US retail pharmacy prescription refills. Curr Med Res Opin. 2007;23(9):2193–203.PubMedCrossRef
12.
go back to reference Rossini M, Viapiana O, Gatti D, Adami S. Once-monthly oral ibandronate in postmenopausal osteoporosis: translation and updated review. Clin Ther. 2009;31(7):1497–510.PubMedCrossRef Rossini M, Viapiana O, Gatti D, Adami S. Once-monthly oral ibandronate in postmenopausal osteoporosis: translation and updated review. Clin Ther. 2009;31(7):1497–510.PubMedCrossRef
13.
go back to reference Hadji P, Ziller V, Gamerdinger D, Spieler W, Articus K, Baier M, et al. Quality of life and health status with zoledronic acid and generic alendronate–a secondary analysis of the Rapid Onset and Sustained Efficacy (ROSE) study in postmenopausal women with low bone mass. Osteoporos Int. 2012;23(7):2043–51.PubMedCrossRef Hadji P, Ziller V, Gamerdinger D, Spieler W, Articus K, Baier M, et al. Quality of life and health status with zoledronic acid and generic alendronate–a secondary analysis of the Rapid Onset and Sustained Efficacy (ROSE) study in postmenopausal women with low bone mass. Osteoporos Int. 2012;23(7):2043–51.PubMedCrossRef
14.
go back to reference Lee Y-K, Nho J-H, Ha Y-C, Koo K-H. Persistence with intravenous zoledronate in elderly patients with osteoporosis. Osteoporos Int. 2012;23(9):2329–33.PubMedCrossRef Lee Y-K, Nho J-H, Ha Y-C, Koo K-H. Persistence with intravenous zoledronate in elderly patients with osteoporosis. Osteoporos Int. 2012;23(9):2329–33.PubMedCrossRef
15.
go back to reference Solomon DH, Avorn J, Katz JN, Finkelstein JS, Arnold M, Polinski JM, et al. Compliance with osteoporosis medications. Arch Intern Med. 2005;165(20):2414–9.PubMedCrossRef Solomon DH, Avorn J, Katz JN, Finkelstein JS, Arnold M, Polinski JM, et al. Compliance with osteoporosis medications. Arch Intern Med. 2005;165(20):2414–9.PubMedCrossRef
16.
go back to reference Lo JC, Pressman AR, Omar MA, Ettinger B. Persistence with weekly alendronate therapy among postmenopausal women. Osteoporos Int. 2006;17(6):922–8.PubMedCrossRef Lo JC, Pressman AR, Omar MA, Ettinger B. Persistence with weekly alendronate therapy among postmenopausal women. Osteoporos Int. 2006;17(6):922–8.PubMedCrossRef
17.
go back to reference Downey TW, Foltz SH, Boccuzzi SJ, Omar MA, Kahler KH. Adherence and persistence associated with the pharmacologic treatment of osteoporosis in a managed care setting. South Med J. 2006;99(6):570–5.PubMedCrossRef Downey TW, Foltz SH, Boccuzzi SJ, Omar MA, Kahler KH. Adherence and persistence associated with the pharmacologic treatment of osteoporosis in a managed care setting. South Med J. 2006;99(6):570–5.PubMedCrossRef
18.
go back to reference Carr AJ, Thompson PW, Cooper C. Factors associated with adherence and persistence to bisphosphonate therapy in osteoporosis: a cross-sectional survey. Osteoporos Int. 2006;17(11):1638–44.PubMedCrossRef Carr AJ, Thompson PW, Cooper C. Factors associated with adherence and persistence to bisphosphonate therapy in osteoporosis: a cross-sectional survey. Osteoporos Int. 2006;17(11):1638–44.PubMedCrossRef
19.•
go back to reference Landfeldt E, Strom O, Robbins S, Borgstrom F. Adherence to treatment of primary osteoporosis and its association to fractures–the Swedish Adherence Register Analysis (SARA). Osteoporos Int. 2012;23(2):433–43. An important study showing the temporal relationship between non-persistence with fracture prevention medications and incident fractures, using a comprehensive national database.PubMedCrossRef Landfeldt E, Strom O, Robbins S, Borgstrom F. Adherence to treatment of primary osteoporosis and its association to fractures–the Swedish Adherence Register Analysis (SARA). Osteoporos Int. 2012;23(2):433–43. An important study showing the temporal relationship between non-persistence with fracture prevention medications and incident fractures, using a comprehensive national database.PubMedCrossRef
20.
go back to reference Devine J, Trice S, Finney Z, Yarger S, Nwokeji E, Linton A, et al. A retrospective analysis of extended-interval dosing and the impact on bisphosphonate compliance in the US Military Health System. Osteoporos Int. 2012;23(4):1415–24.PubMedCrossRef Devine J, Trice S, Finney Z, Yarger S, Nwokeji E, Linton A, et al. A retrospective analysis of extended-interval dosing and the impact on bisphosphonate compliance in the US Military Health System. Osteoporos Int. 2012;23(4):1415–24.PubMedCrossRef
21.
go back to reference Wamala S, Merlo J, Bostrom G, Hogstedt C, Agren G. Socioeconomic disadvantage and primary non-adherence with medication in Sweden. Int J Qual Health Care. 2007;19(3):134–40.PubMedCrossRef Wamala S, Merlo J, Bostrom G, Hogstedt C, Agren G. Socioeconomic disadvantage and primary non-adherence with medication in Sweden. Int J Qual Health Care. 2007;19(3):134–40.PubMedCrossRef
22.
go back to reference Papaioannou A, Ioannidis G, Adachi JD, Sebaldt RJ, Ferko N, Puglia M, et al. Adherence to bisphosphonates and hormone replacement therapy in a tertiary care setting of patients in the CANDOO database. Osteoporos Int. 2003;14(10):808–13.PubMedCrossRef Papaioannou A, Ioannidis G, Adachi JD, Sebaldt RJ, Ferko N, Puglia M, et al. Adherence to bisphosphonates and hormone replacement therapy in a tertiary care setting of patients in the CANDOO database. Osteoporos Int. 2003;14(10):808–13.PubMedCrossRef
23.
go back to reference McCombs JS, Thiebaud P, McLaughlin-Miley C, Shi J. Compliance with drug therapies for the treatment and prevention of osteoporosis. Maturitas. 2004;48(3):271–87.PubMedCrossRef McCombs JS, Thiebaud P, McLaughlin-Miley C, Shi J. Compliance with drug therapies for the treatment and prevention of osteoporosis. Maturitas. 2004;48(3):271–87.PubMedCrossRef
24.
go back to reference Zambon A, Baio G, Mazzaglia G, Merlino L, Corrao G. Discontinuity and failures of therapy with bisphosphonates: joint assessment of predictors with multi-state models. Pharmacoepidemiol Drug Saf. 2008;17(3):260–9.PubMedCrossRef Zambon A, Baio G, Mazzaglia G, Merlino L, Corrao G. Discontinuity and failures of therapy with bisphosphonates: joint assessment of predictors with multi-state models. Pharmacoepidemiol Drug Saf. 2008;17(3):260–9.PubMedCrossRef
25.
go back to reference Pressman A, Forsyth B, Ettinger B, Tosteson AN. Initiation of osteoporosis treatment after bone mineral density testing. Osteoporos Int. 2001;12(5):337–42.PubMedCrossRef Pressman A, Forsyth B, Ettinger B, Tosteson AN. Initiation of osteoporosis treatment after bone mineral density testing. Osteoporos Int. 2001;12(5):337–42.PubMedCrossRef
26.
go back to reference Solomon DH, Levin E, Helfgott SM. Patterns of medication use before and after bone densitometry: factors associated with appropriate treatment. J Rheumatol. 2000;27(6):1496–500.PubMed Solomon DH, Levin E, Helfgott SM. Patterns of medication use before and after bone densitometry: factors associated with appropriate treatment. J Rheumatol. 2000;27(6):1496–500.PubMed
27.
go back to reference Rubin SM, Cummings SR. Results of bone densitometry affect women's decisions about taking measures to prevent fractures. Ann Intern Med. 1992;116(12 Pt 1):990–5.PubMed Rubin SM, Cummings SR. Results of bone densitometry affect women's decisions about taking measures to prevent fractures. Ann Intern Med. 1992;116(12 Pt 1):990–5.PubMed
28.
go back to reference Silverman SL, Greenwald M, Klein RA, Drinkwater BL. Effect of bone density information on decisions about hormone replacement therapy: a randomized trial. Obstet Gynecol. 1997;89(3):321–5.PubMedCrossRef Silverman SL, Greenwald M, Klein RA, Drinkwater BL. Effect of bone density information on decisions about hormone replacement therapy: a randomized trial. Obstet Gynecol. 1997;89(3):321–5.PubMedCrossRef
29.
go back to reference Pickney CS, Arnason JA. Correlation between patient recall of bone densitometry results and subsequent treatment adherence. Osteoporos Int. 2005;16(9):1156–60.PubMedCrossRef Pickney CS, Arnason JA. Correlation between patient recall of bone densitometry results and subsequent treatment adherence. Osteoporos Int. 2005;16(9):1156–60.PubMedCrossRef
30.
go back to reference Berecki-Gisolf J, Hockey R, Dobson A. Adherence to bisphosphonate treatment by elderly women. Menopause. 2008;15(5):984–90.PubMedCrossRef Berecki-Gisolf J, Hockey R, Dobson A. Adherence to bisphosphonate treatment by elderly women. Menopause. 2008;15(5):984–90.PubMedCrossRef
31.
go back to reference Penning-van Beest FJ, Erkens JA, Olson M, Herings RM. Determinants of non-compliance with bisphosphonates in women with postmenopausal osteoporosis. Curr Med Res Opin. 2008;24(5):1337–44.PubMedCrossRef Penning-van Beest FJ, Erkens JA, Olson M, Herings RM. Determinants of non-compliance with bisphosphonates in women with postmenopausal osteoporosis. Curr Med Res Opin. 2008;24(5):1337–44.PubMedCrossRef
32.
go back to reference Gould ON, McDonald-Miszcak L, King B. Metacognition and medication adherence: how do older adults remember? Exp Aging Res. 1997;23:315–42.PubMedCrossRef Gould ON, McDonald-Miszcak L, King B. Metacognition and medication adherence: how do older adults remember? Exp Aging Res. 1997;23:315–42.PubMedCrossRef
33.
go back to reference Rosen MI, Beauvais JE, Rigsby MO, Salahi JT, Ryan CE, Cramer JA. Neuropsychological correlates of suboptimal adherence to metformin. J Behav Med. 2003;26(4):349–60.PubMedCrossRef Rosen MI, Beauvais JE, Rigsby MO, Salahi JT, Ryan CE, Cramer JA. Neuropsychological correlates of suboptimal adherence to metformin. J Behav Med. 2003;26(4):349–60.PubMedCrossRef
34.
go back to reference Gray SL, Mahoney JE, Blough DK. Medication adherence in elderly patients receiving home health services following hospital discharge. Ann Pharmacother. 2001;35(5):539–45.PubMedCrossRef Gray SL, Mahoney JE, Blough DK. Medication adherence in elderly patients receiving home health services following hospital discharge. Ann Pharmacother. 2001;35(5):539–45.PubMedCrossRef
35.
go back to reference Salas M, In't Veld BA, van der Linden PD, Hofman A, Breteler M, Stricker BH. Impaired cognitive function and compliance with antihypertensive drugs in elderly: the Rotterdam Study. Clin Pharmacol Ther. 2001;70(6):561–6.PubMedCrossRef Salas M, In't Veld BA, van der Linden PD, Hofman A, Breteler M, Stricker BH. Impaired cognitive function and compliance with antihypertensive drugs in elderly: the Rotterdam Study. Clin Pharmacol Ther. 2001;70(6):561–6.PubMedCrossRef
36.
go back to reference Kiortsis DN, Giral P, Bruckert E, Turpin G. Factors associated with low compliance with lipidlowering drugs in hyperlipidemic patients. J Clin Pharm Ther. 2000;25(6):445–51.PubMedCrossRef Kiortsis DN, Giral P, Bruckert E, Turpin G. Factors associated with low compliance with lipidlowering drugs in hyperlipidemic patients. J Clin Pharm Ther. 2000;25(6):445–51.PubMedCrossRef
37.
go back to reference Ross S, Samuels E, Gairy K, Iqbal S, Badamgarav E, Siris E. A meta-analysis of osteoporotic fracture risk with medication nonadherence. Value Health. 2011;14(4):571–81.PubMedCrossRef Ross S, Samuels E, Gairy K, Iqbal S, Badamgarav E, Siris E. A meta-analysis of osteoporotic fracture risk with medication nonadherence. Value Health. 2011;14(4):571–81.PubMedCrossRef
38.
go back to reference Siris ES, Harris ST, Rosen CJ, Barr CE, Arvesen JN, Abbott TA, et al. Adherence to bisphosphonate therapy and fracture rates in osteoporotic women: relationship to vertebral and nonvertebral fractures from 2 US claims databases. Mayo Clin Proc. 2006;81(8):1013–22.PubMedCrossRef Siris ES, Harris ST, Rosen CJ, Barr CE, Arvesen JN, Abbott TA, et al. Adherence to bisphosphonate therapy and fracture rates in osteoporotic women: relationship to vertebral and nonvertebral fractures from 2 US claims databases. Mayo Clin Proc. 2006;81(8):1013–22.PubMedCrossRef
39.
go back to reference • Patrick AR, Brookhart MA, Losina E, Schousboe JT, Cadarette SM, Mogun H, et al. The complex relation between bisphosphonate adherence and fracture reduction. J Clin Endocrinol Metab. 2010;95(7):3251–9. The most detailed study to date exploring the details of the relationship between level and adherence to fracture prevention medication and incident fractures. • Patrick AR, Brookhart MA, Losina E, Schousboe JT, Cadarette SM, Mogun H, et al. The complex relation between bisphosphonate adherence and fracture reduction. J Clin Endocrinol Metab. 2010;95(7):3251–9. The most detailed study to date exploring the details of the relationship between level and adherence to fracture prevention medication and incident fractures.
40.
go back to reference Rabenda V, Mertens R, Fabri V, Vanoverloop J, Sumkay F, Vannecke C, et al. Adherence to bisphosphonates therapy and hip fracture risk in osteoporotic women. Osteoporos Int. 2008;19(6):811–8.PubMedCrossRef Rabenda V, Mertens R, Fabri V, Vanoverloop J, Sumkay F, Vannecke C, et al. Adherence to bisphosphonates therapy and hip fracture risk in osteoporotic women. Osteoporos Int. 2008;19(6):811–8.PubMedCrossRef
41.
go back to reference Sheehy O, Kindundu C, Barbeau M, LeLorier J. Adherence to weekly oral bisphosphonate therapy: cost of wasted drugs and fractures. Osteoporos Int. 2009;20(9):1583–94.PubMedCrossRef Sheehy O, Kindundu C, Barbeau M, LeLorier J. Adherence to weekly oral bisphosphonate therapy: cost of wasted drugs and fractures. Osteoporos Int. 2009;20(9):1583–94.PubMedCrossRef
42.
go back to reference Halpern R, Becker L, Iqbal SU, Kazis LE, Macarios D, Badamgarav E. The association of adherence to osteoporosis therapies with fracture, all-cause medical costs, and all-cause hospitalizations: a retrospective claims analysis of female health plan enrollees with osteoporosis. J Manag Care Pharm. 2011;17(1):25–39.PubMed Halpern R, Becker L, Iqbal SU, Kazis LE, Macarios D, Badamgarav E. The association of adherence to osteoporosis therapies with fracture, all-cause medical costs, and all-cause hospitalizations: a retrospective claims analysis of female health plan enrollees with osteoporosis. J Manag Care Pharm. 2011;17(1):25–39.PubMed
43.
go back to reference Sunyecz JA, Mucha L, Baser O, Barr CE, Amonkar MM. Impact of compliance and persistence with bisphosphonate therapy on health care costs and utilization. Osteoporos Int. 2008;19(10):1421–9.PubMedCrossRef Sunyecz JA, Mucha L, Baser O, Barr CE, Amonkar MM. Impact of compliance and persistence with bisphosphonate therapy on health care costs and utilization. Osteoporos Int. 2008;19(10):1421–9.PubMedCrossRef
44.
go back to reference Cadarette SM, Solomon DH, Katz JN, Patrick AR, Brookhart MA. Adherence to osteoporosis drugs and fracture prevention: no evidence of healthy adherer bias in a frail cohort of seniors. Osteoporos Int. 2011;22(3):943–54.PubMedCrossRef Cadarette SM, Solomon DH, Katz JN, Patrick AR, Brookhart MA. Adherence to osteoporosis drugs and fracture prevention: no evidence of healthy adherer bias in a frail cohort of seniors. Osteoporos Int. 2011;22(3):943–54.PubMedCrossRef
45.
go back to reference Curtis JR, Larson JC, Delzell E, Brookhart MA, Cadarette SM, Chlebowski R, et al. Placebo adherence, clinical outcomes, and mortality in the women's health initiative randomized hormone therapy trials. Med Care. 2011;49(5):427–35.PubMedCrossRef Curtis JR, Larson JC, Delzell E, Brookhart MA, Cadarette SM, Chlebowski R, et al. Placebo adherence, clinical outcomes, and mortality in the women's health initiative randomized hormone therapy trials. Med Care. 2011;49(5):427–35.PubMedCrossRef
46.
go back to reference Curtis JR, Delzell E, Chen L, Black D, Ensrud K, Judd S, et al. The relationship between bisphosphonate adherence and fracture: is it the behavior or the medication? Results from the placebo arm of the fracture intervention trial. J Bone Miner Res. 2011;26(4):683–8.PubMedCrossRef Curtis JR, Delzell E, Chen L, Black D, Ensrud K, Judd S, et al. The relationship between bisphosphonate adherence and fracture: is it the behavior or the medication? Results from the placebo arm of the fracture intervention trial. J Bone Miner Res. 2011;26(4):683–8.PubMedCrossRef
47.
go back to reference Tosteson AN, Grove MR, Hammond CS, Moncur MM, Ray GT, Hebert GM, et al. Early discontinuation of treatment for osteoporosis. Am J Med. 2003;115(3):209–16.PubMedCrossRef Tosteson AN, Grove MR, Hammond CS, Moncur MM, Ray GT, Hebert GM, et al. Early discontinuation of treatment for osteoporosis. Am J Med. 2003;115(3):209–16.PubMedCrossRef
48.
go back to reference Hamilton B, McCoy K, Taggart H. Tolerability and compliance with risedronate in clinical practice. Osteoporos Int. 2003;14(3):259–62.PubMed Hamilton B, McCoy K, Taggart H. Tolerability and compliance with risedronate in clinical practice. Osteoporos Int. 2003;14(3):259–62.PubMed
49.
go back to reference Rossini M, Bianchi G, Di Munno O, Giannini S, Minisola S, Sinigaglia L, et al. Determinants of adherence to osteoporosis treatment in clinical practice. Osteoporos Int. 2006;17(6):914–21.PubMedCrossRef Rossini M, Bianchi G, Di Munno O, Giannini S, Minisola S, Sinigaglia L, et al. Determinants of adherence to osteoporosis treatment in clinical practice. Osteoporos Int. 2006;17(6):914–21.PubMedCrossRef
50.
go back to reference Britten N, Ukoumunne OC, Boulton MG. Patients' attitudes to medicines and expectations for prescriptions. Health Expect. 2002;5(3):256–69.PubMedCrossRef Britten N, Ukoumunne OC, Boulton MG. Patients' attitudes to medicines and expectations for prescriptions. Health Expect. 2002;5(3):256–69.PubMedCrossRef
51.
go back to reference Unson CG, Siccion E, Gaztambide J, Gaztambide S, Mahoney Trella P, Prestwood K. Nonadherence and osteoporosis treatment preferences of older women: a qualitative study. J Womens Health (Larchmt). 2003;12(10):1037–45.CrossRef Unson CG, Siccion E, Gaztambide J, Gaztambide S, Mahoney Trella P, Prestwood K. Nonadherence and osteoporosis treatment preferences of older women: a qualitative study. J Womens Health (Larchmt). 2003;12(10):1037–45.CrossRef
52.
go back to reference Britten N. Patients' ideas about medicines: a qualitative study in a general practice population. Br J Gen Pract. 1994;44(387):465–8.PubMed Britten N. Patients' ideas about medicines: a qualitative study in a general practice population. Br J Gen Pract. 1994;44(387):465–8.PubMed
53.
go back to reference Lin EH, Von Korff M, Ludman EJ, Rutter C, Bush TM, Simon GE, et al. Enhancing adherence to prevent depression relapse in primary care. Gen Hosp Psychiatry. 2003;25(5):303–10.PubMedCrossRef Lin EH, Von Korff M, Ludman EJ, Rutter C, Bush TM, Simon GE, et al. Enhancing adherence to prevent depression relapse in primary care. Gen Hosp Psychiatry. 2003;25(5):303–10.PubMedCrossRef
54.
go back to reference Benson J, Britten N. Patients' decisions about whether or not to take antihypertensive drugs: qualitative study. BMJ. 2002;325(7369):873.PubMedCrossRef Benson J, Britten N. Patients' decisions about whether or not to take antihypertensive drugs: qualitative study. BMJ. 2002;325(7369):873.PubMedCrossRef
55.
go back to reference Horne R, Weinman J, Hankins M. The Beliefs about Medications Questionnaire: the development of a new method for assessing the cognitive representation about medication. Psychol Health. 1999;14:1–24.CrossRef Horne R, Weinman J, Hankins M. The Beliefs about Medications Questionnaire: the development of a new method for assessing the cognitive representation about medication. Psychol Health. 1999;14:1–24.CrossRef
56.
go back to reference Donovan JL, Blake DR. Patient non-compliance: deviance or reasoned decision-making? Soc Sci Med. 1992;34(5):507–13.PubMedCrossRef Donovan JL, Blake DR. Patient non-compliance: deviance or reasoned decision-making? Soc Sci Med. 1992;34(5):507–13.PubMedCrossRef
57.
58.
go back to reference Shoemaker SJ, de Oliveira DR, Alves M, Ekstrand M. The medication experience: Preliminary evidence of its value for patient education and counseling on chronic medications. Patient Educ Couns. 2011;83(3):443–50.PubMedCrossRef Shoemaker SJ, de Oliveira DR, Alves M, Ekstrand M. The medication experience: Preliminary evidence of its value for patient education and counseling on chronic medications. Patient Educ Couns. 2011;83(3):443–50.PubMedCrossRef
59.
go back to reference Adams S, Pill R, Jones A. Medication, chronic illness and identity: the perspective of people with asthma. Soc Sci Med. 1997;45(2):189–201.PubMedCrossRef Adams S, Pill R, Jones A. Medication, chronic illness and identity: the perspective of people with asthma. Soc Sci Med. 1997;45(2):189–201.PubMedCrossRef
60.
go back to reference Dowell J, Hudson H. A qualitative study of medication-taking behaviour in primary care. Fam Pract. 1997;14(5):369–75.PubMedCrossRef Dowell J, Hudson H. A qualitative study of medication-taking behaviour in primary care. Fam Pract. 1997;14(5):369–75.PubMedCrossRef
61.
go back to reference • Sale JEM, Gignac MA, Hawker G, Frankel L, Beaton D, Bogoch E, et al. Decision to take osteoporosis medication in patients who have had a fracture and are 'high' risk for future fracture: a qualitative study. BMC Musculoskelet Disord. 2011;12:92. An important detailed descriptive study of how patients decide whether or not to accept a recommended prescription for fracture prevention medication.PubMedCrossRef • Sale JEM, Gignac MA, Hawker G, Frankel L, Beaton D, Bogoch E, et al. Decision to take osteoporosis medication in patients who have had a fracture and are 'high' risk for future fracture: a qualitative study. BMC Musculoskelet Disord. 2011;12:92. An important detailed descriptive study of how patients decide whether or not to accept a recommended prescription for fracture prevention medication.PubMedCrossRef
62.
go back to reference Janz N, Becker M. The health belief model: a decade later. Heal Educ Q. 1984;11(1):1–47.CrossRef Janz N, Becker M. The health belief model: a decade later. Heal Educ Q. 1984;11(1):1–47.CrossRef
63.
go back to reference Connor M, Sparks P. The theory of planned behavior and health behaviors. In: Connor M, Norman P, editors. Predicting health behavior. Philadelphia: Open University Press; 1995. p. 121–62. Connor M, Sparks P. The theory of planned behavior and health behaviors. In: Connor M, Norman P, editors. Predicting health behavior. Philadelphia: Open University Press; 1995. p. 121–62.
64.
go back to reference Leventhal H, Diefenbach M, Leventhal EA. Illness cognition: using common sense to understand treatment adherence and affect cognitive interactions. Cogn Ther Res. 1992;16(2):143–63.CrossRef Leventhal H, Diefenbach M, Leventhal EA. Illness cognition: using common sense to understand treatment adherence and affect cognitive interactions. Cogn Ther Res. 1992;16(2):143–63.CrossRef
65.
go back to reference Bandura A. Social foundations of thought and action. A social cognitive theory. Englewood Cliffs: Prentice-Hall, Inc.; 1986. Bandura A. Social foundations of thought and action. A social cognitive theory. Englewood Cliffs: Prentice-Hall, Inc.; 1986.
66.
go back to reference Buglar ME, White KM, Robinson NG. The role of self-efficacy in dental patients' brushing and flossing: testing an extended Health Belief Model. Patient Educ Couns. 2010;78(2):269–72.PubMedCrossRef Buglar ME, White KM, Robinson NG. The role of self-efficacy in dental patients' brushing and flossing: testing an extended Health Belief Model. Patient Educ Couns. 2010;78(2):269–72.PubMedCrossRef
67.
go back to reference Bylund CL, Galvin KM, Dunet DO, Reyes M. Using the extended health belief model to understand siblings' perceptions of risk for hereditary hemochromatosis. Patient Educ Couns. 2011;82(1):36–41.PubMedCrossRef Bylund CL, Galvin KM, Dunet DO, Reyes M. Using the extended health belief model to understand siblings' perceptions of risk for hereditary hemochromatosis. Patient Educ Couns. 2011;82(1):36–41.PubMedCrossRef
68.
go back to reference Gillibrand R, Stevenson J. The extended health belief model applied to the experience of diabetes in young people. Br J Health Psychol. 2006;11(Pt 1):155–69.PubMedCrossRef Gillibrand R, Stevenson J. The extended health belief model applied to the experience of diabetes in young people. Br J Health Psychol. 2006;11(Pt 1):155–69.PubMedCrossRef
69.
go back to reference Cline RR, Farley JF, Hansen RA, Schommer JC. Osteoporosis beliefs and antiresorptive medication use. Maturitas. 2005;50(3):196–208.PubMedCrossRef Cline RR, Farley JF, Hansen RA, Schommer JC. Osteoporosis beliefs and antiresorptive medication use. Maturitas. 2005;50(3):196–208.PubMedCrossRef
70.
go back to reference McHorney CA, Schousboe JT, Cline RR, Weiss TW. The impact of osteoporosis medication beliefs and side-effect experiences on non-adherence to oral bisphosphonates. Curr Med Res Opin. 2007;23(12):3137–52.PubMedCrossRef McHorney CA, Schousboe JT, Cline RR, Weiss TW. The impact of osteoporosis medication beliefs and side-effect experiences on non-adherence to oral bisphosphonates. Curr Med Res Opin. 2007;23(12):3137–52.PubMedCrossRef
71.
go back to reference Yood RA, Mazor KM, Andrade SE, Emani S, Chan W, Kahler KH. Patient decision to initiate therapy for osteoporosis: the influence of knowledge and beliefs. J Gen Intern Med. 2008;23(11):1815–21.PubMedCrossRef Yood RA, Mazor KM, Andrade SE, Emani S, Chan W, Kahler KH. Patient decision to initiate therapy for osteoporosis: the influence of knowledge and beliefs. J Gen Intern Med. 2008;23(11):1815–21.PubMedCrossRef
72.
go back to reference • Schousboe JT, Dowd BE, Davison ML, Kane RL. Association of medication attitudes with non-persistence and non-compliance with medication to prevent fractures. Osteoporos Int. 2010;21(11):1899–909. This study is unique in that it shows the relative importance of different medication attitudes and beliefs, included perceived self efficacy on self-reported persistence and compliance with fracture prevention medications. • Schousboe JT, Dowd BE, Davison ML, Kane RL. Association of medication attitudes with non-persistence and non-compliance with medication to prevent fractures. Osteoporos Int. 2010;21(11):1899–909. This study is unique in that it shows the relative importance of different medication attitudes and beliefs, included perceived self efficacy on self-reported persistence and compliance with fracture prevention medications.
73.
go back to reference • Schousboe JT, Davison ML, Dowd B, Thiede Call K, Johnson P, Kane RL. Predictors of patients' perceived need for medication to prevent fracture. Med Care. 2011;49(3):273–80. This studyis unique in that it illustrates the relative importance of the quality of the patientphysician relationship and objective indicators of fracture risk, adjusted for each other, on patient perceived necessity of fracture prevention medication. • Schousboe JT, Davison ML, Dowd B, Thiede Call K, Johnson P, Kane RL. Predictors of patients' perceived need for medication to prevent fracture. Med Care. 2011;49(3):273–80. This studyis unique in that it illustrates the relative importance of the quality of the patientphysician relationship and objective indicators of fracture risk, adjusted for each other, on patient perceived necessity of fracture prevention medication.
74.
go back to reference Solomon DH, Brookhart MA, Tsao P, Sundaresan D, Andrade SE, Mazor K, et al. Predictors of very low adherence with medications for osteoporosis: towards development of a clinical prediction rule. Osteoporos Int. 2011;22(6):1737–43.PubMedCrossRef Solomon DH, Brookhart MA, Tsao P, Sundaresan D, Andrade SE, Mazor K, et al. Predictors of very low adherence with medications for osteoporosis: towards development of a clinical prediction rule. Osteoporos Int. 2011;22(6):1737–43.PubMedCrossRef
76.
go back to reference Resnick B, Wehren L, Orwig D. Reliability and validity of the self-efficacy and outcome expectations for osteoporosis medication adherence scales. Orthop Nurs. 2003;22(2):139–47.PubMedCrossRef Resnick B, Wehren L, Orwig D. Reliability and validity of the self-efficacy and outcome expectations for osteoporosis medication adherence scales. Orthop Nurs. 2003;22(2):139–47.PubMedCrossRef
77.
go back to reference Bloom G, Standing H, Lloyd R. Markets, information asymmetry and health care: towards new social contracts. Soc Sci Med. 2008;66(10):2076–87.PubMedCrossRef Bloom G, Standing H, Lloyd R. Markets, information asymmetry and health care: towards new social contracts. Soc Sci Med. 2008;66(10):2076–87.PubMedCrossRef
78.
go back to reference Thorne SE, Robinson CA. Reciprocal trust in health care relationships. J Adv Nurs. 1988;13(6):782–9.PubMedCrossRef Thorne SE, Robinson CA. Reciprocal trust in health care relationships. J Adv Nurs. 1988;13(6):782–9.PubMedCrossRef
79.
go back to reference Hall MA, Dugan E, Zheng B, Mishra AK. Trust in physicians and medical institutions: what is it, can it be measured, and does it matter? Milbank Q. 2001;79(4):613–39. v.PubMedCrossRef Hall MA, Dugan E, Zheng B, Mishra AK. Trust in physicians and medical institutions: what is it, can it be measured, and does it matter? Milbank Q. 2001;79(4):613–39. v.PubMedCrossRef
80.
go back to reference Goff SL, Mazor KM, Meterko V, Dodd K, Sabin J. Patients' beliefs and preferences regarding doctors' medication recommendations. J Gen Intern Med. 2008;23(3):236–41.PubMedCrossRef Goff SL, Mazor KM, Meterko V, Dodd K, Sabin J. Patients' beliefs and preferences regarding doctors' medication recommendations. J Gen Intern Med. 2008;23(3):236–41.PubMedCrossRef
81.
go back to reference Buller M, Buller D. Physicians' communication style and patient satisfaction. J Heal Soc Behav. 1987;28:375–88.CrossRef Buller M, Buller D. Physicians' communication style and patient satisfaction. J Heal Soc Behav. 1987;28:375–88.CrossRef
82.
go back to reference Charles C, Gafni A, Whelan T. Decision-making in the physician-patient encounter: revisiting the shared treatment decision-making model. Soc Sci Med. 1999;49(5):651–61.PubMedCrossRef Charles C, Gafni A, Whelan T. Decision-making in the physician-patient encounter: revisiting the shared treatment decision-making model. Soc Sci Med. 1999;49(5):651–61.PubMedCrossRef
83.
go back to reference Jahng KH, Martin LR, Golin CE, DiMatteo MR. Preferences for medical collaboration: patientphysician congruence and patient outcomes. Patient Educ Couns. 2005;57(3):308–14.PubMedCrossRef Jahng KH, Martin LR, Golin CE, DiMatteo MR. Preferences for medical collaboration: patientphysician congruence and patient outcomes. Patient Educ Couns. 2005;57(3):308–14.PubMedCrossRef
84.
go back to reference • Douglas F, Petrie KJ, Cundy T, Horne A, Gamble G, Grey A. Differing perceptions of intervention thresholds for fracture risk: a survey of patients and doctors. Osteoporos Int. 2012;23(8):2135–40. This study is an important, recent documentation of how patients and physicians perceive fracture risks and use of medications to lower those risks differently.PubMedCrossRef • Douglas F, Petrie KJ, Cundy T, Horne A, Gamble G, Grey A. Differing perceptions of intervention thresholds for fracture risk: a survey of patients and doctors. Osteoporos Int. 2012;23(8):2135–40. This study is an important, recent documentation of how patients and physicians perceive fracture risks and use of medications to lower those risks differently.PubMedCrossRef
85.
go back to reference Cadarette SM, Carney G, Baek D, Gunraj N, Paterson JM, Dormuth CR. Osteoporosis medication prescribing in British Columbia and Ontario: impact of public drug coverage. Osteoporos Int. 2012;23(4):1475–80.PubMedCrossRef Cadarette SM, Carney G, Baek D, Gunraj N, Paterson JM, Dormuth CR. Osteoporosis medication prescribing in British Columbia and Ontario: impact of public drug coverage. Osteoporos Int. 2012;23(4):1475–80.PubMedCrossRef
86.
go back to reference Soumerai SB, McLaughlin TJ, Ross-Degnan D, Casteris CS, Bollini P. Effects of a limit on Medicaid drug-reimbursement benefits on the use of psychotropic agents and acute mental health services by patients with schizophrenia. N Engl J Med. 1994;331(10):650–5.PubMedCrossRef Soumerai SB, McLaughlin TJ, Ross-Degnan D, Casteris CS, Bollini P. Effects of a limit on Medicaid drug-reimbursement benefits on the use of psychotropic agents and acute mental health services by patients with schizophrenia. N Engl J Med. 1994;331(10):650–5.PubMedCrossRef
87.
go back to reference Goldman DP, Joyce GF, Escarce JJ, Pace JE, Solomon MD, Laouri M, et al. Pharmacy benefits and the use of drugs by the chronically ill. JAMA. 2004;291(19):2344–50.PubMedCrossRef Goldman DP, Joyce GF, Escarce JJ, Pace JE, Solomon MD, Laouri M, et al. Pharmacy benefits and the use of drugs by the chronically ill. JAMA. 2004;291(19):2344–50.PubMedCrossRef
88.
go back to reference Zafran N, Liss Z, Peled R, Sherf M, Reuveni H. Incidence and causes for failure of treatment of women with proven osteoporosis. Osteoporos Int. 2005;16(11):1375–83.PubMedCrossRef Zafran N, Liss Z, Peled R, Sherf M, Reuveni H. Incidence and causes for failure of treatment of women with proven osteoporosis. Osteoporos Int. 2005;16(11):1375–83.PubMedCrossRef
89.
go back to reference Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther. 2001;23(8):1296–310.PubMedCrossRef Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther. 2001;23(8):1296–310.PubMedCrossRef
90.
go back to reference Eisen SA, Miller DK, Woodward RS, Spitznagel E, Przybeck TR. The effect of prescribed daily dose frequency on patient medication compliance. Arch Intern Med. 1990;150(9):1881–4.PubMedCrossRef Eisen SA, Miller DK, Woodward RS, Spitznagel E, Przybeck TR. The effect of prescribed daily dose frequency on patient medication compliance. Arch Intern Med. 1990;150(9):1881–4.PubMedCrossRef
91.
go back to reference Wroe AL. Intentional and unintentional nonadherence: a study of decision making. J Behav Med. 2002;25(4):355–72.PubMedCrossRef Wroe AL. Intentional and unintentional nonadherence: a study of decision making. J Behav Med. 2002;25(4):355–72.PubMedCrossRef
92.
go back to reference Silverman SL, Schousboe JT, Gold DT. Oral bisphosphonate compliance and persistence: a matter of choice? Osteoporos Int. 2011;22(1):21–6.PubMedCrossRef Silverman SL, Schousboe JT, Gold DT. Oral bisphosphonate compliance and persistence: a matter of choice? Osteoporos Int. 2011;22(1):21–6.PubMedCrossRef
93.
go back to reference Kripalani S, Gatti ME, Jacobson TA. Association of age, health literacy, and medication management strategies with cardiovascular medication adherence. Patient Educ Couns. 2010;81(2):177–81.PubMedCrossRef Kripalani S, Gatti ME, Jacobson TA. Association of age, health literacy, and medication management strategies with cardiovascular medication adherence. Patient Educ Couns. 2010;81(2):177–81.PubMedCrossRef
94.
go back to reference Berkman ND, Sheridan SL, Donahue KE, Halpern DJ, Crotty K. Low health literacy and health outcomes: an updated systematic review. Ann Intern Med. 2011;155(2):97–107.PubMed Berkman ND, Sheridan SL, Donahue KE, Halpern DJ, Crotty K. Low health literacy and health outcomes: an updated systematic review. Ann Intern Med. 2011;155(2):97–107.PubMed
95.
go back to reference Elliott RA, Shinogle JA, Peele P, Bhosle M, Hughes DA, Elliott RA, et al. Understanding medication compliance and persistence from an economics perspective. Value Health. 2008;11(4):600–10.PubMedCrossRef Elliott RA, Shinogle JA, Peele P, Bhosle M, Hughes DA, Elliott RA, et al. Understanding medication compliance and persistence from an economics perspective. Value Health. 2008;11(4):600–10.PubMedCrossRef
96.
go back to reference Roelofsma PH, van der Pligt J. On the psychology of time preference and human decisions: introduction to the special issue. Acta Psychol (Amst). 2001;108(2):91–3.CrossRef Roelofsma PH, van der Pligt J. On the psychology of time preference and human decisions: introduction to the special issue. Acta Psychol (Amst). 2001;108(2):91–3.CrossRef
97.
go back to reference Read D, Loewenstein G. Time and decision: introduction to the special issue. J Behav Decis Mak. 2000;13:141–4.CrossRef Read D, Loewenstein G. Time and decision: introduction to the special issue. J Behav Decis Mak. 2000;13:141–4.CrossRef
98.
go back to reference Sozou PD, Seymour RM, Sozou PD, Seymour RM. Augmented discounting: interaction between ageing and time-preference behaviour. Proc R Soc London, Ser B. 2003;270(1519):1047–53.CrossRef Sozou PD, Seymour RM, Sozou PD, Seymour RM. Augmented discounting: interaction between ageing and time-preference behaviour. Proc R Soc London, Ser B. 2003;270(1519):1047–53.CrossRef
Metadata
Title
Adherence with Medications Used to Treat Osteoporosis: Behavioral Insights
Author
John T. Schousboe
Publication date
01-03-2013
Publisher
Current Science Inc.
Published in
Current Osteoporosis Reports / Issue 1/2013
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-013-0133-8

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