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Current Oncology Reports
Published in: Current Oncology Reports 5/2021

01-05-2021 | giant cell tumor | Orthopedic Oncology (JA Abraham, Section Editor)

Giant Cell Tumor of Bone: An Update

Authors: Atrayee Basu Mallick, Sant P. Chawla

Published in: Current Oncology Reports | Issue 5/2021

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Abstract

Purpose of Review

To highlight the new developments in the management of advanced giant cell tumor of bone, a rare locally aggressive benign tumor, which was traditionally managed with surgery alone by either curettage and local adjuvant therapy, wide resection, or marginal excision. Here, we review the current role of systemic therapy for management of locally advanced or metastatic giant cell tumor of bone (GCTB).

Recent Findings

The elucidation of the pathophysiology of giant cell tumor of bone, especially with regards to the role of nuclear factor kappa B ligand (RANKL), has led to the Food and Drug Administration (FDA) approval of denosumab in the management of locally advanced or metastatic GCTB.

Summary

For advanced giant cell tumor where surgical resection alone can cause severe morbidity, the paradigm has shifted from local treatment alone to multidisciplinary management with the consideration of use of denosumab.
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Metadata
Title
Giant Cell Tumor of Bone: An Update
Authors
Atrayee Basu Mallick
Sant P. Chawla
Publication date
01-05-2021
Publisher
Springer US
Published in
Current Oncology Reports / Issue 5/2021
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-021-01047-5

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