Skip to main content
Top
Published in: Current Oncology Reports 5/2021

01-05-2021 | Radiotherapy | Interventional Oncology (DC Madoff, Section Editor)

Percutaneous Management of Recurrent Head and Neck Cancer: Current Role and Evolving Principles in the Multidisciplinary Setting

Authors: Lawrence Han Hwee Quek, Ming Yann Lim, Timothy Cheo, Hui Lin Teo, Uei Pua

Published in: Current Oncology Reports | Issue 5/2021

Login to get access

Abstract

Purpose of Review

In this review, we will outline the role of percutaneous interventional radiological management of recurrent head and neck (H&N) cancer in the context of a multidisciplinary setting which consists of surgery, radiation therapy, as well as established and evolving systemic therapies that may impact current practice.

Recent Findings

Management of recurrent H&N cancer is complex, with attention to the preservation of function and minimal treatment-related morbidity. The favored treatment modalities in local recurrence previously treated with radiotherapy are surgical resection, and if unresectable, for chemotherapy as definitive treatment, or as a prelude to resection if there is good tumor response. Unfortunately, some of these patients are too frail for major surgery or to withstand the toxicity of chemotherapy. There is a gap for effective local therapy without the morbidity of surgery, toxicity of re-irradiation, and systemic side effects of chemotherapy. Percutaneous interventions have the potential to bridge that gap as well as provide palliative symptomatic treatment for patients that have exhausted all treatment options.

Summary

In the multidisciplinary setting involving the treatment of complex recurrent H&N cancer, percutaneous management now plays a viable and effective role with a foothold in this team-based approach.
Literature
5.
go back to reference NCCN Clinical Practice Guidelines in Oncology. Head and Neck Cancers. Version 1.2019 – March 6 2019. NCCN Clinical Practice Guidelines in Oncology. Head and Neck Cancers. Version 1.2019 – March 6 2019.
7.
go back to reference Lim MY, Zafereo M. "Salvage Neck dissection: indications, workup and technical consideration." In: Stack BC Jr, Moreno MA, editors. Neck dissection. USA: Thieme Medical Publishers Lim MY, Zafereo M. "Salvage Neck dissection: indications, workup and technical consideration." In: Stack BC Jr, Moreno MA, editors. Neck dissection. USA: Thieme Medical Publishers
11.
go back to reference • Hamoir M, Schmitz S, Suarez C, et al. The current role of salvage surgery in recurrent head and neck squamous cell carcinoma. Cancers (Basel). 2018;10(8):267. https://doi.org/10.3390/cancers10080267. An essential review that examine the criteria for selection of patients that will benefit from salvage surgery through predictive modelling based on preoperative information as well as identifying patients with postoperative prognostic factors predicting high risk of recurrence.CrossRef • Hamoir M, Schmitz S, Suarez C, et al. The current role of salvage surgery in recurrent head and neck squamous cell carcinoma. Cancers (Basel). 2018;10(8):267. https://​doi.​org/​10.​3390/​cancers10080267. An essential review that examine the criteria for selection of patients that will benefit from salvage surgery through predictive modelling based on preoperative information as well as identifying patients with postoperative prognostic factors predicting high risk of recurrence.CrossRef
14.
go back to reference • Ward MC, Riaz N, Caudell JJ, Dunlap NE, Isrow D, Zakem SJ, et al. Refining patient selection for reirradiation of head and neck squamous carcinoma in the IMRT era: a multi-institution cohort study by the MIRI Collaborative. Int J Radiat Oncol Biol Phys. 2018;100(3):586–94. https://doi.org/10.1016/j.ijrobp.2017.06.012. This study informed outcomes and expectations with IMRT-based re-irradiation. Three distinct subgroups were identified which can guide patient selection for therapy and clinical trial design.CrossRefPubMed • Ward MC, Riaz N, Caudell JJ, Dunlap NE, Isrow D, Zakem SJ, et al. Refining patient selection for reirradiation of head and neck squamous carcinoma in the IMRT era: a multi-institution cohort study by the MIRI Collaborative. Int J Radiat Oncol Biol Phys. 2018;100(3):586–94. https://​doi.​org/​10.​1016/​j.​ijrobp.​2017.​06.​012. This study informed outcomes and expectations with IMRT-based re-irradiation. Three distinct subgroups were identified which can guide patient selection for therapy and clinical trial design.CrossRefPubMed
18.
go back to reference • Burtness B, Harrington KJ, Greil R, et al. Pembrolizumab alone or with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomized, open-label, phase 3 study. Lancet. 2019;394:1915–28. https://doi.org/10.1016/S0140-6736(19)32591-7. The KEYNOTE-048 3-arm trial established pembrolizumab monotherapy or pembrolizumab plus chemotherapy as the new standard of care for systemic therapy in the first line setting.CrossRefPubMed • Burtness B, Harrington KJ, Greil R, et al. Pembrolizumab alone or with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomized, open-label, phase 3 study. Lancet. 2019;394:1915–28. https://​doi.​org/​10.​1016/​S0140-6736(19)32591-7. The KEYNOTE-048 3-arm trial established pembrolizumab monotherapy or pembrolizumab plus chemotherapy as the new standard of care for systemic therapy in the first line setting.CrossRefPubMed
19.
go back to reference Guigay J, Fayette J, Mesia R, et al. TPExtreme randomized trial: TPEx versus Extreme regimen in 1st line recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). J Clin Oncol. 2019;37(15_suppl):6002.CrossRef Guigay J, Fayette J, Mesia R, et al. TPExtreme randomized trial: TPEx versus Extreme regimen in 1st line recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). J Clin Oncol. 2019;37(15_suppl):6002.CrossRef
21.
34.
go back to reference • Guenette JP, Tuncali K, Himes N, Shyn PB, Lee TC. Percutaneous image-guided cryoablation of head and neck tumors for local control, preservation of functional status, and pain relief. AJR Am J Roentgenol. 2017;208(2):453–8. https://doi.org/10.2214/AJR.16.16446. One of the few early studies that documented percutaneous image-guided cryoablation can offer a potentially less morbid minimally invasive treatment option than salvage head and neck surgery.CrossRefPubMed • Guenette JP, Tuncali K, Himes N, Shyn PB, Lee TC. Percutaneous image-guided cryoablation of head and neck tumors for local control, preservation of functional status, and pain relief. AJR Am J Roentgenol. 2017;208(2):453–8. https://​doi.​org/​10.​2214/​AJR.​16.​16446. One of the few early studies that documented percutaneous image-guided cryoablation can offer a potentially less morbid minimally invasive treatment option than salvage head and neck surgery.CrossRefPubMed
Metadata
Title
Percutaneous Management of Recurrent Head and Neck Cancer: Current Role and Evolving Principles in the Multidisciplinary Setting
Authors
Lawrence Han Hwee Quek
Ming Yann Lim
Timothy Cheo
Hui Lin Teo
Uei Pua
Publication date
01-05-2021
Publisher
Springer US
Published in
Current Oncology Reports / Issue 5/2021
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-021-01045-7

Other articles of this Issue 5/2021

Current Oncology Reports 5/2021 Go to the issue

Genitourinary Cancers (DP Petrylak and JW Kim, Section Editors)

Prostate-Specific Membrane Antigen (PSMA)-Targeted Radionuclide Therapies for Prostate Cancer

Breast Cancer (AS Zimmer, Section Editor)

Rare Breast Cancer Subtypes

Orthopedic Oncology (JA Abraham, Section Editor)

Giant Cell Tumor of Bone: An Update

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine