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Current Oncology Reports

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01-04-2017 | Neuro-oncology (S Nagpal, Section Editor)

The Effect of Molecular Diagnostics on the Treatment of Glioma

Authors: Nancy Ann Oberheim Bush, Nicholas Butowski

Published in: Current Oncology Reports | Issue 4/2017

Abstract

Purpose of Review

This review summarizes the use of molecular diagnostics in glioma and its effect on the development of novel therapeutics and management decisions.

Recent Findings

Genomic and proteomic profiling of brain tumors has provided significant expansion of our understanding of oncogenesis, characterization, and prognostication of brain tumors. Molecular markers such as MGMT, EGFR, IDH, 1p19q, ATRX, TERT, FGFR-TACC, and BRAF are now being used to classify brain tumors as well as influence management decisions. Several of these markers are also being used as therapeutic targets.

Summary

We review the use of several molecular diagnostics in gliomas and discuss their impact on drug development and clinical trial design. In the future, molecular characterization based on a specific genomic, proteomic as well as transcriptomes for bioformatics analysis will provide clinicians the ability to rationally select drugs with actionable targets for each patient.

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Title: The Effect of Molecular Diagnostics on the Treatment of Glioma
Authors: Nancy Ann Oberheim Bush
Nicholas Butowski
Publication date: 01-04-2017
Publisher: Springer US
Published in: Current Oncology Reports / Issue 4/2017
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-017-0585-6

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