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Current Oncology Reports

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01-04-2017 | Neuro-oncology (S Nagpal, Section Editor)

Immune Checkpoint Inhibitors in Gliomas

Authors: Aaron C. Tan, Amy B. Heimberger, Mustafa Khasraw

Published in: Current Oncology Reports | Issue 4/2017

Abstract

Purpose of Review

Malignant gliomas result in disproportionately high morbidity and mortality compared with other primary tumors, and progression of disease is inevitable. Novel therapies to improve outcomes are needed and immune checkpoint inhibitors hold significant promise.

Recent Findings

A limited body of preclinical evidence suggests that checkpoint inhibitors may be effective treatment for gliomas. Biomarkers to identify characteristics of gliomas responsive to these therapies will be essential. These may include mismatch repair deficiency and high mutational load that might be germline, somatic, or acquired after therapy. Evidence on the use of immune checkpoint inhibitors in gliomas is evolving. Clinical trials are underway and results are eagerly awaited.

Summary

Understanding the role of immune checkpoint inhibitors in combination with other treatment modalities for gliomas is crucial to the improvement of outcomes. The design and conduct of future clinical trials need to account for increasingly complex treatment options.

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Title: Immune Checkpoint Inhibitors in Gliomas
Authors: Aaron C. Tan
Amy B. Heimberger
Mustafa Khasraw
Publication date: 01-04-2017
Publisher: Springer US
Published in: Current Oncology Reports / Issue 4/2017
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-017-0586-5

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The Role of Hypofractionated Radiotherapy in Prostate Cancer

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Changing the Therapeutic Landscape in Non-small Cell Lung Cancers: the Evolution of Comprehensive Molecular Profiling Improves Access to Therapy

Prolymphocytic Leukemia: New Insights in Diagnosis and in Treatment

The Effect of Molecular Diagnostics on the Treatment of Glioma

Contributions of the Japanese Gynecologic Oncology Group (JGOG) in Improving the Quality of Life in Women With Gynecological Malignancies

Keynote webinar | Spotlight on antibody–drug conjugates in cancer