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Published in:

01-08-2010

Mineralocorticoid Receptor Antagonists and the Metabolic Syndrome

Authors: Amir Tirosh, Rajesh Garg, Gail K. Adler

Published in: Current Hypertension Reports | Issue 4/2010

Abstract

Key components of the metabolic syndrome (MetS), ie, obesity and insulin resistance, are associated with increased aldosterone production and mineralocorticoid receptor (MR) activation. Both MetS and hyperaldosteronism are proinflammatory and pro-oxidative states associated with cardiovascular disease. This review discusses emerging data that MR activation may contribute to abnormalities seen in MetS. In view of these data, MR antagonists may be beneficial in MetS, not only by controlling hypertension but also by reversing inflammation, oxidative stress, and defective insulin signaling at the cellular-molecular level. Clinical trials have demonstrated benefits of MR antagonists in heart failure, hypertension, and diabetic nephropathy, but additional trials are needed to demonstrate the clinical significance of MR blockade in MetS.

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Title: Mineralocorticoid Receptor Antagonists and the Metabolic Syndrome
Authors: Amir Tirosh
Rajesh Garg
Gail K. Adler
Publication date: 01-08-2010
Publisher: Current Science Inc.
Published in: Current Hypertension Reports / Issue 4/2010
Print ISSN: 1522-6417
Electronic ISSN: 1534-3111
DOI: https://doi.org/10.1007/s11906-010-0126-2

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