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Current Hepatology Reports

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01-09-2019 | Hepatitis B | Hepatitis B (JK Lim, Section Editor)

Epidemiology, Diagnosis, and Management of Bone Disease in Patients with Chronic HBV Infection

Authors: Mike T. Wei, Mindie H. Nguyen, Ramsey Cheung

Published in: Current Hepatology Reports | Issue 3/2019

Abstract

Purpose of Review

Chronic hepatitis B (CHB) and treatment may be associated with increased risk of osteopenia/osteoporosis. Here, we review the prevalence of osteopenia/osteoporosis among patients with CHB and the effect of antiviral therapy on bone density. We also highlight screening and management strategies for bone disease among patients with CHB.

Recent Findings

While there are concerns with first-line antiviral therapy such as tenofovir disoproxil fumarate in the development of osteopenia/osteoporosis, the available data remain rather unclear. However, with the development of tenofovir alafenamide, these concerns may be mitigated. At present, EASL recommends dual-energy X-ray absorption (DEXA) scans for patients with osteoporotic risk factors, with a repeat DEXA scan based upon baseline findings.

Summary

Patients with CHB have higher incidence and prevalence of osteopenia/osteoporosis compared with patients without CHB. Further studies are needed to understand the impact of antiviral therapy on bone therapy, and more CHB specific recommendations are needed for bone health management.

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Title: Epidemiology, Diagnosis, and Management of Bone Disease in Patients with Chronic HBV Infection
Authors: Mike T. Wei
Mindie H. Nguyen
Ramsey Cheung
Publication date: 01-09-2019
Publisher: Springer US
Keywords: Hepatitis B
Bisphosphonate
Tenofovir
Entecavir
Osteoporosis
Osteoporosis
Dexamethasone
Published in: Current Hepatology Reports / Issue 3/2019
Electronic ISSN: 2195-9595
DOI: https://doi.org/10.1007/s11901-019-00481-1

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