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Current Hematologic Malignancy Reports
Published in: Current Hematologic Malignancy Reports 6/2019

Open Access 01-12-2019 | Chronic Myeloid Leukemia | Chronic Myeloid Leukemias (G Saglio, Section Editor)

Towards a Personalized Treatment of Patients with Chronic Myeloid Leukemia

Authors: Florence Rabian, Etienne Lengline, Delphine Rea

Published in: Current Hematologic Malignancy Reports | Issue 6/2019

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Abstract

Purpose of Review

Treatment goals and ambitions have even been upwardly revised since demonstration was made that under certain conditions, treatment-free remission was possible. Herein, we will discuss on how to try tailoring treatment choices to the unique characteristics of each patient.

Recent Findings

Since the first-generation ATP-competitive TKI imatinib was made available in the clinic in 2001, second-generation drugs such as dasatinib, nilotinib and bosutinib and the third-generation TKI ponatinib have broadened the therapeutic armamentarium, providing effective salvage against intolerance and different types of resistance, or as frontline options.

Summary

Management and outcomes of patients with chronic myeloid leukemia have been revolutionized by the discovery, development, and approval of BCR-ABL tyrosine kinase inhibitors (TKIs). Most patients can now expect a near-to normal life expectancy and acceptable quality of life on life-long treatment, providing awareness and avoidance of harmful adverse events, which depend on each TKI safety profile and patient personal background.
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Metadata
Title
Towards a Personalized Treatment of Patients with Chronic Myeloid Leukemia
Authors
Florence Rabian
Etienne Lengline
Delphine Rea
Publication date
01-12-2019
Publisher
Springer US
Published in
Current Hematologic Malignancy Reports / Issue 6/2019
Print ISSN: 1558-8211
Electronic ISSN: 1558-822X
DOI
https://doi.org/10.1007/s11899-019-00546-4

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