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Current Hematologic Malignancy Reports

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01-10-2019 | Acute Myeloid Leukemia | Molecular Testing and Diagnostics (J Khoury, Section Editor)

Acute Myeloid Leukemia: from Mutation Profiling to Treatment Decisions

Authors: Courtney DiNardo, Curtis Lachowiez

Published in: Current Hematologic Malignancy Reports | Issue 5/2019

Abstract

Purpose of Review

Awareness of the molecular landscape of AML has improved AML care over the last 5 years. This review summarizes updates regarding the diagnostic and therapeutic relevance of key mutations in AML.

Recent Findings

Molecular mutations in genes including NPM1, CEBPA, FLT3, IDH1/2, TP53, RUNX1, and ASXL1 provide important prognostic and/or therapeutic information in AML, including best treatment strategies, transplant recommendations, and significance of MRD detection. Mutational analysis has led to the recognition of new entities including hereditary leukemia syndromes and clonal hematopoiesis of indeterminate potential (CHIP). FLT3 and IDH1/2 mutations are the focus of targeted therapies in the treatment of AML.

Summary

Advances in the molecular characterization of AML have provided an improved understanding of leukemogenesis and AML risk stratification, improved disease monitoring techniques, optimized therapeutic strategies, and have led to the development of novel molecular-targeted therapeutics. Ongoing genomic advances will continue to improve upon the outcome of patients with AML.

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Title: Acute Myeloid Leukemia: from Mutation Profiling to Treatment Decisions
Authors: Courtney DiNardo
Curtis Lachowiez
Publication date: 01-10-2019
Publisher: Springer US
Keywords: Acute Myeloid Leukemia
Targeted Therapy
Gilteritinib
Published in: Current Hematologic Malignancy Reports / Issue 5/2019
Print ISSN: 1558-8211
Electronic ISSN: 1558-822X
DOI: https://doi.org/10.1007/s11899-019-00535-7

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