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Current Hematologic Malignancy Reports

Published in:

01-10-2017 | CART and Immunotherapy (M Ruella, Section Editor)

Immune Dysfunction in Non-Hodgkin Lymphoma: Avenues for New Immunotherapy-Based Strategies

Author: Lorenzo Falchi

Published in: Current Hematologic Malignancy Reports | Issue 5/2017

Abstract

Purpose of this Review

The present review focuses on key aspects of non-Hodgkin lymphoma (NHL) evasion of immune surveillance and how these can be leveraged to devise effective immunotherapy strategies.

Recent Findings

In recent years, significant progress has been made in the field of cancer immunotherapy. In particular, the remarkable clinical results of anti-programmed death (PD)-1/PD-ligand (L)1 antibodies are revolutionizing the treatment approach to multiple solid and hematologic tumors. In patients with B or T cell NHL, immune checkpoint inhibition has produced mixed results, in part owing to the high complexity of the tumor immune microenvironment. Rationally designed combinations of PD-1/PD-L1 blockers with other antibody- or cell-based immunotherapies, or small molecules are being tested in clinical trials.

Summary

A clearer understanding of the relationship between host immune dysfunction and cancer development and growth, often referred to as cancer “immuno-editing,” has enabled the discovery and successful clinical application of several immunotherapeutic agents, such as the immune checkpoint inhibitors (ICI).

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Title: Immune Dysfunction in Non-Hodgkin Lymphoma: Avenues for New Immunotherapy-Based Strategies
Author: Lorenzo Falchi
Publication date: 01-10-2017
Publisher: Springer US
Published in: Current Hematologic Malignancy Reports / Issue 5/2017
Print ISSN: 1558-8211
Electronic ISSN: 1558-822X
DOI: https://doi.org/10.1007/s11899-017-0410-1

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Immune Dysfunction in Non-Hodgkin Lymphoma: Avenues for New Immunotherapy-Based Strategies

Abstract

Purpose of this Review

Recent Findings

Summary

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Abstract

Purpose of this Review

Recent Findings

Summary

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