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01-04-2015 | Pathophysiology: Neuroendocrine, Vascular, and Metabolic Factors (SD Katz, Section Editor)

Pathophysiology of Sepsis-Related Cardiac Dysfunction: Driven by Inflammation, Energy Mismanagement, or Both?

Authors: Konstantinos Drosatos, Anastasios Lymperopoulos, Peter Johannes Kennel, Nina Pollak, P. Christian Schulze, Ira J. Goldberg

Published in: Current Heart Failure Reports | Issue 2/2015

Abstract

Sepsis is a systemic inflammatory response that follows bacterial infection. Cardiac dysfunction is an important consequence of sepsis that affects mortality and has been attributed to either elevated inflammation or suppression of both fatty acid and glucose oxidation and eventual ATP depletion. Moreover, cardiac adrenergic signaling is compromised in septic patients and this aggravates further heart function. While anti-inflammatory therapies are important for the treatment of the disease, administration of anti-inflammatory drugs did not improve survival in septic patients. This review article summarizes findings on inflammatory and other mechanisms that are triggered in sepsis and affect cardiac function and mortality. Particularly, it focuses on the effects of the disease in metabolic pathways, as well as in adrenergic signaling and the potential interplay of the latter with inflammation. It is suggested that therapeutic approaches should include combination of anti-inflammatory treatments, stimulation of energy production, and restoration of adrenergic signaling in the heart.

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Title: Pathophysiology of Sepsis-Related Cardiac Dysfunction: Driven by Inflammation, Energy Mismanagement, or Both?
Authors: Konstantinos Drosatos
Anastasios Lymperopoulos
Peter Johannes Kennel
Nina Pollak
P. Christian Schulze
Ira J. Goldberg
Publication date: 01-04-2015
Publisher: Springer US
Published in: Current Heart Failure Reports / Issue 2/2015
Print ISSN: 1546-9530
Electronic ISSN: 1546-9549
DOI: https://doi.org/10.1007/s11897-014-0247-z

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Pathophysiology of Sepsis-Related Cardiac Dysfunction: Driven by Inflammation, Energy Mismanagement, or Both?

Abstract

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Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

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Abstract

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