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Current Diabetes Reports

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Open Access 23-06-2022 | Vascular Dementia | Obesity (K Gadde and P Singh, Section Editors)

Metabolic Syndrome and Vascular-Associated Cognitive Impairment: a Focus on Preclinical Investigations

Author: Trisha A. Jenkins

Published in: Current Diabetes Reports | Issue 8/2022

Abstract

Purpose of Review

Metabolic syndrome is associated with an increased risk of vascular cognitive impairment or, in the more extreme, vascular dementia. Animal models are used to investigate the relationship between pathology and behaviour. This review summarizes the latest understanding of the role of the hippocampus and prefrontal cortex in vascular cognitive impairment, the influence of inflammation in this association while also commenting on some of the latest interventions proposed.

Recent Findings

Models of vascular cognitive impairment and vascular dementia, whether they develop from an infarct or non-infarct base, demonstrate increased neuroinflammation, reduced neuronal function and deficits in prefrontal and hippocampal-associated cognitive domains. Promising new research shows agents and environmental interventions that inhibit central oxidative stress and inflammation can reverse both pathology and cognitive dysfunction.

Summary

While preclinical studies suggest that reversal of deficits in vascular cognitive impairment models is possible, replication in patients still needs to be demonstrated.

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Title: Metabolic Syndrome and Vascular-Associated Cognitive Impairment: a Focus on Preclinical Investigations
Author: Trisha A. Jenkins
Publication date: 23-06-2022
Publisher: Springer US
Keywords: Vascular Dementia
Vascular Dementia
Published in: Current Diabetes Reports / Issue 8/2022
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI: https://doi.org/10.1007/s11892-022-01475-y

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Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

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