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Current Colorectal Cancer Reports
Published in: Current Colorectal Cancer Reports 1/2019

01-02-2019 | Bevacizumab | Systemic Therapies in Colorectal Cancer (SM Kazmi, Section Editor)

Current Status of Maintenance Systemic Therapies in Metastatic Colorectal Cancer: 2018 Update

Authors: Julia Mann, Alexander Stein

Published in: Current Colorectal Cancer Reports | Issue 1/2019

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Abstract

Purpose of Review

Current systemic management of MCRC includes periods of intensive induction treatment followed by surgery and/or local ablation or maintenance or complete stop. This article is an update of the 2017 review by Quidde et al. and evaluates the most recent data on maintenance strategies in MCRC.

Recent Findings

Induction followed by maintenance and if feasible re-induction treatment does not seem to be inferior to continuous full-dose treatment for patients with MCRC responding to first-line combination regimen but without options for secondary resection or local ablation. Active maintenance seems to be superior to complete stop after at least 3 months of induction treatment in terms of progression-free survival and may add some benefit in terms of OS. The addition of PD-L1 inhibition to maintenance was not effective. The choice of the respective maintenance strategy may be personalised taking into account disease and patient characteristic, choice of induction treatment and response, treatment tolerability and quality of life.

Summary

Patients with MCRC and no options of secondary resection or local ablation should be considered for maintenance treatment.
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Metadata
Title
Current Status of Maintenance Systemic Therapies in Metastatic Colorectal Cancer: 2018 Update
Authors
Julia Mann
Alexander Stein
Publication date
01-02-2019
Publisher
Springer US
Published in
Current Colorectal Cancer Reports / Issue 1/2019
Print ISSN: 1556-3790
Electronic ISSN: 1556-3804
DOI
https://doi.org/10.1007/s11888-019-00426-2

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