Skip to main content
Top
Published in: Current Cardiology Reports 2/2019

01-02-2019 | Heart Failure | Invasive Electrophysiology and Pacing (EK Heist, Section Editor)

Management of Atrial Fibrillation in Patients with Heart Failure: Time to Implement Ablation Control

Authors: Alex Baher, Nassir F. Marrouche

Published in: Current Cardiology Reports | Issue 2/2019

Login to get access

Abstract

Purpose of the Review

Atrial fibrillation (AF) in patients with heart failure and reduced systolic ejection fraction (HFrEF) is common and associated with increased morbidity and mortality, and managing AF in this population has been particularly challenging with sparse data regarding the optimal treatment strategy.

Recent Findings

Recent data suggests that rhythm control with catheter ablation can be of particular benefit to patients with coexisting AF and HFrEF. Recent randomized control trials actually suggest that catheter ablation could potentially improve mortality in this particular patient population. This is in stark contrast to the current practice recommendations that reserve catheter ablation for symptomatic AF in the general population.

Summary

In this paper, we will review the most current randomized controlled studies using catheter ablation in HFrEF patients with the hope to increase awareness of the potential mortality benefits the need for prioritization of catheter ablation in HFrEF patients in the next AF management guidelines.
Literature
2.
go back to reference Wattigney WA, Mensah GA, Croft JB. Increased atrial fibrillation mortality: United States, 1980-1998. Am J Epidemiol. 2002;155(9):819–26.CrossRef Wattigney WA, Mensah GA, Croft JB. Increased atrial fibrillation mortality: United States, 1980-1998. Am J Epidemiol. 2002;155(9):819–26.CrossRef
6.
go back to reference Coplen SE, Antman EM, Berlin JA, Hewitt P, Chalmers TC. Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. A meta-analysis of randomized control trials. Circulation. 1990;82(4):1106–16.CrossRef Coplen SE, Antman EM, Berlin JA, Hewitt P, Chalmers TC. Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. A meta-analysis of randomized control trials. Circulation. 1990;82(4):1106–16.CrossRef
11.
go back to reference January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC Jr, et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2014;64(21):e1–76. https://doi.org/10.1016/j.jacc.2014.03.022. January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC Jr, et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2014;64(21):e1–76. https://​doi.​org/​10.​1016/​j.​jacc.​2014.​03.​022.
16.
go back to reference Dries DL, Exner DV, Gersh BJ, Domanski MJ, Waclawiw MA, Stevenson LW. Atrial fibrillation is associated with an increased risk for mortality and heart failure progression in patients with asymptomatic and symptomatic left ventricular systolic dysfunction: a retrospective analysis of the SOLVD trials. Studies of left ventricular dysfunction. J Am Coll Cardiol. 1998;32(3):695–703 doi:papers3://publication/uuid/7A1580D5-F722-4BC5-A7D6-A2B9C86A413A.CrossRef Dries DL, Exner DV, Gersh BJ, Domanski MJ, Waclawiw MA, Stevenson LW. Atrial fibrillation is associated with an increased risk for mortality and heart failure progression in patients with asymptomatic and symptomatic left ventricular systolic dysfunction: a retrospective analysis of the SOLVD trials. Studies of left ventricular dysfunction. J Am Coll Cardiol. 1998;32(3):695–703 doi:papers3://publication/uuid/7A1580D5-F722-4BC5-A7D6-A2B9C86A413A.CrossRef
22.
go back to reference • Di Biase L, Mohanty P, Mohanty S, Santangeli P, Trivedi C, Lakkireddy D, et al. Ablation versus amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device: results from the AATAC multicenter randomized trial. Circulation. 2016;133(17):1637–44. https://doi.org/10.1161/CIRCULATIONAHA.115.019406 This study is a large prospective randomized controlled trial in patients with persistent atrial fibrillation and heart failure and reduced ejection fraction which compared freedom from atrial fibrillation in patients undergoing catheter ablation to amiodarone which is currently the most known effective antoarrhythmic therapy. In this study, mortality was included as a secondary endpoint. CrossRefPubMed • Di Biase L, Mohanty P, Mohanty S, Santangeli P, Trivedi C, Lakkireddy D, et al. Ablation versus amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device: results from the AATAC multicenter randomized trial. Circulation. 2016;133(17):1637–44. https://​doi.​org/​10.​1161/​CIRCULATIONAHA.​115.​019406 This study is a large prospective randomized controlled trial in patients with persistent atrial fibrillation and heart failure and reduced ejection fraction which compared freedom from atrial fibrillation in patients undergoing catheter ablation to amiodarone which is currently the most known effective antoarrhythmic therapy. In this study, mortality was included as a secondary endpoint. CrossRefPubMed
24.
go back to reference •• Marrouche NF, Brachmann J, Andresen D, Siebels J, Boersma L, Jordaens L, et al. Catheter ablation for atrial fibrillation with heart failure. N Engl J Med. 2018;378(5):417–27. https://doi.org/10.1056/NEJMoa1707855 This study is currently the only large prospective randomized controlled trial that includes hard endpoints of all-cause mortality and heart failure hospitalization as the primary endpoint and included patients with both paroxysmal and persistnet atrial fibrillation and heart failure with reduced ejection fraction. CrossRefPubMed •• Marrouche NF, Brachmann J, Andresen D, Siebels J, Boersma L, Jordaens L, et al. Catheter ablation for atrial fibrillation with heart failure. N Engl J Med. 2018;378(5):417–27. https://​doi.​org/​10.​1056/​NEJMoa1707855 This study is currently the only large prospective randomized controlled trial that includes hard endpoints of all-cause mortality and heart failure hospitalization as the primary endpoint and included patients with both paroxysmal and persistnet atrial fibrillation and heart failure with reduced ejection fraction. CrossRefPubMed
28.
go back to reference Flaker GC, Blackshear JL, McBride R, Kronmal RA, Halperin JL, Hart RG. Antiarrhythmic drug therapy and cardiac mortality in atrial fibrillation. The stroke prevention in atrial fibrillation investigators. J Am Coll Cardiol. 1992;20(3):527–32.CrossRef Flaker GC, Blackshear JL, McBride R, Kronmal RA, Halperin JL, Hart RG. Antiarrhythmic drug therapy and cardiac mortality in atrial fibrillation. The stroke prevention in atrial fibrillation investigators. J Am Coll Cardiol. 1992;20(3):527–32.CrossRef
29.
go back to reference Waldo AL, Camm AJ, DeRuyter H, Friedman PL, MacNeil DJ, Pauls JF, et al. Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD investigators. Survival with oral d-sotalol. Lancet. 1996;348(9019):7–12.CrossRef Waldo AL, Camm AJ, DeRuyter H, Friedman PL, MacNeil DJ, Pauls JF, et al. Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD investigators. Survival with oral d-sotalol. Lancet. 1996;348(9019):7–12.CrossRef
36.
go back to reference Elgendy AY, Mahmoud AN, Khan MS, Sheikh MR, Mojadidi MK, Omer M, et al. Meta-analysis comparing catheter-guided ablation versus conventional medical therapy for patients with atrial fibrillation and heart failure with reduced ejection fraction. Am J Cardiol. 2018;122:806–13. https://doi.org/10.1016/j.amjcard.2018.05.009. Elgendy AY, Mahmoud AN, Khan MS, Sheikh MR, Mojadidi MK, Omer M, et al. Meta-analysis comparing catheter-guided ablation versus conventional medical therapy for patients with atrial fibrillation and heart failure with reduced ejection fraction. Am J Cardiol. 2018;122:806–13. https://​doi.​org/​10.​1016/​j.​amjcard.​2018.​05.​009.
37.
go back to reference Chen C, Zhou X, Zhu M, Chen S, Chen J, Cai H, et al. Catheter ablation versus medical therapy for patients with persistent atrial fibrillation: a systematic review and meta-analysis of evidence from randomized controlled trials. J Interv Card Electrophysiol. 2018;52(1):9–18. https://doi.org/10.1007/s10840-018-0349-8. Chen C, Zhou X, Zhu M, Chen S, Chen J, Cai H, et al. Catheter ablation versus medical therapy for patients with persistent atrial fibrillation: a systematic review and meta-analysis of evidence from randomized controlled trials. J Interv Card Electrophysiol. 2018;52(1):9–18. https://​doi.​org/​10.​1007/​s10840-018-0349-8.
38.
go back to reference Briceno DF, Markman TM, Lupercio F, Romero J, Liang JJ, Villablanca PA, et al. Catheter ablation versus conventional treatment of atrial fibrillation in patients with heart failure with reduced ejection fraction: a systematic review and meta-analysis of randomized controlled trials. J Interv Card Electrophysiol. 2018;53:19–29. https://doi.org/10.1007/s10840-018-0425-0.CrossRefPubMed Briceno DF, Markman TM, Lupercio F, Romero J, Liang JJ, Villablanca PA, et al. Catheter ablation versus conventional treatment of atrial fibrillation in patients with heart failure with reduced ejection fraction: a systematic review and meta-analysis of randomized controlled trials. J Interv Card Electrophysiol. 2018;53:19–29. https://​doi.​org/​10.​1007/​s10840-018-0425-0.CrossRefPubMed
Metadata
Title
Management of Atrial Fibrillation in Patients with Heart Failure: Time to Implement Ablation Control
Authors
Alex Baher
Nassir F. Marrouche
Publication date
01-02-2019
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 2/2019
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-019-1093-0

Other articles of this Issue 2/2019

Current Cardiology Reports 2/2019 Go to the issue

Heart Failure (HJ Eisen, Section Editor)

Chagas Cardiomyopathy in Latin America Review

Pericardial Disease (AL Klein and CL Jellis, Section Editors)

Radical Pericardiectomy for Pericardial Diseases