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Current Cardiology Reports
Published in: Current Cardiology Reports 11/2018

01-11-2018 | Myocardial Disease (A Abbate, Section Editor)

Skeletal Muscle Myopathy in Heart Failure: the Role of Ejection Fraction

Authors: Mara Paneroni, Evasio Pasini, Laura Comini, Michele Vitacca, Federico Schena, Simonetta Scalvini, Massimo Venturelli

Published in: Current Cardiology Reports | Issue 11/2018

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Abstract

Purpose of Review

This review summarizes: (1) the structural and functional features coupled with pathophysiological factors responsible of skeletal muscle myopathy (SMM) in both heart failure with reduced (HFrEF) and preserved (HFpEF) ejection fraction and (2) the role of exercise as treatment of SMM in these HF-related phenotypes.

Recent Findings

The recent literature showed two main phenotypes of heart failure (HF): (1) HFrEF primarily due to a systolic dysfunction of the left ventricle and (2) HFpEF, mainly related to a diastolic dysfunction. Exercise intolerance is one of most disabling symptoms of HF and it is shown that persists after the normalization of the central hemodynamic impairments by therapy and/or cardiac surgery including heart transplant. A specific skeletal muscle myopathy (SMM) has been defined as one of the main causes of exercise intolerance in HF.

Summary

The SMM has been well described in the last 20 years in the HFrEF; on the contrary, few studies are available in HFpEF. Recent evidences have revealed that exercise training counteracts HF-related SMM and in turn ameliorates exercise intolerance.
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Metadata
Title
Skeletal Muscle Myopathy in Heart Failure: the Role of Ejection Fraction
Authors
Mara Paneroni
Evasio Pasini
Laura Comini
Michele Vitacca
Federico Schena
Simonetta Scalvini
Massimo Venturelli
Publication date
01-11-2018
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 11/2018
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-018-1056-x

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