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01-03-2018 | Nuclear Cardiology (V Dilsizian, Section Editor)

¹⁸F-FDG-PET/CT Imaging to Diagnose Septic Emboli and Mycotic Aneurysms in Patients with Endocarditis and Cardiac Device Infections

Authors: Nidaa Mikail, Khadija Benali, Besma Mahida, Jonathan Vigne, Fabien Hyafil, François Rouzet, Dominique Le Guludec

Published in: Current Cardiology Reports | Issue 3/2018

Abstract

Purpose of review

This review analyzes recent studies evaluating the diagnostic value of ¹⁸F-FDG-PET/CT for the detection of peripheral emboli and secondary infectious foci in patients with infective endocarditis and cardiac device infections.

Recent findings

Detection of extracardiac septic localizations in patients with infective endocarditis and cardiac device infections is crucial, as it may impact the diagnosis, prognosis, and therapeutic management. Recent literature substantiated the clinical usefulness of ¹⁸F-FDG-PET/CT in this setting.

Summary

¹⁸F-FDG-PET/CT has proven its high diagnostic value for the detection of peripheral emboli in patients with infective endocarditis and cardiac device infections, substantially affecting patients’ outcome and treatment. A multimodal approach, combining the high sensitivity of ¹⁸F-FDG-PET/CT with morphological imaging seems promising.

Bruun NE, Habib G, Thuny F, Sogard P. Cardiac imaging in infectious endocarditis. Eur Heart J. 2014;35(10):642–32.CrossRef

Gomes A, Glaudemans AW, Touw DJ, van Melle JP, Willems TP, Maass AH, et al. Diagnostic value of imaging in infective endocarditis: a systematic review. Lancet Infect Dis. 2017;17(1):e1-e14

Slipczuk L, Codolosa JN, Davila CD, Romero-Corral A, Yun J, Pressman GS, et al. Infective endocarditis epidemiology over five decades: a systematic review. PLoS ONE. 2013;8(12):e82665.CrossRefPubMedPubMedCentral

Htwe TH, Khardori NM. Cardiac emergencies: infective endocarditis, pericarditis, and myocarditis. Med Clin North Am. 2012;96(6):1149–69.CrossRefPubMed

Romeyer-Bouchard C, Da Costa A, Dauphinot V, Messier M, Bisch L, Samuel B, et al. Prevalence and risk factors related to infections of cardiac resynchronization therapy devices. Eur Heart J. 2010;31(2):203–10.CrossRefPubMed

Prutkin JM, Reynolds MR, Bao H, Curtis JP, Al-Khatib SM, Aggarwal S. Rates of and factors associated with infection in 200 909 Medicare implantable cardioverter-defibrillator implants: results from the National Cardiovascular Data Registry. Circulation. 2014;130(13):1037–43.CrossRefPubMed

Duval X, Delahaye F, Alla F, Tattevin P, Obadia J-F, Le Moing V, et al. Temporal trends in infective endocarditis in the context of prophylaxis guideline modifications: three successive population-based surveys. J Am Coll Cardiol. 2012;59(22):1968–76.CrossRefPubMed

Murdoch DR, Corey GR, Hoen B, Miró JM, Fowler VG, Bayer AS, et al. Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study. Arch Intern Med. 2009;169(5):463–73.CrossRefPubMedPubMedCentral

Nery PB, Fernandes R, Nair GM, Sumner GL, Ribas CS, Menon SM, et al. Device-related infection among patients with pacemakers and implantable defibrillators: incidence, risk factors, and consequences. J Cardiovasc Electrophysiol. 2010;21(7):786–90.PubMed

10.

Bannay A, Hoen B, Duval X, Obadia J-F, Selton-Suty C, Le Moing V, et al. The impact of valve surgery on short- and long-term mortality in left-sided infective endocarditis: do differences in methodological approaches explain previous conflicting results? Eur Heart J. 2011;32(16):2003–15.CrossRefPubMed

11.

Mocchegiani R, Nataloni M. Complications of infective endocarditis. Cardiovasc Hematol Disord Drug Targets. 2009;9(4):240–8.CrossRefPubMed

12.

Fauchier L, Pericart L, Bourguignon T, Bernard L, Clementy N, Angoulvant D, et al. Prediction of Systemic Septic Embolism in Patients With Left-Sided Infective Endocarditis. J Am Coll Cardiol. 2017;69(15):1992–3.CrossRefPubMed

13.

Chu VH, Cabell CH, Benjamin DK, Kuniholm EF, Fowler VG, Engemann J, et al. Early predictors of in-hospital death in infective endocarditis. Circulation. 2004;109(14):1745–9.CrossRefPubMed

14.

Dickerman SA, Abrutyn E, Barsic B, Bouza E, Cecchi E, Moreno A, et al. The relationship between the initiation of antimicrobial therapy and the incidence of stroke in infective endocarditis: an analysis from the ICE Prospective Cohort Study (ICE-PCS). Am Heart J. 2007;154(6):1086–94.CrossRefPubMed

15.

Ruttmann E, Willeit J, Ulmer H, Chevtchik O, Höfer D, Poewe W, et al. Neurological outcome of septic cardioembolic stroke after infective endocarditis. Stroke. 2006;37(8):2094–9.CrossRefPubMed

16.

Athan E, Chu VH, Tattevin P, Selton-Suty C, Jones P, Naber C, et al. Clinical characteristics and outcome of infective endocarditis involving implantable cardiac devices. JAMA. 2012;307(16):1727–35.CrossRefPubMed

17.

Rodriguez Y, Greenspon AJ, Sohail MR, Carrillo RG. Cardiac device-related endocarditis complicated by spinal abscess. Pacing Clin Electrophysiol. 2012;35(3):269–74.CrossRefPubMed

18.

Chahoud J, Sharif Yakan A, Saad H, Kanj SS. Right-Sided Infective Endocarditis and Pulmonary Infiltrates: An Update. Cardiol Rev. 2016;24(5):230–7.CrossRefPubMed

19.

Akinosoglou K, Apostolakis E, Marangos M, Pasvol G. Native valve right sided infective endocarditis. Eur J Intern Med. 2013;24(6):510–9.CrossRefPubMed

20.

Ortiz C, López J, García H, Sevilla T, Revilla A, Vilacosta I, et al. Clinical classification and prognosis of isolated right-sided infective endocarditis. Medicine (Baltimore). 2014;93(27):e137.CrossRefPubMedPubMedCentral

21.

Mylonakis E, Calderwood SB. Infective endocarditis in adults. N Engl J Med 2001;345(18):1318-1330.

22.

Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta J-P, Del Zotti F, et al. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J. 2015;36(44):3075–128.CrossRefPubMed

23.

Hasbun R, Vikram HR, Barakat LA, Buenconsejo J, Quagliarello VJ. Complicated left-sided native valve endocarditis in adults: risk classification for mortality. JAMA. 2003;289(15):1933–40.CrossRefPubMed

24.

Anderson DJ, Goldstein LB, Wilkinson WE, Corey GR, Cabell CH, Sanders LL, et al. Stroke location, characterization, severity, and outcome in mitral vs aortic valve endocarditis. Neurology. 2003;61(10):1341–6.CrossRefPubMed

25.

Hill EE, Herijgers P, Claus P, Vanderschueren S, Peetermans WE, Herregods M-C. Clinical and echocardiographic risk factors for embolism and mortality in infective endocarditis. Eur J Clin Microbiol Infect Dis. 2008;27(12):1159–64.CrossRefPubMed

26.

Tornos P, Iung B, Permanyer-Miralda G, Baron G, Delahaye F, Gohlke-Bärwolf C, et al. Infective endocarditis in Europe: lessons from the Euro heart survey. Heart. 2005;91(5):571–5.CrossRefPubMedPubMedCentral

27.

Chen W, Kim J, Molchanova-Cook OP, Dilsizian V. The potential of FDG PET/CT for early diagnosis of cardiac device and prosthetic valve infection before morphologic damages ensue. Curr Cardiol Rep. 2014;16(3):459.CrossRefPubMed

28.

Duval X, Iung B. Extracardiac Imaging of Infective Endocarditis. Curr Infect Dis Rep. 2017;19(7):24.

29.

Millar BC, Prendergast BD, Alavi A, Moore JE. Positron emission tomography (PET): a new tool in the diagnosis of endocarditis. Heart. 2009;95(4):332–3.PubMed

30.

Millar BC, Prendergast BD, Alavi A, Moore JE. 18FDG-positron emission tomography (PET) has a role to play in the diagnosis and therapy of infective endocarditis and cardiac device infection. Int J Cardiol. 2013;167(5):1724–36.CrossRefPubMed

31.

Saby L, Laas O, Habib G, Cammilleri S, Mancini J, Tessonnier L, et al. Positron emission tomography/computed tomography for diagnosis of prosthetic valve endocarditis: increased valvular 18F-fluorodeoxyglucose uptake as a novel major criterion. J Am Coll Cardiol. 2013;61(23):2374–82.CrossRefPubMed

32.

Juneau D, Golfam M, Hazra S, Zuckier LS, Garas S, Redpath C, et al. Positron Emission Tomography and Single-Photon Emission Computed Tomography Imaging in the Diagnosis of Cardiac Implantable Electronic Device Infection: A Systematic Review and Meta-Analysis. Circ Cardiovasc Imaging. 2017;10(4).

33.

Erba PA, Sollini M, Conti U, Bandera F, Tascini C, De Tommasi SM, et al. Radiolabeled WBC scintigraphy in the diagnostic workup of patients with suspected device-related infections. JACC Cardiovasc Imaging. 2013;6(10):1075–86.CrossRefPubMed

34.

Bar-Even A, Flamholz A, Noor E, Milo R. Rethinking glycolysis: on the biochemical logic of metabolic pathways. Nat Chem Biol. 2012;8(6):509–17.CrossRefPubMed

35.

Hamacher K, Coenen HH, Stöcklin G. Efficient stereospecific synthesis of no-carrier-added 2-[18F]fluoro-2-deoxyglucose using amino-polyether supported nucleophilic fluorination. J Nucl Med. 1986;27:235–8.PubMed

36.

Boellaard R, Delgado-Bolton R, Oyen WJG, Giammarile F, Tatsch K, Eschner W, et al. FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging. 2015;42(2):328–54.CrossRefPubMed

37.

Roque A, Pizzi MN, Cuéllar-Calàbria H, Aguadé-Bruix S. 18F-FDG-PET/CT Angiography for the Diagnosis of Infective Endocarditis. Curr Cardiol Rep. 2017;19(2):15.CrossRefPubMed

38.

Taegtmeyer H, Lam T, Davogustto G. Cardiac Metabolism in Perspective. Compr Physiol. 2016;6(4):1675–99.CrossRefPubMed

39.

Stanley WC, Recchia FA, Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev. 2005;85(3):1093–129.CrossRefPubMed

40.

Knuuti J, Schelbert HR, Bax JJ. The need for standardisation of cardiac FDG PET imaging in the evaluation of myocardial viability in patients with chronic ischaemic left ventricular dysfunction. Eur J Nucl Med Mol Imaging. 2002;29(9):1257–66.CrossRefPubMed

41.

Fukuchi K, Ohta H, Matsumura K, Ishida Y. Benign variations and incidental abnormalities of myocardial FDG uptake in the fasting state as encountered during routine oncology positron emission tomography studies. Br J Radiol. 2007;80(949):3–11.CrossRefPubMed

42.

de Groot M, Meeuwis AP, Kok PJ, Corstens FH, Oyen WJ. Influence of blood glucose level, age and fasting period on non-pathological FDG uptake in heart and gut. Eur J Nucl Med Mol Imaging. 2005;32(1):98–101.CrossRefPubMed

43.

Lum D, Wandell S, Ko J, Coel M. 1. Positron Emission Tomography of thoracic malignancies. Reduction of myocardial fluorodeoxyglucose uptake artifacts with a carbohydrate restricted diet. Clin Positron Imaging. 2000;3(4):155.CrossRefPubMed

44.

Balink H, Hut E, Pol T, Flokstra FJ, Roef M. Suppression of 18F-FDG Myocardial uptake using a fat-allowed, carbohydrate-restricted diet. J Nucl Med Technol. 2011;39(3):185–9.CrossRefPubMed

45.

Williams G, Kolodny GM. Suppression of myocardial 18F-FDG uptake by preparing patients with a high-fat, low-carbohydrate diet. AJR Am J Roentgenol. 2008;190(2):W151–6.CrossRefPubMed

46.

Petersdorf RG, Beeson PB. Fever of unexplained origin: report on 100 cases. Medicine (Baltimore). 1961;40:1–30.CrossRef

47.

Petersdorf RG. Fever of unknown origin. An old friend revisited. Arch Intern Med. 1992;152(1):21–2.CrossRefPubMed

48.

Besson FL, Chaumet-Riffaud P, Playe M, Noel N, Lambotte O, Goujard C, et al. Contribution of (18)F-FDG PET in the diagnostic assessment of fever of unknown origin (FUO): a stratification-based meta-analysis. Eur J Nucl Med Mol Imaging. 2016;43(10):1887–95.CrossRefPubMed

49.

Vos FJ, Bleeker-Rovers CP, Sturm PD, Krabbe PFM, van Dijk APJ, Cuijpers MLH, et al. 18F-FDG PET/CT for detection of metastatic infection in gram-positive bacteremia. J Nucl Med. 2010;51(8):1234–40.CrossRefPubMed

50.

Vos FJ, Kullberg BJ, Sturm PD, Krabbe PFM, van Dijk APJ, Wanten GJA, et al. Metastatic infectious disease and clinical outcome in Staphylococcus aureus and Streptococcus species bacteremia. Medicine (Baltimore). 2012;91(2):86–94.CrossRefPubMed

51.

Berrevoets MAH, Kouijzer IJE, Aarntzen EHJG, Janssen MJR, De Geus-Oei L-F, Wertheim HFL, et al. (18)F-FDG-PET/CT optimizes treatment in Staphylococcus aureus bacteremia and is associated with reduced mortality. J Nucl Med. 2017;

52.

Vos FJ, Bleeker-Rovers CP, Kullberg BJ, Adang EMM, Oyen WJG. Cost-effectiveness of routine (18)F-FDG PET/CT in high-risk patients with gram-positive bacteremia. J Nucl Med. 2011;52(11):1673–8.CrossRefPubMed

53.

Blokhuis GJ, Bleeker-Rovers CP, Diender MG, Oyen WJG, Draaisma JMT, de Geus-Oei L-F. Diagnostic value of FDG-PET/(CT) in children with fever of unknown origin and unexplained fever during immune suppression. Eur J Nucl Med Mol Imaging. 2014;41(10):1916–23.CrossRefPubMed

54.

Kouijzer IJE, Vos FJ, Janssen MJR, van Dijk APJ, Oyen WJG, Bleeker-Rovers CP. The value of 18F-FDG PET/CT in diagnosing infectious endocarditis. Eur J Nucl Med Mol Imaging. 2013;40(7):1102–7.CrossRefPubMed

55.

Méndez-Echevarria A, Coronado-Poggio M, Baquero-Artigao F, Del Rosal T, Rodado-Marina S, Calvo C, et al. Septic pulmonary emboli detected by (18)F-FDG PET/CT in children with S. aureus catheter-related bacteremia. Infection. 2017;45(5):691–6.CrossRefPubMed

56.

Simons KS, Pickkers P, Bleeker-Rovers CP, Oyen WJG, van der Hoeven JG. F-18-fluorodeoxyglucose positron emission tomography combined with CT in critically ill patients with suspected infection. Intensive Care Med. 2010;36(3):504–11.CrossRefPubMed

57.

Kluge S, Braune S, Nierhaus A, Wichmann D, Derlin T, Mester J, et al. Diagnostic value of positron emission tomography combined with computed tomography for evaluating patients with septic shock of unknown origin. J Crit Care. 2012, 27, 7;(3):316.e1.

58.

Di Salvo G, Habib G, Pergola V, Avierinos JF, Philip E, Casalta JP, et al. Echocardiography predicts embolic events in infective endocarditis. J Am Coll Cardiol. 2001;37(4):1069–76.CrossRefPubMed

59.

Van Riet J, Hill EE, Gheysens O, Dymarkowski S, Herregods M-C, Herijgers P, et al. (18)F-FDG PET/CT for early detection of embolism and metastatic infection in patients with infective endocarditis. Eur J Nucl Med Mol Imaging. 2010;37(6):1189–97.CrossRefPubMed

60.

Özcan C, Asmar A, Gill S, Thomassen A, Diederichsen ACP. The value of FDG-PET/CT in the diagnostic work-up of extra cardiac infectious manifestations in infectious endocarditis. Int J Cardiovasc Imaging. 2013;29(7):1629–37.CrossRefPubMed

61.

Bonfiglioli R, Nanni C, Morigi JJ, Graziosi M, Trapani F, Bartoletti M, et al. 18F-FDG PET/CT diagnosis of unexpected extracardiac septic embolisms in patients with suspected cardiac endocarditis. Eur J Nucl Med Mol Imaging. 2013;40(8):1190–6.CrossRefPubMed

62.

Asmar A, Ozcan C, Diederichsen ACP, Thomassen A, Gill S. Clinical impact of 18F-FDG-PET/CT in the extra cardiac work-up of patients with infective endocarditis. Eur Heart J Cardiovasc Imaging. 2014;15(9):1013–9.CrossRefPubMed

63.

Kestler M, Muñoz P, Rodríguez-Créixems M, Rotger A, Jimenez-Requena F, Mari A, et al. Role of (18)F-FDG PET in Patients with Infectious Endocarditis. J Nucl Med. 2014;55(7):1093–8.CrossRefPubMed

64.

Graziosi M, Nanni C, Lorenzini M, Diemberger I, Bonfiglioli R, Pasquale F, et al. Role of 18F-FDG PET/CT in the diagnosis of infective endocarditis in patients with an implanted cardiac device: a prospective study. Eur J Nucl Med Mol Imaging. 2014;41(8):1617–23.CrossRefPubMed

65.

Tlili G, Amraoui S, Amroui S, Mesguich C, Rivière A, Bordachar P, et al. High performances of (18)F-fluorodeoxyglucose PET-CT in cardiac implantable device infections: A study of 40 patients. J Nucl Cardiol. 2015;22(4):787–98.CrossRefPubMed

66.

Pizzi MN, Roque A, Fernández-Hidalgo N, Cuéllar-Calabria H, Ferreira-González I, Gonzàlez-Alujas MT, et al. Improving the Diagnosis of Infective Endocarditis in Prosthetic Valves and Intracardiac Devices With 18F-Fluordeoxyglucose Positron Emission Tomography/Computed Tomography Angiography: Initial Results at an Infective Endocarditis Referral Center. Circulation. 2015;132(12):1113–26.CrossRefPubMed

67.

Granados U, Fuster D, Pericas JM, Llopis JL, Ninot S, Quintana E, et al. Diagnostic Accuracy of 18F-FDG PET/CT in Infective Endocarditis and Implantable Cardiac Electronic Device Infection: A Cross-Sectional Study. J Nucl Med. 2016;57(11):1726–32.CrossRefPubMed

68.

•• Amraoui S, Tlili G, Sohal M, Berte B, Hindié E, Ritter P, et al. Contribution of PET Imaging to the Diagnosis of Septic Embolism in Patients With Pacing Lead Endocarditis. JACC Cardiovasc Imaging. 2016;9(3):283–90. This is the first article to specifically address, in a prospective manner, the diagnostic performances of ¹⁸ F-FDG-PET/CT for the diagnosis of peripheral localizations in patients with known CIED-infection.

69.

Baman TS, Gupta SK, Valle JA, Yamada E. Risk factors for mortality in patients with cardiac device-related infection. Circ Arrhythm Electrophysiol. 2009;2(2):129–34.CrossRefPubMed

70.

Hill EE, Herijgers P, Claus P, Vanderschueren S, Herregods M-C, Peetermans WE. Infective endocarditis: changing epidemiology and predictors of 6-month mortality: a prospective cohort study. Eur Heart J. 2007;28(2):196–203.CrossRefPubMed

71.

Spence AM, Muzi M, Mankoff DA, O’Sullivan SF, Link JM, Lewellen TK, et al. 18F-FDG PET of gliomas at delayed intervals: improved distinction between tumor and normal gray matter. J Nucl Med. 2004;45(10):1653–9.PubMed

72.

Cooper HA, Thompson EC, Laureno R, Fuisz A, Mark AS, Lin M, et al. Subclinical brain embolization in left-sided infective endocarditis: results from the evaluation by MRI of the brains of patients with left-sided intracardiac solid masses (EMBOLISM) pilot study. Circulation. 2009;120(7):585–91.CrossRefPubMed

73.

Iung B, Tubiana S, Klein I, Messika-Zeitoun D, Brochet E, Lepage L, et al. Determinants of cerebral lesions in endocarditis on systematic cerebral magnetic resonance imaging: a prospective study. Stroke. 2013;44(11):3056–62.CrossRefPubMed

74.

Hess A, Klein I, Iung B, Lavallée P, Ilic-Habensus E, Dornic Q, et al. Brain MRI findings in neurologically asymptomatic patients with infective endocarditis. AJNR Am J Neuroradiol. 2013;34(8):1579–84.CrossRefPubMed

75.

Chakraborty T, Scharf E, Rabinstein AA, DeSimone D, El Rafei A, Brinjikji W, et al. Utility of Brain Magnetic Resonance Imaging in the Surgical Management of Infective Endocarditis. J Stroke Cerebrovasc Dis. 2017;26(11):2527–35.CrossRefPubMed

76.

Champey J, Pavese P, Bouvaist H, Kastler A, Krainik A, Francois P. Value of brain MRI in infective endocarditis: a narrative literature review. Eur J Clin Microbiol Infect Dis. 2016;35(2):159–68.CrossRefPubMed

77.

Calais J, Pasi N, Nguyen V, Hyafil F. Mycotic aneurysm in a pulmonary artery detected with 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging. Eur Heart J. 2017.

78.

Teoh EJ, Backhouse L, Chandrasekaran B, Sabharwal NK, Beale AM, Gleeson FV, et al. Mycotic aneurysm of the superior mesenteric artery and other sequelae of prosthetic valve endocarditis on 18F-FDG PET/CT. Eur J Nucl Med Mol Imaging. u;41(10):1993–4.

79.

Mikail N, Benali K, Ou P, Slama J, Hyafil F, Le Guludec D, et al. Detection of Mycotic Aneurysms of Lower Limbs by Whole-Body (18)F-FDG-PET. JACC Cardiovasc Imaging. 2015;8(7):859–62.CrossRefPubMed

80.

Vieira MLC, Grinberg M, Pomerantzeff PMA, Andrade JL, Mansur AJ. Repeated echocardiographic examinations of patients with suspected infective endocarditis. Heart. 2004;90(9):1020–4.CrossRefPubMedPubMedCentral

81.

Delahaye F, M’Hammedi A, Guerpillon B, de Gevigney G, Boibieux A, Dauwalder O, et al. Systematic Search for Present and Potential Portals of Entry for Infective Endocarditis. J Am Coll Cardiol. 2016;67(2):151–8.CrossRefPubMed

82.

Chu VH. When the Cat’s Out of the Bag: Searching for Portals of Entry in Infective Endocarditis. J Am Coll Cardiol. 2016;67(2):159–61.CrossRefPubMed

83.

Gupta S, Bhattacharya D, Acharya AN, Majumdar S, Ranjan P, Das S. Colorectal carcinoma in young adults: a retrospective study on Indian patients: 2000-2008. Colorectal Dis. 2010;12(10 Online):e182–9.CrossRefPubMed

84.

Pericàs JM, Corredoira J, Miró JM. Hospital Clínic–Lucus Augusti Working Group for Endocarditis. Colorectal Adenomas. N Engl J Med. 2016;375(4):387–8.CrossRefPubMed

85.

Sun L-M, Wu J-N, Lin C-L, Day J-D, Liang J-A, Liou L-R, et al. Infective Endocarditis and Cancer Risk: A Population-Based Cohort Study. Medicine (Baltimore). 2016;95(12):e3198.CrossRefPubMedPubMedCentral

86.

Hyafil F, Rouzet F, Lepage L, Benali K, Raffoul R, Duval X, et al. Role of radiolabelled leucocyte scintigraphy in patients with a suspicion of prosthetic valve endocarditis and inconclusive echocardiography. Eur Heart J Cardiovasc Imaging. 2013;14(6):586–94.CrossRefPubMed

87.

Rouzet F, Chequer R, Benali K, Lepage L, Ghodbane W, Duval X, et al. Respective performance of 18F-FDG PET and radiolabeled leukocyte scintigraphy for the diagnosis of prosthetic valve endocarditis. J Nucl Med. 2014;55(12):1980–5.CrossRefPubMed

88.

Erba PA, Conti U, Lazzeri E, Sollini M, Doria R, De Tommasi SM, et al. Added value of 99mTc-HMPAO-labeled leukocyte SPECT/CT in the characterization and management of patients with infectious endocarditis. J Nucl Med. 2012;53(8):1235–43.CrossRefPubMed

89.

Mikail N, Benali K, Dossier A, Bouleti C, Hyafil F, Le Guludec D, et al. Additional diagnostic value of combined Angio-CT and 18FDG-PET in infectious aortitis. JACC Cardiovasc Imaging. In press.

90.

Mandry D, Tatopoulos A, Chevalier-Mathias E, Lemarié J, Bollaert PE, Roch V, et al. 18F-fluorodeoxyglucose positron emission tomography combined with whole-body computed tomographic angiography in critically ill patients with suspected severe sepsis with no definite diagnosis. Eur J Nucl Med Mol Imaging. 2014;41(10):1924–30.CrossRefPubMed

91.

Yang ZL, Zhang LJ. PET/MRI of central nervous system: current status and future perspective. Eur Radiol. 2016;26(10):3534–41.CrossRefPubMed

92.

Werner P, Barthel H, Drzezga A, Sabri O. Current status and future role of brain PET/MRI in clinical and research settings. Eur J Nucl Med Mol Imaging. 2015;42(3):512–26.CrossRefPubMed

93.

Nensa F, Beiderwellen K, Heusch P, Wetter A. Clinical applications of PET/MRI: current status and future perspectives. Diagn Interv Radiol. 2014;20(5):438–47.CrossRefPubMedPubMedCentral

94.

Ratib O, Nkoulou R. Potential applications of PET/MR imaging in cardiology. J Nucl Med. 2014;55(Supplement 2):40S–6S.CrossRefPubMed

95.

Schindler TH. Cardiovascular PET/MR: “Not the end, but the beginning”. J Nucl Cardiol. 2017;24(3):1098–100.CrossRefPubMed

96.

Schindler TH. Cardiovascular PET/MR imaging: Quo Vadis? J Nucl Cardiol. 2017;24(3):1007–18.CrossRefPubMed

97.

Wong D, Rubinshtein R, Keynan Y. Alternative Cardiac Imaging Modalities to Echocardiography for the Diagnosis of Infective Endocarditis. Am J Cardiol. 2016;118(9):1410–8.CrossRefPubMed

Title: 18F-FDG-PET/CT Imaging to Diagnose Septic Emboli and Mycotic Aneurysms in Patients with Endocarditis and Cardiac Device Infections
Authors: Nidaa Mikail
Khadija Benali
Besma Mahida
Jonathan Vigne
Fabien Hyafil
François Rouzet
Dominique Le Guludec
Publication date: 01-03-2018
Publisher: Springer US
Published in: Current Cardiology Reports / Issue 3/2018
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI: https://doi.org/10.1007/s11886-018-0956-0

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