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Current Atherosclerosis Reports
Published in: Current Atherosclerosis Reports 10/2014

01-10-2014 | Nutrition (JP Foreyt, Section Editor)

Metabolically Healthy Obesity—Does it Exist?

Authors: Patchaya Boonchaya-anant, Caroline M. Apovian

Published in: Current Atherosclerosis Reports | Issue 10/2014

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Abstract

The prevalence of obesity has been increasing worldwide over the past 30 years and is a major public health concern. Obesity is known to be associated with metabolic disturbances including insulin resistance and inflammation; however, there is a subset of obese subjects who have normal metabolic profiles, and they have been identified as the metabolically healthy obese (MHO). Several studies have described MHO as obese individuals who have high levels of insulin sensitivity and the absence of diabetes, dyslipidemia, or hypertension. The prevalence of MHO varies from 20 to 30 % among obese individuals. This review will discuss the MHO phenotype; the differences between MHO and metabolically unhealthy obese (MUO) individuals; and the possible underlying mechanisms including adipocyte differentiation, immune regulation, and cellular energy metabolism.
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Metadata
Title
Metabolically Healthy Obesity—Does it Exist?
Authors
Patchaya Boonchaya-anant
Caroline M. Apovian
Publication date
01-10-2014
Publisher
Springer US
Published in
Current Atherosclerosis Reports / Issue 10/2014
Print ISSN: 1523-3804
Electronic ISSN: 1534-6242
DOI
https://doi.org/10.1007/s11883-014-0441-1

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