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Diabetologia
Published in: Diabetologia 9/2012

01-09-2012 | Review

Adiponectin: mechanistic insights and clinical implications

Authors: A. T. Turer, P. E. Scherer

Published in: Diabetologia | Issue 9/2012

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Abstract

Adiponectin is an adipocyte-derived secretory protein that has been very widely studied over the past 15 years. A multitude of different functions have been attributed to this adipokine. It has been characterised in vitro at the level of tissue culture systems and in vivo through genetic manipulation of rodent models. It is also widely accepted as a biomarker in clinical studies. Originating in adipose tissue, generally positive metabolic effects have been attributed to adiponectin. In this review, we briefly discuss the key characteristics of this interesting but very complex molecule, highlight recent results in the context of its mechanism of action and summarise some of the key epidemiological data that helped establish adiponectin as a robust biomarker for insulin sensitivity, cardiovascular disease and many additional disease phenomena.
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Metadata
Title
Adiponectin: mechanistic insights and clinical implications
Authors
A. T. Turer
P. E. Scherer
Publication date
01-09-2012
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 9/2012
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-012-2598-x

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