Published in:
01-11-2020 | Immunodeficiency | Pediatric Allergy and Immunology (W Dolen, Section Editor)
B Cell Disorders in Children: Part II
Authors:
Dixie D. Griffin, William K. Dolen
Published in:
Current Allergy and Asthma Reports
|
Issue 11/2020
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Abstract
Purpose of Review
B cell disorders result in decreased levels or function of immunoglobulins in an individual. Genetic mutations have been reported in a variety of B cell disorders. This review, in follow-up to a previous review, describes some rare B cell disorders as well as their known underlying genetic etiologies.
Recent Findings
Genetic studies identify and permit precise classification of an increasing number of B cell disorders, leading to a greater understanding of B cell development and function.
Summary
The B cell disorders are rare diseases. While clinicians are most familiar with X-linked agammaglobulinemia and so-called common variable immunodeficiency (CVID), there are many causes of hypogammaglobulinemia. Genetic testing provides a specific diagnosis, offers useful information for genetic counseling, and can identify previously unrecognized B cell disorders.