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Published in: Current Allergy and Asthma Reports 11/2020

01-11-2020 | Immunodeficiency | Pediatric Allergy and Immunology (W Dolen, Section Editor)

B Cell Disorders in Children: Part II

Authors: Dixie D. Griffin, William K. Dolen

Published in: Current Allergy and Asthma Reports | Issue 11/2020

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Abstract

Purpose of Review

B cell disorders result in decreased levels or function of immunoglobulins in an individual. Genetic mutations have been reported in a variety of B cell disorders. This review, in follow-up to a previous review, describes some rare B cell disorders as well as their known underlying genetic etiologies.

Recent Findings

Genetic studies identify and permit precise classification of an increasing number of B cell disorders, leading to a greater understanding of B cell development and function.

Summary

The B cell disorders are rare diseases. While clinicians are most familiar with X-linked agammaglobulinemia and so-called common variable immunodeficiency (CVID), there are many causes of hypogammaglobulinemia. Genetic testing provides a specific diagnosis, offers useful information for genetic counseling, and can identify previously unrecognized B cell disorders.
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Metadata
Title
B Cell Disorders in Children: Part II
Authors
Dixie D. Griffin
William K. Dolen
Publication date
01-11-2020
Publisher
Springer US
Published in
Current Allergy and Asthma Reports / Issue 11/2020
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-020-00963-z

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