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Current Allergy and Asthma Reports

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01-09-2020 | Immunodeficiency | Pediatric Allergy and Immunology (W Dolen, Section Editor)

B Cell Disorders in Children—Part I

Authors: Bailee Gilchrist, William K. Dolen

Published in: Current Allergy and Asthma Reports | Issue 9/2020

Abstract

Purpose of Review

The advent of enhanced genetic testing has allowed for the discovery of gene defects underlying two broad categories of antibody deficiency in children: agammaglobulinemia and common variable immunodeficiency (CVID). This review describes the underlying gene defects and the clinical manifestations.

Recent Findings

Because novel monogenetic defects have been discovered in both categories, a strict dichotomous classification of B cell disorders as either X-linked agammaglobulinemia or common variable immunodeficiency is no longer appropriate.

Summary

Advances in genetic testing technology and the decreasing cost of such testing permit more precise diagnosis of B cell disorders, more helpful information for genetic counselors, and a better understanding of the complex process of B cell development and function. More disorders await discovery.

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Title: B Cell Disorders in Children—Part I
Authors: Bailee Gilchrist
William K. Dolen
Publication date: 01-09-2020
Publisher: Springer US
Keyword: Immunodeficiency
Published in: Current Allergy and Asthma Reports / Issue 9/2020
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-020-00938-0

At a glance: The STEP trials

Springer Medicine

B Cell Disorders in Children—Part I

Abstract

Purpose of Review

Recent Findings

Summary

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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