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Published in: Current Allergy and Asthma Reports 9/2020

01-09-2020 | Mites | Pediatric Allergy and Immunology (W Dolen, Section Editor)

The Indoor Environment and Childhood Asthma

Authors: Nicole Akar-Ghibril, Wanda Phipatanakul

Published in: Current Allergy and Asthma Reports | Issue 9/2020

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Abstract

Purpose of Review

Sensitization and exposure to triggers in the indoor environment, including aeroallergens, indoor air pollution, and environmental tobacco smoke, have a significant role in asthma development and morbidity. This review discusses indoor environmental exposures and their effect on children with asthma as well as environmental interventions and their role in improving asthma morbidity.

Recent Findings

Recent research has emphasized the role of aeroallergen sensitization and exposure in asthma morbidity and the importance of the school indoor environment.

Summary

There is an established association between indoor exposures and asthma development and morbidity. Recent evidence has highlighted the importance of the indoor environment in childhood asthma, particularly the role of the school indoor environment. While home environmental interventions have had mixed results, interventions in the school environment have the potential to significantly impact the health of children, and ongoing research is needed to determine their effectiveness.
Literature
2.
go back to reference Sullivan PW, Ghushchyan V, Navaratnam P, Friedman HS, Kavati A, Ortiz B, et al. The national cost of asthma among school-aged children in the United States. Ann Allergy Asthma Immunol. 2017;119(3):246–52 e1.PubMed Sullivan PW, Ghushchyan V, Navaratnam P, Friedman HS, Kavati A, Ortiz B, et al. The national cost of asthma among school-aged children in the United States. Ann Allergy Asthma Immunol. 2017;119(3):246–52 e1.PubMed
3.
go back to reference Sporik R, Holgate ST, Platts-Mills TA, Cogswell JJ. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med. 1990;323(8):502–7.PubMed Sporik R, Holgate ST, Platts-Mills TA, Cogswell JJ. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med. 1990;323(8):502–7.PubMed
4.
go back to reference Illi S, von Mutius E, Lau S, Niggemann B, Gruber C, Wahn U, et al. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet. 2006;368(9537):763–70.PubMed Illi S, von Mutius E, Lau S, Niggemann B, Gruber C, Wahn U, et al. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet. 2006;368(9537):763–70.PubMed
5.
go back to reference Langley SJ, Goldthorpe S, Craven M, Morris J, Woodcock A, Custovic A. Exposure and sensitization to indoor allergens: association with lung function, bronchial reactivity, and exhaled nitric oxide measures in asthma. J Allergy Clin Immunol. 2003;112(2):362–8.PubMed Langley SJ, Goldthorpe S, Craven M, Morris J, Woodcock A, Custovic A. Exposure and sensitization to indoor allergens: association with lung function, bronchial reactivity, and exhaled nitric oxide measures in asthma. J Allergy Clin Immunol. 2003;112(2):362–8.PubMed
6.
go back to reference Gruchalla RS, Pongracic J, Plaut M, Evans R 3rd, Visness CM, Walter M, et al. Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity. J Allergy Clin Immunol. 2005;115(3):478–85.PubMed Gruchalla RS, Pongracic J, Plaut M, Evans R 3rd, Visness CM, Walter M, et al. Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity. J Allergy Clin Immunol. 2005;115(3):478–85.PubMed
7.
go back to reference Salo PM, Arbes SJ Jr, Crockett PW, Thorne PS, Cohn RD, Zeldin DC. Exposure to multiple indoor allergens in US homes and its relationship to asthma. J Allergy Clin Immunol. 2008;121(3):678–84 e2.PubMedPubMedCentral Salo PM, Arbes SJ Jr, Crockett PW, Thorne PS, Cohn RD, Zeldin DC. Exposure to multiple indoor allergens in US homes and its relationship to asthma. J Allergy Clin Immunol. 2008;121(3):678–84 e2.PubMedPubMedCentral
8.
go back to reference Weiss ST, Horner A, Shapiro G, Sternberg AL, Childhood Asthma Management Program Research G. The prevalence of environmental exposure to perceived asthma triggers in children with mild-to-moderate asthma: data from the Childhood Asthma Management Program (CAMP). J Allergy Clin Immunol 2001;107(4):634–640. Weiss ST, Horner A, Shapiro G, Sternberg AL, Childhood Asthma Management Program Research G. The prevalence of environmental exposure to perceived asthma triggers in children with mild-to-moderate asthma: data from the Childhood Asthma Management Program (CAMP). J Allergy Clin Immunol 2001;107(4):634–640.
9.
go back to reference Arlian LG, Bernstein D, Bernstein IL, Friedman S, Grant A, Lieberman P, et al. Prevalence of dust mites in the homes of people with asthma living in eight different geographic areas of the United States. J Allergy Clin Immunol. 1992;90(3 Pt 1):292–300.PubMed Arlian LG, Bernstein D, Bernstein IL, Friedman S, Grant A, Lieberman P, et al. Prevalence of dust mites in the homes of people with asthma living in eight different geographic areas of the United States. J Allergy Clin Immunol. 1992;90(3 Pt 1):292–300.PubMed
10.
go back to reference Portnoy J, Miller JD, Williams PB, Chew GL, Miller JD, Zaitoun F, et al. Environmental assessment and exposure control of dust mites: a practice parameter. Ann Allergy Asthma Immunol. 2013;111(6):465–507.PubMedPubMedCentral Portnoy J, Miller JD, Williams PB, Chew GL, Miller JD, Zaitoun F, et al. Environmental assessment and exposure control of dust mites: a practice parameter. Ann Allergy Asthma Immunol. 2013;111(6):465–507.PubMedPubMedCentral
11.
go back to reference Dust mite allergens and asthma--a worldwide problem. J Allergy Clin Immunol. 1989;83(2 Pt 1):416–27. Dust mite allergens and asthma--a worldwide problem. J Allergy Clin Immunol. 1989;83(2 Pt 1):416–27.
12.
go back to reference Filep S, Tsay A, Vailes L, Gadermaier G, Ferreira F, Matsui E, et al. A multi-allergen standard for the calibration of immunoassays: CREATE principles applied to eight purified allergens. Allergy. 2012;67(2):235–41.PubMed Filep S, Tsay A, Vailes L, Gadermaier G, Ferreira F, Matsui E, et al. A multi-allergen standard for the calibration of immunoassays: CREATE principles applied to eight purified allergens. Allergy. 2012;67(2):235–41.PubMed
13.
go back to reference Calderon MA, Linneberg A, Kleine-Tebbe J, De Blay F. Hernandez Fernandez de Rojas D, Virchow JC, et al. Respiratory allergy caused by house dust mites: what do we really know? J Allergy Clin Immunol. 2015;136(1):38–48.PubMed Calderon MA, Linneberg A, Kleine-Tebbe J, De Blay F. Hernandez Fernandez de Rojas D, Virchow JC, et al. Respiratory allergy caused by house dust mites: what do we really know? J Allergy Clin Immunol. 2015;136(1):38–48.PubMed
14.
go back to reference Marks GB, Mihrshahi S, Kemp AS, Tovey ER, Webb K, Almqvist C, et al. Prevention of asthma during the first 5 years of life: a randomized controlled trial. J Allergy Clin Immunol. 2006;118(1):53–61.PubMed Marks GB, Mihrshahi S, Kemp AS, Tovey ER, Webb K, Almqvist C, et al. Prevention of asthma during the first 5 years of life: a randomized controlled trial. J Allergy Clin Immunol. 2006;118(1):53–61.PubMed
15.
go back to reference • Murray CS, Foden P, Sumner H, Shepley E, Custovic A, Simpson A. Preventing severe asthma exacerbations in children. A randomized trial of mite-impermeable bedcovers. Am J Respir Crit Care Med. 2017;196(2):150–8 Use of dust mite impermeable bedcovers resulted in decreased risk of hospital visits for asthma but no change in medication use or asthma exacerbations. PubMed • Murray CS, Foden P, Sumner H, Shepley E, Custovic A, Simpson A. Preventing severe asthma exacerbations in children. A randomized trial of mite-impermeable bedcovers. Am J Respir Crit Care Med. 2017;196(2):150–8 Use of dust mite impermeable bedcovers resulted in decreased risk of hospital visits for asthma but no change in medication use or asthma exacerbations. PubMed
16.
go back to reference Halken S, Host A, Niklassen U, Hansen LG, Nielsen F, Pedersen S, et al. Effect of mattress and pillow encasings on children with asthma and house dust mite allergy. J Allergy Clin Immunol. 2003;111(1):169–76.PubMed Halken S, Host A, Niklassen U, Hansen LG, Nielsen F, Pedersen S, et al. Effect of mattress and pillow encasings on children with asthma and house dust mite allergy. J Allergy Clin Immunol. 2003;111(1):169–76.PubMed
17.
go back to reference de Vries MP, van den Bemt L, Aretz K, Thoonen BP, Muris JW, Kester AD, et al. House dust mite allergen avoidance and self-management in allergic patients with asthma: randomised controlled trial. Br J Gen Pract. 2007;57(536):184–90.PubMedPubMedCentral de Vries MP, van den Bemt L, Aretz K, Thoonen BP, Muris JW, Kester AD, et al. House dust mite allergen avoidance and self-management in allergic patients with asthma: randomised controlled trial. Br J Gen Pract. 2007;57(536):184–90.PubMedPubMedCentral
18.
go back to reference Cohn RD, Arbes SJ Jr, Yin M, Jaramillo R, Zeldin DC. National prevalence and exposure risk for mouse allergen in US households. J Allergy Clin Immunol. 2004;113(6):1167–71.PubMed Cohn RD, Arbes SJ Jr, Yin M, Jaramillo R, Zeldin DC. National prevalence and exposure risk for mouse allergen in US households. J Allergy Clin Immunol. 2004;113(6):1167–71.PubMed
19.
go back to reference Phipatanakul W, Eggleston PA, Wright EC, Wood RA. Mouse allergen. I. the prevalence of mouse allergen in inner-city homes. The National Cooperative Inner-City Asthma Study. J Allergy Clin Immunol. 2000;106(6):1070–4.PubMed Phipatanakul W, Eggleston PA, Wright EC, Wood RA. Mouse allergen. I. the prevalence of mouse allergen in inner-city homes. The National Cooperative Inner-City Asthma Study. J Allergy Clin Immunol. 2000;106(6):1070–4.PubMed
20.
go back to reference Matsui EC, Simons E, Rand C, Butz A, Buckley TJ, Breysse P, et al. Airborne mouse allergen in the homes of inner-city children with asthma. J Allergy Clin Immunol. 2005;115(2):358–63.PubMed Matsui EC, Simons E, Rand C, Butz A, Buckley TJ, Breysse P, et al. Airborne mouse allergen in the homes of inner-city children with asthma. J Allergy Clin Immunol. 2005;115(2):358–63.PubMed
21.
go back to reference Matsui EC, Wood RA, Rand C, Kanchanaraksa S, Swartz L, Eggleston PA. Mouse allergen exposure and mouse skin test sensitivity in suburban, middle-class children with asthma. J Allergy Clin Immunol. 2004;113(5):910–5.PubMed Matsui EC, Wood RA, Rand C, Kanchanaraksa S, Swartz L, Eggleston PA. Mouse allergen exposure and mouse skin test sensitivity in suburban, middle-class children with asthma. J Allergy Clin Immunol. 2004;113(5):910–5.PubMed
22.
go back to reference Perry T, Matsui E, Merriman B, Duong T, Eggleston P. The prevalence of rat allergen in inner-city homes and its relationship to sensitization and asthma morbidity. J Allergy Clin Immunol. 2003;112(2):346–52.PubMed Perry T, Matsui E, Merriman B, Duong T, Eggleston P. The prevalence of rat allergen in inner-city homes and its relationship to sensitization and asthma morbidity. J Allergy Clin Immunol. 2003;112(2):346–52.PubMed
23.
go back to reference Ahluwalia SK, Peng RD, Breysse PN, Diette GB, Curtin-Brosnan J, Aloe C, et al. Mouse allergen is the major allergen of public health relevance in Baltimore City. J Allergy Clin Immunol. 2013;132(4):830–5 e1–2.PubMed Ahluwalia SK, Peng RD, Breysse PN, Diette GB, Curtin-Brosnan J, Aloe C, et al. Mouse allergen is the major allergen of public health relevance in Baltimore City. J Allergy Clin Immunol. 2013;132(4):830–5 e1–2.PubMed
24.
go back to reference • Grant T, Aloe C, Perzanowski M, Phipatanakul W, Bollinger ME, Miller R, et al. Mouse sensitization and exposure are associated with asthma severity in urban children. J Allergy Clin Immunol Pract. 2017;5(4):1008–14 e1 Mouse sensitization and exposure independently associated with asthma severity, reflected by treatment step and CASI score. • Grant T, Aloe C, Perzanowski M, Phipatanakul W, Bollinger ME, Miller R, et al. Mouse sensitization and exposure are associated with asthma severity in urban children. J Allergy Clin Immunol Pract. 2017;5(4):1008–14 e1 Mouse sensitization and exposure independently associated with asthma severity, reflected by treatment step and CASI score.
25.
go back to reference Matsui EC, Eggleston PA, Buckley TJ, Krishnan JA, Breysse PN, Rand CS, et al. Household mouse allergen exposure and asthma morbidity in inner-city preschool children. Ann Allergy Asthma Immunol. 2006;97(4):514–20.PubMed Matsui EC, Eggleston PA, Buckley TJ, Krishnan JA, Breysse PN, Rand CS, et al. Household mouse allergen exposure and asthma morbidity in inner-city preschool children. Ann Allergy Asthma Immunol. 2006;97(4):514–20.PubMed
26.
go back to reference •• Sheehan WJ, Permaul P, Petty CR, Coull BA, Baxi SN, Gaffin JM, et al. Association between allergen exposure in inner-city schools and asthma morbidity among students. JAMA Pediatr. 2017;171(1):31–8 Exposure to mouse allergen in school associated with increased asthma symptoms and decreased lung function. PubMedPubMedCentral •• Sheehan WJ, Permaul P, Petty CR, Coull BA, Baxi SN, Gaffin JM, et al. Association between allergen exposure in inner-city schools and asthma morbidity among students. JAMA Pediatr. 2017;171(1):31–8 Exposure to mouse allergen in school associated with increased asthma symptoms and decreased lung function. PubMedPubMedCentral
27.
go back to reference Phipatanakul W, Matsui E, Portnoy J, Williams PB, Barnes C, Kennedy K, et al. Environmental assessment and exposure reduction of rodents: a practice parameter. Ann Allergy Asthma Immunol. 2012;109(6):375–87.PubMedPubMedCentral Phipatanakul W, Matsui E, Portnoy J, Williams PB, Barnes C, Kennedy K, et al. Environmental assessment and exposure reduction of rodents: a practice parameter. Ann Allergy Asthma Immunol. 2012;109(6):375–87.PubMedPubMedCentral
28.
go back to reference Pongracic JA, Visness CM, Gruchalla RS, Evans R 3rd, Mitchell HE. Effect of mouse allergen and rodent environmental intervention on asthma in inner-city children. Ann Allergy Asthma Immunol. 2008;101(1):35–41.PubMed Pongracic JA, Visness CM, Gruchalla RS, Evans R 3rd, Mitchell HE. Effect of mouse allergen and rodent environmental intervention on asthma in inner-city children. Ann Allergy Asthma Immunol. 2008;101(1):35–41.PubMed
29.
go back to reference •• Matsui EC, Perzanowski M, Peng RD, Wise RA, Balcer-Whaley S, Newman M, et al. Effect of an integrated pest management intervention on asthma symptoms among mouse-sensitized children and adolescents with asthma: a randomized clinical trial. JAMA. 2017;317(10):1027–36 Although environmental intervention did not result in significant difference compared to control, study demonstrated that a 90% reduction in mouse allergen level was associated with fewer acute care visits and hospitalizations. PubMedPubMedCentral •• Matsui EC, Perzanowski M, Peng RD, Wise RA, Balcer-Whaley S, Newman M, et al. Effect of an integrated pest management intervention on asthma symptoms among mouse-sensitized children and adolescents with asthma: a randomized clinical trial. JAMA. 2017;317(10):1027–36 Although environmental intervention did not result in significant difference compared to control, study demonstrated that a 90% reduction in mouse allergen level was associated with fewer acute care visits and hospitalizations. PubMedPubMedCentral
30.
go back to reference Eggleston PA, Rosenstreich D, Lynn H, Gergen P, Baker D, Kattan M, et al. Relationship of indoor allergen exposure to skin test sensitivity in inner-city children with asthma. J Allergy Clin Immunol. 1998;102(4 Pt 1):563–70.PubMed Eggleston PA, Rosenstreich D, Lynn H, Gergen P, Baker D, Kattan M, et al. Relationship of indoor allergen exposure to skin test sensitivity in inner-city children with asthma. J Allergy Clin Immunol. 1998;102(4 Pt 1):563–70.PubMed
31.
go back to reference Matsui EC, Wood RA, Rand C, Kanchanaraksa S, Swartz L, Curtin-Brosnan J, et al. Cockroach allergen exposure and sensitization in suburban middle-class children with asthma. J Allergy Clin Immunol. 2003;112(1):87–92.PubMed Matsui EC, Wood RA, Rand C, Kanchanaraksa S, Swartz L, Curtin-Brosnan J, et al. Cockroach allergen exposure and sensitization in suburban middle-class children with asthma. J Allergy Clin Immunol. 2003;112(1):87–92.PubMed
32.
go back to reference Kitch BT, Chew G, Burge HA, Muilenberg ML, Weiss ST, Platts-Mills TA, et al. Socioeconomic predictors of high allergen levels in homes in the greater Boston area. Environ Health Perspect. 2000;108(4):301–7.PubMedPubMedCentral Kitch BT, Chew G, Burge HA, Muilenberg ML, Weiss ST, Platts-Mills TA, et al. Socioeconomic predictors of high allergen levels in homes in the greater Boston area. Environ Health Perspect. 2000;108(4):301–7.PubMedPubMedCentral
33.
go back to reference Pomes A, Mueller GA, Randall TA, Chapman MD, Arruda LK. New insights into cockroach allergens. Curr Allergy Asthma Rep. 2017;17(4):25.PubMedPubMedCentral Pomes A, Mueller GA, Randall TA, Chapman MD, Arruda LK. New insights into cockroach allergens. Curr Allergy Asthma Rep. 2017;17(4):25.PubMedPubMedCentral
34.
go back to reference Rosenstreich DL, Eggleston P, Kattan M, Baker D, Slavin RG, Gergen P, et al. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N Engl J Med. 1997;336(19):1356–63.PubMed Rosenstreich DL, Eggleston P, Kattan M, Baker D, Slavin RG, Gergen P, et al. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N Engl J Med. 1997;336(19):1356–63.PubMed
35.
go back to reference Svendsen ER, Gonzales M, Commodore A. The role of the indoor environment: residential determinants of allergy, asthma and pulmonary function in children from a US-Mexico border community. Sci Total Environ. 2018;616–617:1513–23.PubMed Svendsen ER, Gonzales M, Commodore A. The role of the indoor environment: residential determinants of allergy, asthma and pulmonary function in children from a US-Mexico border community. Sci Total Environ. 2018;616–617:1513–23.PubMed
36.
go back to reference Portnoy J, Chew GL, Phipatanakul W, Williams PB, Grimes C, Kennedy K, et al. Environmental assessment and exposure reduction of cockroaches: a practice parameter. J Allergy Clin Immunol. 2013;132(4):802–8 e1–25.PubMed Portnoy J, Chew GL, Phipatanakul W, Williams PB, Grimes C, Kennedy K, et al. Environmental assessment and exposure reduction of cockroaches: a practice parameter. J Allergy Clin Immunol. 2013;132(4):802–8 e1–25.PubMed
37.
go back to reference Gergen PJ, Mortimer KM, Eggleston PA, Rosenstreich D, Mitchell H, Ownby D, et al. Results of the National Cooperative Inner-City Asthma Study (NCICAS) environmental intervention to reduce cockroach allergen exposure in inner-city homes. J Allergy Clin Immunol. 1999;103(3 Pt 1):501–6.PubMed Gergen PJ, Mortimer KM, Eggleston PA, Rosenstreich D, Mitchell H, Ownby D, et al. Results of the National Cooperative Inner-City Asthma Study (NCICAS) environmental intervention to reduce cockroach allergen exposure in inner-city homes. J Allergy Clin Immunol. 1999;103(3 Pt 1):501–6.PubMed
38.
go back to reference Arbes SJ Jr, Sever M, Archer J, Long EH, Gore JC, Schal C, et al. Abatement of cockroach allergen (Bla g 1) in low-income, urban housing: a randomized controlled trial. J Allergy Clin Immunol. 2003;112(2):339–45.PubMed Arbes SJ Jr, Sever M, Archer J, Long EH, Gore JC, Schal C, et al. Abatement of cockroach allergen (Bla g 1) in low-income, urban housing: a randomized controlled trial. J Allergy Clin Immunol. 2003;112(2):339–45.PubMed
39.
go back to reference Arbes SJ Jr, Sever M, Mehta J, Gore JC, Schal C, Vaughn B, et al. Abatement of cockroach allergens (Bla g 1 and Bla g 2) in low-income, urban housing: month 12 continuation results. J Allergy Clin Immunol. 2004;113(1):109–14.PubMed Arbes SJ Jr, Sever M, Mehta J, Gore JC, Schal C, Vaughn B, et al. Abatement of cockroach allergens (Bla g 1 and Bla g 2) in low-income, urban housing: month 12 continuation results. J Allergy Clin Immunol. 2004;113(1):109–14.PubMed
40.
go back to reference Sever ML, Arbes SJ Jr, Gore JC, Santangelo RG, Vaughn B, Mitchell H, et al. Cockroach allergen reduction by cockroach control alone in low-income urban homes: a randomized control trial. J Allergy Clin Immunol. 2007;120(4):849–55.PubMedPubMedCentral Sever ML, Arbes SJ Jr, Gore JC, Santangelo RG, Vaughn B, Mitchell H, et al. Cockroach allergen reduction by cockroach control alone in low-income urban homes: a randomized control trial. J Allergy Clin Immunol. 2007;120(4):849–55.PubMedPubMedCentral
41.
go back to reference • Rabito FA, Carlson JC, He H, Werthmann D, Schal C. A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children. J Allergy Clin Immunol. 2017;140(2):565–70 Single intervention for cockroach led to cockroach elimination and improved asthma outcomes. PubMed • Rabito FA, Carlson JC, He H, Werthmann D, Schal C. A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children. J Allergy Clin Immunol. 2017;140(2):565–70 Single intervention for cockroach led to cockroach elimination and improved asthma outcomes. PubMed
42.
go back to reference Custovic A, Green R, Fletcher A, Smith A, Pickering CA, Chapman MD, et al. Aerodynamic properties of the major dog allergen Can f 1: distribution in homes, concentration, and particle size of allergen in the air. Am J Respir Crit Care Med. 1997;155(1):94–8.PubMed Custovic A, Green R, Fletcher A, Smith A, Pickering CA, Chapman MD, et al. Aerodynamic properties of the major dog allergen Can f 1: distribution in homes, concentration, and particle size of allergen in the air. Am J Respir Crit Care Med. 1997;155(1):94–8.PubMed
43.
go back to reference Ingram JM, Sporik R, Rose G, Honsinger R, Chapman MD, Platts-Mills TA. Quantitative assessment of exposure to dog (Can f 1) and cat (Fel d 1) allergens: relation to sensitization and asthma among children living in Los Alamos. New Mexico J Allergy Clin Immunol. 1995;96(4):449–56.PubMed Ingram JM, Sporik R, Rose G, Honsinger R, Chapman MD, Platts-Mills TA. Quantitative assessment of exposure to dog (Can f 1) and cat (Fel d 1) allergens: relation to sensitization and asthma among children living in Los Alamos. New Mexico J Allergy Clin Immunol. 1995;96(4):449–56.PubMed
44.
go back to reference Custovic A, Green R, Taggart SC, Smith A, Pickering CA, Chapman MD, et al. Domestic allergens in public places. II: dog (Can f1) and cockroach (Bla g 2) allergens in dust and mite, cat, dog and cockroach allergens in the air in public buildings. Clin Exp Allergy. 1996;26(11):1246–52.PubMed Custovic A, Green R, Taggart SC, Smith A, Pickering CA, Chapman MD, et al. Domestic allergens in public places. II: dog (Can f1) and cockroach (Bla g 2) allergens in dust and mite, cat, dog and cockroach allergens in the air in public buildings. Clin Exp Allergy. 1996;26(11):1246–52.PubMed
45.
go back to reference Custovic A, Fletcher A, Pickering CA, Francis HC, Green R, Smith A, et al. Domestic allergens in public places III: house dust mite, cat, dog and cockroach allergens in British hospitals. Clin Exp Allergy. 1998;28(1):53–9.PubMed Custovic A, Fletcher A, Pickering CA, Francis HC, Green R, Smith A, et al. Domestic allergens in public places III: house dust mite, cat, dog and cockroach allergens in British hospitals. Clin Exp Allergy. 1998;28(1):53–9.PubMed
46.
go back to reference Arlian LG, Neal JS, Morgan MS, Rapp CM, Clobes AL. Distribution and removal of cat, dog and mite allergens on smooth surfaces in homes with and without pets. Ann Allergy Asthma Immunol. 2001;87(4):296–302.PubMed Arlian LG, Neal JS, Morgan MS, Rapp CM, Clobes AL. Distribution and removal of cat, dog and mite allergens on smooth surfaces in homes with and without pets. Ann Allergy Asthma Immunol. 2001;87(4):296–302.PubMed
47.
go back to reference De Lucca SD, O'Meara TJ, Tovey ER. Exposure to mite and cat allergens on a range of clothing items at home and the transfer of cat allergen in the workplace. J Allergy Clin Immunol. 2000;106(5):874–9.PubMed De Lucca SD, O'Meara TJ, Tovey ER. Exposure to mite and cat allergens on a range of clothing items at home and the transfer of cat allergen in the workplace. J Allergy Clin Immunol. 2000;106(5):874–9.PubMed
48.
go back to reference Berge M, Munir AK, Dreborg S. Concentrations of cat (Fel d1), dog (Can f1) and mite (Der f1 and Der p1) allergens in the clothing and school environment of Swedish schoolchildren with and without pets at home. Pediatr Allergy Immunol. 1998;9(1):25–30.PubMed Berge M, Munir AK, Dreborg S. Concentrations of cat (Fel d1), dog (Can f1) and mite (Der f1 and Der p1) allergens in the clothing and school environment of Swedish schoolchildren with and without pets at home. Pediatr Allergy Immunol. 1998;9(1):25–30.PubMed
49.
go back to reference Karlsson AS, Renstrom A. Human hair is a potential source of cat allergen contamination of ambient air. Allergy. 2005;60(7):961–4.PubMed Karlsson AS, Renstrom A. Human hair is a potential source of cat allergen contamination of ambient air. Allergy. 2005;60(7):961–4.PubMed
50.
go back to reference • Gergen PJ, Mitchell HE, Calatroni A, Sever ML, Cohn RD, Salo PM, et al. Sensitization and exposure to pets: the effect on asthma morbidity in the US population. J Allergy Clin Immunol Pract. 2018;6(1):101-7 e2. Exposure to increased levels of cat and dog allergens associated with increased asthma exacerbations in those sensitized. Gergen PJ, Mitchell HE, Calatroni A, Sever ML, Cohn RD, Salo PM, et al. Sensitization and exposure to pets: the effect on asthma morbidity in the US population. J Allergy Clin Immunol Pract. 2018;6(1):101-7 e2. Exposure to increased levels of cat and dog allergens associated with increased asthma exacerbations in those sensitized.
51.
go back to reference Portnoy J, Kennedy K, Sublett J, Phipatanakul W, Matsui E, Barnes C, et al. Environmental assessment and exposure control: a practice parameter--furry animals. Ann Allergy Asthma Immunol. 2012;108(4):223 e1–15.PubMed Portnoy J, Kennedy K, Sublett J, Phipatanakul W, Matsui E, Barnes C, et al. Environmental assessment and exposure control: a practice parameter--furry animals. Ann Allergy Asthma Immunol. 2012;108(4):223 e1–15.PubMed
52.
go back to reference Chen CM, Tischer C, Schnappinger M, Heinrich J. The role of cats and dogs in asthma and allergy--a systematic review. Int J Hyg Environ Health. 2010;213(1):1–31.PubMed Chen CM, Tischer C, Schnappinger M, Heinrich J. The role of cats and dogs in asthma and allergy--a systematic review. Int J Hyg Environ Health. 2010;213(1):1–31.PubMed
53.
go back to reference Ihuoma H, Belgrave DC, Murray CS, Foden P, Simpson A, Custovic A. Cat ownership, cat allergen exposure, and trajectories of sensitization and asthma throughout childhood. J Allergy Clin Immunol. 2018;141(2):820–2 e7.PubMedPubMedCentral Ihuoma H, Belgrave DC, Murray CS, Foden P, Simpson A, Custovic A. Cat ownership, cat allergen exposure, and trajectories of sensitization and asthma throughout childhood. J Allergy Clin Immunol. 2018;141(2):820–2 e7.PubMedPubMedCentral
54.
go back to reference Avner DB, Perzanowski MS, Platts-Mills TA, Woodfolk JA. Evaluation of different techniques for washing cats: quantitation of allergen removed from the cat and the effect on airborne Fel d 1. J Allergy Clin Immunol. 1997;100(3):307–12.PubMed Avner DB, Perzanowski MS, Platts-Mills TA, Woodfolk JA. Evaluation of different techniques for washing cats: quantitation of allergen removed from the cat and the effect on airborne Fel d 1. J Allergy Clin Immunol. 1997;100(3):307–12.PubMed
55.
go back to reference Hodson T, Custovic A, Simpson A, Chapman M, Woodcock A, Green R. Washing the dog reduces dog allergen levels, but the dog needs to be washed twice a week. J Allergy Clin Immunol. 1999;103(4):581–5.PubMed Hodson T, Custovic A, Simpson A, Chapman M, Woodcock A, Green R. Washing the dog reduces dog allergen levels, but the dog needs to be washed twice a week. J Allergy Clin Immunol. 1999;103(4):581–5.PubMed
56.
go back to reference Popplewell EJ, Innes VA, Lloyd-Hughes S, Jenkins EL, Khdir K, Bryant TN, et al. The effect of high-efficiency and standard vacuum-cleaners on mite, cat and dog allergen levels and clinical progress. Pediatr Allergy Immunol. 2000;11(3):142–8.PubMed Popplewell EJ, Innes VA, Lloyd-Hughes S, Jenkins EL, Khdir K, Bryant TN, et al. The effect of high-efficiency and standard vacuum-cleaners on mite, cat and dog allergen levels and clinical progress. Pediatr Allergy Immunol. 2000;11(3):142–8.PubMed
57.
go back to reference van der Heide S, van Aalderen WM, Kauffman HF, Dubois AE, de Monchy JG. Clinical effects of air cleaners in homes of asthmatic children sensitized to pet allergens. J Allergy Clin Immunol. 1999;104(2 Pt 1):447–51.PubMed van der Heide S, van Aalderen WM, Kauffman HF, Dubois AE, de Monchy JG. Clinical effects of air cleaners in homes of asthmatic children sensitized to pet allergens. J Allergy Clin Immunol. 1999;104(2 Pt 1):447–51.PubMed
58.
go back to reference Sulser C, Schulz G, Wagner P, Sommerfeld C, Keil T, Reich A, et al. Can the use of HEPA cleaners in homes of asthmatic children and adolescents sensitized to cat and dog allergens decrease bronchial hyperresponsiveness and allergen contents in solid dust? Int Arch Allergy Immunol. 2009;148(1):23–30.PubMed Sulser C, Schulz G, Wagner P, Sommerfeld C, Keil T, Reich A, et al. Can the use of HEPA cleaners in homes of asthmatic children and adolescents sensitized to cat and dog allergens decrease bronchial hyperresponsiveness and allergen contents in solid dust? Int Arch Allergy Immunol. 2009;148(1):23–30.PubMed
59.
go back to reference Dassonville C, Demattei C, Detaint B, Barral S, Bex-Capelle V, Momas I. Assessment and predictors determination of indoor airborne fungal concentrations in Paris newborn babies’ homes. Environ Res. 2008;108(1):80–5.PubMed Dassonville C, Demattei C, Detaint B, Barral S, Bex-Capelle V, Momas I. Assessment and predictors determination of indoor airborne fungal concentrations in Paris newborn babies’ homes. Environ Res. 2008;108(1):80–5.PubMed
60.
go back to reference Baxi SN, Portnoy JM, Larenas-Linnemann D, Phipatanakul W, Environmental AW. Exposure and health effects of fungi on humans. J Allergy Clin Immunol Pract. 2016;4(3):396–404.PubMedPubMedCentral Baxi SN, Portnoy JM, Larenas-Linnemann D, Phipatanakul W, Environmental AW. Exposure and health effects of fungi on humans. J Allergy Clin Immunol Pract. 2016;4(3):396–404.PubMedPubMedCentral
61.
go back to reference Karvonen AM, Hyvarinen A, Korppi M, Haverinen-Shaughnessy U, Renz H, Pfefferle PI, et al. Moisture damage and asthma: a birth cohort study. Pediatrics. 2015;135(3):e598–606.PubMed Karvonen AM, Hyvarinen A, Korppi M, Haverinen-Shaughnessy U, Renz H, Pfefferle PI, et al. Moisture damage and asthma: a birth cohort study. Pediatrics. 2015;135(3):e598–606.PubMed
62.
go back to reference Quansah R, Jaakkola MS, Hugg TT, Heikkinen SA, Jaakkola JJ. Residential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis. PLoS One. 2012;7(11):e47526.PubMedPubMedCentral Quansah R, Jaakkola MS, Hugg TT, Heikkinen SA, Jaakkola JJ. Residential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis. PLoS One. 2012;7(11):e47526.PubMedPubMedCentral
63.
go back to reference Dannemiller KC, Gent JF, Leaderer BP, Peccia J. Indoor microbial communities: influence on asthma severity in atopic and nonatopic children. J Allergy Clin Immunol. 2016;138(1):76–83 e1.PubMedPubMedCentral Dannemiller KC, Gent JF, Leaderer BP, Peccia J. Indoor microbial communities: influence on asthma severity in atopic and nonatopic children. J Allergy Clin Immunol. 2016;138(1):76–83 e1.PubMedPubMedCentral
64.
go back to reference Pongracic JA, O'Connor GT, Muilenberg ML, Vaughn B, Gold DR, Kattan M, et al. Differential effects of outdoor versus indoor fungal spores on asthma morbidity in inner-city children. J Allergy Clin Immunol. 2010;125(3):593–9.PubMedPubMedCentral Pongracic JA, O'Connor GT, Muilenberg ML, Vaughn B, Gold DR, Kattan M, et al. Differential effects of outdoor versus indoor fungal spores on asthma morbidity in inner-city children. J Allergy Clin Immunol. 2010;125(3):593–9.PubMedPubMedCentral
65.
go back to reference Meng J, Barnes CS, Rosenwasser LJ, Children’s Mercy Center for Environmental H. Identity of the fungal species present in the homes of asthmatic children. Clin Exp Allergy 2012;42(10):1448–1458. Meng J, Barnes CS, Rosenwasser LJ, Children’s Mercy Center for Environmental H. Identity of the fungal species present in the homes of asthmatic children. Clin Exp Allergy 2012;42(10):1448–1458.
66.
go back to reference Gent JF, Kezik JM, Hill ME, Tsai E, Li DW, Leaderer BP. Household mold and dust allergens: exposure, sensitization and childhood asthma morbidity. Environ Res. 2012;118:86–93.PubMedPubMedCentral Gent JF, Kezik JM, Hill ME, Tsai E, Li DW, Leaderer BP. Household mold and dust allergens: exposure, sensitization and childhood asthma morbidity. Environ Res. 2012;118:86–93.PubMedPubMedCentral
67.
go back to reference Salo PM, Arbes SJ Jr, Sever M, Jaramillo R, Cohn RD, London SJ, et al. Exposure to Alternaria alternata in US homes is associated with asthma symptoms. J Allergy Clin Immunol. 2006;118(4):892–8.PubMedPubMedCentral Salo PM, Arbes SJ Jr, Sever M, Jaramillo R, Cohn RD, London SJ, et al. Exposure to Alternaria alternata in US homes is associated with asthma symptoms. J Allergy Clin Immunol. 2006;118(4):892–8.PubMedPubMedCentral
68.
go back to reference Oluwole O, Kirychuk SP, Lawson JA, Karunanayake C, Cockcroft DW, Willson PJ, et al. Indoor mold levels and current asthma among school-aged children in Saskatchewan, Canada. Indoor Air. 2017;27(2):311–9.PubMed Oluwole O, Kirychuk SP, Lawson JA, Karunanayake C, Cockcroft DW, Willson PJ, et al. Indoor mold levels and current asthma among school-aged children in Saskatchewan, Canada. Indoor Air. 2017;27(2):311–9.PubMed
69.
go back to reference Sharpe RA, Bearman N, Thornton CR, Husk K, Osborne NJ. Indoor fungal diversity and asthma: a meta-analysis and systematic review of risk factors. J Allergy Clin Immunol. 2015;135(1):110–22.PubMed Sharpe RA, Bearman N, Thornton CR, Husk K, Osborne NJ. Indoor fungal diversity and asthma: a meta-analysis and systematic review of risk factors. J Allergy Clin Immunol. 2015;135(1):110–22.PubMed
70.
go back to reference Dales RE, Zwanenburg H, Burnett R, Franklin CA. Respiratory health effects of home dampness and molds among Canadian children. Am J Epidemiol. 1991;134(2):196–203.PubMed Dales RE, Zwanenburg H, Burnett R, Franklin CA. Respiratory health effects of home dampness and molds among Canadian children. Am J Epidemiol. 1991;134(2):196–203.PubMed
71.
go back to reference Brunekreef B, Dockery DW, Speizer FE, Ware JH, Spengler JD, Ferris BG. Home dampness and respiratory morbidity in children. Am Rev Respir Dis. 1989;140(5):1363–7.PubMed Brunekreef B, Dockery DW, Speizer FE, Ware JH, Spengler JD, Ferris BG. Home dampness and respiratory morbidity in children. Am Rev Respir Dis. 1989;140(5):1363–7.PubMed
72.
go back to reference Weinmayr G, Gehring U, Genuneit J, Buchele G, Kleiner A, Siebers R, et al. Dampness and moulds in relation to respiratory and allergic symptoms in children: results from phase two of the international study of asthma and allergies in childhood (ISAAC phase two). Clin Exp Allergy. 2013;43(7):762–74.PubMed Weinmayr G, Gehring U, Genuneit J, Buchele G, Kleiner A, Siebers R, et al. Dampness and moulds in relation to respiratory and allergic symptoms in children: results from phase two of the international study of asthma and allergies in childhood (ISAAC phase two). Clin Exp Allergy. 2013;43(7):762–74.PubMed
73.
go back to reference Fisk WJ, Lei-Gomez Q, Mendell MJ. Meta-analyses of the associations of respiratory health effects with dampness and mold in homes. Indoor Air. 2007;17(4):284–96.PubMed Fisk WJ, Lei-Gomez Q, Mendell MJ. Meta-analyses of the associations of respiratory health effects with dampness and mold in homes. Indoor Air. 2007;17(4):284–96.PubMed
74.
go back to reference Sauni R, Verbeek JH, Uitti J, Jauhiainen M, Kreiss K, Sigsgaard T. Remediating buildings damaged by dampness and mould for preventing or reducing respiratory tract symptoms, infections and asthma. Cochrane Database Syst Rev. 2015;2:CD007897. Sauni R, Verbeek JH, Uitti J, Jauhiainen M, Kreiss K, Sigsgaard T. Remediating buildings damaged by dampness and mould for preventing or reducing respiratory tract symptoms, infections and asthma. Cochrane Database Syst Rev. 2015;2:CD007897.
75.
go back to reference Kercsmar CM, Dearborn DG, Schluchter M, Xue L, Kirchner HL, Sobolewski J, et al. Reduction in asthma morbidity in children as a result of home remediation aimed at moisture sources. Environ Health Perspect. 2006;114(10):1574–80.PubMedPubMedCentral Kercsmar CM, Dearborn DG, Schluchter M, Xue L, Kirchner HL, Sobolewski J, et al. Reduction in asthma morbidity in children as a result of home remediation aimed at moisture sources. Environ Health Perspect. 2006;114(10):1574–80.PubMedPubMedCentral
76.
go back to reference Burr ML, Matthews IP, Arthur RA, Watson HL, Gregory CJ, Dunstan FD, et al. Effects on patients with asthma of eradicating visible indoor mould: a randomised controlled trial. Thorax. 2007;62(9):767–72.PubMedPubMedCentral Burr ML, Matthews IP, Arthur RA, Watson HL, Gregory CJ, Dunstan FD, et al. Effects on patients with asthma of eradicating visible indoor mould: a randomised controlled trial. Thorax. 2007;62(9):767–72.PubMedPubMedCentral
77.
go back to reference Bernstein JA, Bobbitt RC, Levin L, Floyd R, Crandall MS, Shalwitz RA, et al. Health effects of ultraviolet irradiation in asthmatic children’s homes. J Asthma. 2006;43(4):255–62.PubMed Bernstein JA, Bobbitt RC, Levin L, Floyd R, Crandall MS, Shalwitz RA, et al. Health effects of ultraviolet irradiation in asthmatic children’s homes. J Asthma. 2006;43(4):255–62.PubMed
78.
go back to reference Strickland MJ, Darrow LA, Klein M, Flanders WD, Sarnat JA, Waller LA, et al. Short-term associations between ambient air pollutants and pediatric asthma emergency department visits. Am J Respir Crit Care Med. 2010;182(3):307–16.PubMedPubMedCentral Strickland MJ, Darrow LA, Klein M, Flanders WD, Sarnat JA, Waller LA, et al. Short-term associations between ambient air pollutants and pediatric asthma emergency department visits. Am J Respir Crit Care Med. 2010;182(3):307–16.PubMedPubMedCentral
79.
go back to reference Silverman RA, Ito K. Age-related association of fine particles and ozone with severe acute asthma in New York City. J Allergy Clin Immunol. 2010;125(2):367–73 e5.PubMed Silverman RA, Ito K. Age-related association of fine particles and ozone with severe acute asthma in New York City. J Allergy Clin Immunol. 2010;125(2):367–73 e5.PubMed
80.
go back to reference Gauderman WJ, Avol E, Gilliland F, Vora H, Thomas D, Berhane K, et al. The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med. 2004;351(11):1057–67.PubMed Gauderman WJ, Avol E, Gilliland F, Vora H, Thomas D, Berhane K, et al. The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med. 2004;351(11):1057–67.PubMed
82.
go back to reference Matsui EC. Environmental exposures and asthma morbidity in children living in urban neighborhoods. Allergy. 2014;69(5):553–8.PubMedPubMedCentral Matsui EC. Environmental exposures and asthma morbidity in children living in urban neighborhoods. Allergy. 2014;69(5):553–8.PubMedPubMedCentral
84.
go back to reference Hulin M, Caillaud D, Annesi-Maesano I. Indoor air pollution and childhood asthma: variations between urban and rural areas. Indoor Air. 2010;20(6):502–14.PubMed Hulin M, Caillaud D, Annesi-Maesano I. Indoor air pollution and childhood asthma: variations between urban and rural areas. Indoor Air. 2010;20(6):502–14.PubMed
85.
go back to reference Simons E, Curtin-Brosnan J, Buckley T, Breysse P, Eggleston PA. Indoor environmental differences between inner city and suburban homes of children with asthma. J Urban Health. 2007;84(4):577–90.PubMedPubMedCentral Simons E, Curtin-Brosnan J, Buckley T, Breysse P, Eggleston PA. Indoor environmental differences between inner city and suburban homes of children with asthma. J Urban Health. 2007;84(4):577–90.PubMedPubMedCentral
86.
go back to reference McCormack MC, Breysse PN, Matsui EC, Hansel NN, Williams D, Curtin-Brosnan J, et al. In-home particle concentrations and childhood asthma morbidity. Environ Health Perspect. 2009;117(2):294–8.PubMed McCormack MC, Breysse PN, Matsui EC, Hansel NN, Williams D, Curtin-Brosnan J, et al. In-home particle concentrations and childhood asthma morbidity. Environ Health Perspect. 2009;117(2):294–8.PubMed
87.
go back to reference Kattan M, Gergen PJ, Eggleston P, Visness CM, Mitchell HE. Health effects of indoor nitrogen dioxide and passive smoking on urban asthmatic children. J Allergy Clin Immunol. 2007;120(3):618–24.PubMed Kattan M, Gergen PJ, Eggleston P, Visness CM, Mitchell HE. Health effects of indoor nitrogen dioxide and passive smoking on urban asthmatic children. J Allergy Clin Immunol. 2007;120(3):618–24.PubMed
88.
go back to reference Hansel NN, Breysse PN, McCormack MC, Matsui EC, Curtin-Brosnan J, Williams DL, et al. A longitudinal study of indoor nitrogen dioxide levels and respiratory symptoms in inner-city children with asthma. Environ Health Perspect. 2008;116(10):1428–32.PubMedPubMedCentral Hansel NN, Breysse PN, McCormack MC, Matsui EC, Curtin-Brosnan J, Williams DL, et al. A longitudinal study of indoor nitrogen dioxide levels and respiratory symptoms in inner-city children with asthma. Environ Health Perspect. 2008;116(10):1428–32.PubMedPubMedCentral
89.
go back to reference Annesi-Maesano I, Hulin M, Lavaud F, Raherison C, Kopferschmitt C, de Blay F, et al. Poor air quality in classrooms related to asthma and rhinitis in primary schoolchildren of the French 6 cities study. Thorax. 2012;67(8):682–8.PubMedPubMedCentral Annesi-Maesano I, Hulin M, Lavaud F, Raherison C, Kopferschmitt C, de Blay F, et al. Poor air quality in classrooms related to asthma and rhinitis in primary schoolchildren of the French 6 cities study. Thorax. 2012;67(8):682–8.PubMedPubMedCentral
90.
go back to reference •• Isiugo K, Jandarov R, Cox J, Ryan P, Newman N, Grinshpun SA, et al. Indoor particulate matter and lung function in children. Sci Total Environ. 2019;663:408–17 Increases in indoor PM associated with decreased lung function. PubMedPubMedCentral •• Isiugo K, Jandarov R, Cox J, Ryan P, Newman N, Grinshpun SA, et al. Indoor particulate matter and lung function in children. Sci Total Environ. 2019;663:408–17 Increases in indoor PM associated with decreased lung function. PubMedPubMedCentral
91.
go back to reference Belanger K, Holford TR, Gent JF, Hill ME, Kezik JM, Leaderer BP. Household levels of nitrogen dioxide and pediatric asthma severity. Epidemiology. 2013;24(2):320–30.PubMedPubMedCentral Belanger K, Holford TR, Gent JF, Hill ME, Kezik JM, Leaderer BP. Household levels of nitrogen dioxide and pediatric asthma severity. Epidemiology. 2013;24(2):320–30.PubMedPubMedCentral
92.
go back to reference Butz AM, Matsui EC, Breysse P, Curtin-Brosnan J, Eggleston P, Diette G, et al. A randomized trial of air cleaners and a health coach to improve indoor air quality for inner-city children with asthma and secondhand smoke exposure. Arch Pediatr Adolesc Med. 2011;165(8):741–8.PubMedPubMedCentral Butz AM, Matsui EC, Breysse P, Curtin-Brosnan J, Eggleston P, Diette G, et al. A randomized trial of air cleaners and a health coach to improve indoor air quality for inner-city children with asthma and secondhand smoke exposure. Arch Pediatr Adolesc Med. 2011;165(8):741–8.PubMedPubMedCentral
93.
go back to reference Liu SH, Liu B, Sanders AP, Saland J, Wilson KM. Secondhand smoke exposure and higher blood pressure in children and adolescents participating in NHANES. Prev Med. 2020;134:106052.PubMed Liu SH, Liu B, Sanders AP, Saland J, Wilson KM. Secondhand smoke exposure and higher blood pressure in children and adolescents participating in NHANES. Prev Med. 2020;134:106052.PubMed
94.
go back to reference Kit BK, Simon AE, Brody DJ, Akinbami LJ. US prevalence and trends in tobacco smoke exposure among children and adolescents with asthma. Pediatrics. 2013;131(3):407–14.PubMed Kit BK, Simon AE, Brody DJ, Akinbami LJ. US prevalence and trends in tobacco smoke exposure among children and adolescents with asthma. Pediatrics. 2013;131(3):407–14.PubMed
95.
go back to reference Chilmonczyk BA, Salmun LM, Megathlin KN, Neveux LM, Palomaki GE, Knight GJ, et al. Association between exposure to environmental tobacco smoke and exacerbations of asthma in children. N Engl J Med. 1993;328(23):1665–9.PubMed Chilmonczyk BA, Salmun LM, Megathlin KN, Neveux LM, Palomaki GE, Knight GJ, et al. Association between exposure to environmental tobacco smoke and exacerbations of asthma in children. N Engl J Med. 1993;328(23):1665–9.PubMed
96.
go back to reference Cunningham J, O'Connor GT, Dockery DW, Speizer FE. Environmental tobacco smoke, wheezing, and asthma in children in 24 communities. Am J Respir Crit Care Med. 1996;153(1):218–24.PubMed Cunningham J, O'Connor GT, Dockery DW, Speizer FE. Environmental tobacco smoke, wheezing, and asthma in children in 24 communities. Am J Respir Crit Care Med. 1996;153(1):218–24.PubMed
97.
go back to reference Behbod B, Sharma M, Baxi R, Roseby R, Webster P. Family and carer smoking control programmes for reducing children’s exposure to environmental tobacco smoke. Cochrane Database Syst Rev. 2018;1:CD001746.PubMed Behbod B, Sharma M, Baxi R, Roseby R, Webster P. Family and carer smoking control programmes for reducing children’s exposure to environmental tobacco smoke. Cochrane Database Syst Rev. 2018;1:CD001746.PubMed
98.
go back to reference Lanphear BP, Hornung RW, Khoury J, Yolton K, Lierl M, Kalkbrenner A. Effects of HEPA air cleaners on unscheduled asthma visits and asthma symptoms for children exposed to secondhand tobacco smoke. Pediatrics. 2011;127(1):93–101.PubMed Lanphear BP, Hornung RW, Khoury J, Yolton K, Lierl M, Kalkbrenner A. Effects of HEPA air cleaners on unscheduled asthma visits and asthma symptoms for children exposed to secondhand tobacco smoke. Pediatrics. 2011;127(1):93–101.PubMed
99.
go back to reference Permaul P, Hoffman E, Fu C, Sheehan W, Baxi S, Gaffin J, et al. Allergens in urban schools and homes of children with asthma. Pediatr Allergy Immunol. 2012;23(6):543–9.PubMedPubMedCentral Permaul P, Hoffman E, Fu C, Sheehan W, Baxi S, Gaffin J, et al. Allergens in urban schools and homes of children with asthma. Pediatr Allergy Immunol. 2012;23(6):543–9.PubMedPubMedCentral
100.
go back to reference Kanchongkittiphon W, Sheehan WJ, Friedlander J, Chapman MD, King EM, Martirosyan K, et al. Allergens on desktop surfaces in preschools and elementary schools of urban children with asthma. Allergy. 2014;69(7):960–3.PubMedPubMedCentral Kanchongkittiphon W, Sheehan WJ, Friedlander J, Chapman MD, King EM, Martirosyan K, et al. Allergens on desktop surfaces in preschools and elementary schools of urban children with asthma. Allergy. 2014;69(7):960–3.PubMedPubMedCentral
101.
go back to reference Abramson SL, Turner-Henson A, Anderson L, Hemstreet MP, Bartholomew LK, Joseph CL, et al. Allergens in school settings: results of environmental assessments in 3 city school systems. J Sch Health. 2006;76(6):246–9.PubMedPubMedCentral Abramson SL, Turner-Henson A, Anderson L, Hemstreet MP, Bartholomew LK, Joseph CL, et al. Allergens in school settings: results of environmental assessments in 3 city school systems. J Sch Health. 2006;76(6):246–9.PubMedPubMedCentral
102.
go back to reference Perzanowski MS, Ronmark E, Nold B, Lundback B, Platts-Mills TA. Relevance of allergens from cats and dogs to asthma in the northernmost province of Sweden: schools as a major site of exposure. J Allergy Clin Immunol. 1999;103(6):1018–24.PubMed Perzanowski MS, Ronmark E, Nold B, Lundback B, Platts-Mills TA. Relevance of allergens from cats and dogs to asthma in the northernmost province of Sweden: schools as a major site of exposure. J Allergy Clin Immunol. 1999;103(6):1018–24.PubMed
103.
go back to reference Almqvist C, Wickman M, Perfetti L, Berglind N, Renstrom A, Hedren M, et al. Worsening of asthma in children allergic to cats, after indirect exposure to cat at school. Am J Respir Crit Care Med. 2001;163(3 Pt 1):694–8.PubMed Almqvist C, Wickman M, Perfetti L, Berglind N, Renstrom A, Hedren M, et al. Worsening of asthma in children allergic to cats, after indirect exposure to cat at school. Am J Respir Crit Care Med. 2001;163(3 Pt 1):694–8.PubMed
104.
go back to reference Fernandez-Caldas E, Codina R, Ledford DK, Trudeau WL, Lockey RF. House dust mite, cat, and cockroach allergen concentrations in daycare centers in Tampa, Florida. Ann Allergy Asthma Immunol. 2001;87(3):196–200.PubMed Fernandez-Caldas E, Codina R, Ledford DK, Trudeau WL, Lockey RF. House dust mite, cat, and cockroach allergen concentrations in daycare centers in Tampa, Florida. Ann Allergy Asthma Immunol. 2001;87(3):196–200.PubMed
105.
go back to reference Baxi SN, Muilenberg ML, Rogers CA, Sheehan WJ, Gaffin J, Permaul P, et al. Exposures to molds in school classrooms of children with asthma. Pediatr Allergy Immunol. 2013;24(7):697–703.PubMedPubMedCentral Baxi SN, Muilenberg ML, Rogers CA, Sheehan WJ, Gaffin J, Permaul P, et al. Exposures to molds in school classrooms of children with asthma. Pediatr Allergy Immunol. 2013;24(7):697–703.PubMedPubMedCentral
106.
go back to reference Simoni M, Cai GH, Norback D, Annesi-Maesano I, Lavaud F, Sigsgaard T, et al. Total viable molds and fungal DNA in classrooms and association with respiratory health and pulmonary function of European schoolchildren. Pediatr Allergy Immunol. 2011;22(8):843–52.PubMed Simoni M, Cai GH, Norback D, Annesi-Maesano I, Lavaud F, Sigsgaard T, et al. Total viable molds and fungal DNA in classrooms and association with respiratory health and pulmonary function of European schoolchildren. Pediatr Allergy Immunol. 2011;22(8):843–52.PubMed
107.
go back to reference Baxi SN, Sheehan WJ, Sordillo JE, Muilenberg ML, Rogers CA, Gaffin JM, et al. Association between fungal spore exposure in inner-city schools and asthma morbidity. Ann Allergy Asthma Immunol. 2019;122(6):610–5 e1.PubMedPubMedCentral Baxi SN, Sheehan WJ, Sordillo JE, Muilenberg ML, Rogers CA, Gaffin JM, et al. Association between fungal spore exposure in inner-city schools and asthma morbidity. Ann Allergy Asthma Immunol. 2019;122(6):610–5 e1.PubMedPubMedCentral
108.
go back to reference Chen CH, Chao HJ, Chan CC, Chen BY, Guo YL. Current asthma in schoolchildren is related to fungal spores in classrooms. Chest. 2014;146(1):123–34.PubMed Chen CH, Chao HJ, Chan CC, Chen BY, Guo YL. Current asthma in schoolchildren is related to fungal spores in classrooms. Chest. 2014;146(1):123–34.PubMed
109.
go back to reference Gaffin JM, Petty CR, Hauptman M, Kang CM, Wolfson JM, Abu Awad Y, et al. Modeling indoor particulate exposures in inner-city school classrooms. J Expo Sci Environ Epidemiol. 2017;27(5):451–7.PubMed Gaffin JM, Petty CR, Hauptman M, Kang CM, Wolfson JM, Abu Awad Y, et al. Modeling indoor particulate exposures in inner-city school classrooms. J Expo Sci Environ Epidemiol. 2017;27(5):451–7.PubMed
110.
go back to reference Carrion-Matta A, Kang CM, Gaffin JM, Hauptman M, Phipatanakul W, Koutrakis P, et al. Classroom indoor PM2.5 sources and exposures in inner-city schools. Environ Int. 2019;131:104968.PubMed Carrion-Matta A, Kang CM, Gaffin JM, Hauptman M, Phipatanakul W, Koutrakis P, et al. Classroom indoor PM2.5 sources and exposures in inner-city schools. Environ Int. 2019;131:104968.PubMed
111.
go back to reference • Gaffin JM, Hauptman M, Petty CR, Sheehan WJ, Lai PS, Wolfson JM, et al. Nitrogen dioxide exposure in school classrooms of inner-city children with asthma. J Allergy Clin Immunol. 2018;141(6):2249–55 e2 Indoor classroom NO2 levels assoiated with increased airflow obstruction. • Gaffin JM, Hauptman M, Petty CR, Sheehan WJ, Lai PS, Wolfson JM, et al. Nitrogen dioxide exposure in school classrooms of inner-city children with asthma. J Allergy Clin Immunol. 2018;141(6):2249–55 e2 Indoor classroom NO2 levels assoiated with increased airflow obstruction.
112.
go back to reference Custovic A, Simpson BM, Simpson A, Hallam C, Craven M, Brutsche M, et al. Manchester asthma and allergy study: low-allergen environment can be achieved and maintained during pregnancy and in early life. J Allergy Clin Immunol. 2000;105(2 Pt 1):252–8.PubMed Custovic A, Simpson BM, Simpson A, Hallam C, Craven M, Brutsche M, et al. Manchester asthma and allergy study: low-allergen environment can be achieved and maintained during pregnancy and in early life. J Allergy Clin Immunol. 2000;105(2 Pt 1):252–8.PubMed
113.
go back to reference Custovic A, Simpson BM, Simpson A, Kissen P, Woodcock A, Asthma NACM, et al. Effect of environmental manipulation in pregnancy and early life on respiratory symptoms and atopy during first year of life: a randomised trial. Lancet. 2001;358(9277):188–93.PubMed Custovic A, Simpson BM, Simpson A, Kissen P, Woodcock A, Asthma NACM, et al. Effect of environmental manipulation in pregnancy and early life on respiratory symptoms and atopy during first year of life: a randomised trial. Lancet. 2001;358(9277):188–93.PubMed
114.
go back to reference Carter MC, Perzanowski MS, Raymond A, Platts-Mills TA. Home intervention in the treatment of asthma among inner-city children. J Allergy Clin Immunol. 2001;108(5):732–7.PubMed Carter MC, Perzanowski MS, Raymond A, Platts-Mills TA. Home intervention in the treatment of asthma among inner-city children. J Allergy Clin Immunol. 2001;108(5):732–7.PubMed
115.
go back to reference Morgan WJ, Crain EF, Gruchalla RS, O'Connor GT, Kattan M, Evans R 3rd, et al. Results of a home-based environmental intervention among urban children with asthma. N Engl J Med. 2004;351(11):1068–80.PubMed Morgan WJ, Crain EF, Gruchalla RS, O'Connor GT, Kattan M, Evans R 3rd, et al. Results of a home-based environmental intervention among urban children with asthma. N Engl J Med. 2004;351(11):1068–80.PubMed
116.
go back to reference Eggleston PA, Butz A, Rand C, Curtin-Brosnan J, Kanchanaraksa S, Swartz L, et al. Home environmental intervention in inner-city asthma: a randomized controlled clinical trial. Ann Allergy Asthma Immunol. 2005;95(6):518–24.PubMed Eggleston PA, Butz A, Rand C, Curtin-Brosnan J, Kanchanaraksa S, Swartz L, et al. Home environmental intervention in inner-city asthma: a randomized controlled clinical trial. Ann Allergy Asthma Immunol. 2005;95(6):518–24.PubMed
117.
go back to reference DiMango E, Serebrisky D, Narula S, Shim C, Keating C, Sheares B, et al. Individualized household allergen intervention lowers allergen level but not asthma medication use: a randomized controlled trial. J Allergy Clin Immunol Pract. 2016;4(4):671–9 e4.PubMedPubMedCentral DiMango E, Serebrisky D, Narula S, Shim C, Keating C, Sheares B, et al. Individualized household allergen intervention lowers allergen level but not asthma medication use: a randomized controlled trial. J Allergy Clin Immunol Pract. 2016;4(4):671–9 e4.PubMedPubMedCentral
118.
go back to reference Le Cann P, Paulus H, Glorennec P, Le Bot B, Frain S, Gangneux JP. Home environmental interventions for the prevention or control of allergic and respiratory diseases: what really works. J Allergy Clin Immunol Pract. 2017;5(1):66–79.PubMed Le Cann P, Paulus H, Glorennec P, Le Bot B, Frain S, Gangneux JP. Home environmental interventions for the prevention or control of allergic and respiratory diseases: what really works. J Allergy Clin Immunol Pract. 2017;5(1):66–79.PubMed
119.
go back to reference Kader R, Kennedy K, Portnoy JM. Indoor environmental interventions and their effect on asthma outcomes. Curr Allergy Asthma Rep. 2018;18(3):17.PubMed Kader R, Kennedy K, Portnoy JM. Indoor environmental interventions and their effect on asthma outcomes. Curr Allergy Asthma Rep. 2018;18(3):17.PubMed
120.
go back to reference Leas BF, D'Anci KE, Apter AJ, Bryant-Stephens T, Lynch MP, Kaczmarek JL, et al. Effectiveness of indoor allergen reduction in asthma management: a systematic review. J Allergy Clin Immunol. 2018;141(5):1854–69.PubMed Leas BF, D'Anci KE, Apter AJ, Bryant-Stephens T, Lynch MP, Kaczmarek JL, et al. Effectiveness of indoor allergen reduction in asthma management: a systematic review. J Allergy Clin Immunol. 2018;141(5):1854–69.PubMed
121.
go back to reference Phipatanakul W, Koutrakis P, Coull BA, Kang CM, Wolfson JM, Ferguson ST, et al. The School Inner-City Asthma Intervention Study: design, rationale, methods, and lessons learned. Contemp Clin Trials. 2017;60:14–23.PubMedPubMedCentral Phipatanakul W, Koutrakis P, Coull BA, Kang CM, Wolfson JM, Ferguson ST, et al. The School Inner-City Asthma Intervention Study: design, rationale, methods, and lessons learned. Contemp Clin Trials. 2017;60:14–23.PubMedPubMedCentral
122.
go back to reference Jhun I, Gaffin JM, Coull BA, Huffaker MF, Petty CR, Sheehan WJ, et al. School environmental intervention to reduce particulate pollutant exposures for children with asthma. J Allergy Clin Immunol Pract. 2017;5(1):154–9 e3.PubMed Jhun I, Gaffin JM, Coull BA, Huffaker MF, Petty CR, Sheehan WJ, et al. School environmental intervention to reduce particulate pollutant exposures for children with asthma. J Allergy Clin Immunol Pract. 2017;5(1):154–9 e3.PubMed
Metadata
Title
The Indoor Environment and Childhood Asthma
Authors
Nicole Akar-Ghibril
Wanda Phipatanakul
Publication date
01-09-2020
Publisher
Springer US
Published in
Current Allergy and Asthma Reports / Issue 9/2020
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-020-00941-5

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