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Irish Journal of Medical Science (1971 -)

Published in:

01-02-2017 | Original Article

The association between MMP2 −1306 C > T (rs243865) polymorphism and risk of prostate cancer

Authors: L. Shajarehpoor Salavati, F. Tafvizi, H. K. Manjili

Published in: Irish Journal of Medical Science (1971 -) | Issue 1/2017

Abstract

Background

Prostate cancer is the second most common cancer in men. Matrix metalloproteinase-2 (MMP2) is the most important member of the matrix metalloproteinase family. MMP2 digests the basement membrane and causes changes in the extracellular matrix which in turn facilitate cancer invasion. It, therefore, has a major role in tumor angiogenesis. Previous studies have identified a single-nucleotide polymorphism C/T at position −1306 of MMP2 gene promoter which is a key regulatory factor in cancer progression.

Aim

The present study aimed to determine the association between MMP2 polymorphism and the risk of prostate cancer in Iranian men.

Methods

This case–control study was performed on 50 paraffin-embedded prostate cancer tissue samples and 54 blood samples from healthy men. Genotyping of the samples was performed using high-resolution melting analysis (HRM). Finally, 20 % of the genotypes were confirmed by sequencing.

Results

No significant associations were found between CT and TT genotypes and the risk of prostate cancer. However, there were no significant relationships between the genotypes and the studied factors, e.g., age, pathological stage, and Gleason Score.

Conclusion

MMP2 −1306 C > T (rs243865) polymorphism was not significantly related with prostate cancer susceptibility in Iranian men.

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Title: The association between MMP2 −1306 C > T (rs243865) polymorphism and risk of prostate cancer
Authors: L. Shajarehpoor Salavati
F. Tafvizi
H. K. Manjili
Publication date: 01-02-2017
Publisher: Springer London
Published in: Irish Journal of Medical Science (1971 -) / Issue 1/2017
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI: https://doi.org/10.1007/s11845-016-1492-9

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The association between MMP2 −1306 C > T (rs243865) polymorphism and risk of prostate cancer

Abstract

Background

Aim

Methods

Results

Conclusion

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Abstract

Background

Aim

Methods

Results

Conclusion

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