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Irish Journal of Medical Science (1971 -)

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Open Access 01-02-2017 | Review Article

From inflammation to cancer

Authors: A. Korniluk, O. Koper, H. Kemona, V. Dymicka-Piekarska

Published in: Irish Journal of Medical Science (1971 -) | Issue 1/2017

Abstract

Background

The participation of inflammation in the progression of cancer for many years have been the subject of research.

Methods

In the 19th century, there was evidence that an acute inflammation may inhibit the development of cancer. However, chronic inflammation affects the progression of the disease.

Results

Today, it is known that inflammation and cancer use similar mechanisms of development such as severe cell proliferation or angiogenesis. It has been shown that prolonged presence of inflammatory cells and factors in the tumor microenvironment can accelerate its growth and inhibit apoptosis of transformed cells.

Conclusion

In this article we present a brief history of the discovery mechanisms and potential links between acute and chronic inflammation and cancer.

Virchov R (1863) Cellular pathology as based upon physiological and pathological histology. J. B. Lippincott, Philadelphia. doi:10.5962/bhl.title.32770

Dvorak HF (1986) Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315:1650–1659. doi:10.1056/NEJM198612253152606 CrossRefPubMed

Trinchieri G (2011) Inflammation in Cancer: a therapeutic target? Oncology (Williston Park) 25:418–420. doi:10.1016/S1470-2045(11)70203-0

Kołaczkowska E (2007) Acute inflammation as a beneficial process—history and recent developments. Kosmos 56:27–38

Scott A, Khan KM, Cook JL et al (2004) What is “inflammation”? Are we ready to move beyond Celsus? Br J Sports Med 38:248–249. doi:10.1136/bjsm.2003.011221 CrossRefPubMedPubMedCentral

Granger DN, Senchenkova E (2010) Historical perspectives. In: Inflammation and the microcirculation, Chapt. 2. Morgan & Claypool Life Sciences, San Rafael (CA), pp 3–6. doi:10.4199/C00013ED1V01Y201006ISP008

Ley K (2001) History of inflammation research. In: Physiology of inflammation. Methods in Physiology Series, Chapt. 1, Oxford University Press, pp 1–10. doi:10.1007/978-1-4614-7512-5

Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140:883–899. doi:10.1016/j.cell.2010.01.025 CrossRefPubMedPubMedCentral

Dmitrieva OS, Shilovskiy IP, Khaitov MR et al (2016) Interleukins 1 and 6 as main mediators of inflammation and cancer. Biochemistry 81:80–90. doi:10.1134/S0006297916020024 PubMed

10.

Zarbock A, Ley K, McEver RP et al (2011) Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow. Blood 118:6743–6751. doi:10.1182/blood-2011-07-343566 CrossRefPubMedPubMedCentral

11.

Wedepohl S, Beceren-Braun F, Riese S et al (2012) L-selectin-a dynamic regulator of leukocyte migration. Eur J Cell Biol 91:257–264. doi:10.1016/j.ejcb.2011.02.007 CrossRefPubMed

12.

Mann AP, Tanaka T (2011) E-selectin: its role in cancer and potential as a biomarker. Transl Med Surg 1:002. doi:10.4172/2161-1025.S1-200

13.

Muller WA (2013) Getting leukocytes to the site of inflammation. Vet Pathol 50:7–22. doi:10.1177/0300985812469883 CrossRefPubMedPubMedCentral

14.

Zarbock A, Kempf T, Wollert KC et al (2012) Leukocyte integrin activation and deactivation: novel mechanisms of balancing inflammation. J Mol Med 90:353–359. doi:10.1007/s00109-011-0835-2 CrossRefPubMed

15.

Kim M, Carman CV, Springer TA (2003) Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 301:1720–1725. doi:10.1126/science.1084174 CrossRefPubMed

16.

Mitroulis I, Alexaki VI, Kourtzelis I et al (2015) Leukocyte integrins: role in leukocyte recruitment and as therapeutic targets in inflammatory disease. Pharmacol Ther 147:123–135. doi:10.1016/j.pharmthera.2014.11.008 CrossRefPubMed

17.

Sumagin R, Sarelius IH (2010) Intercellular adhesion molecule-1 enrichment near tricellular endothelial junctions is preferentially associated with leukocyte transmigration and signals for reorganization of these junctions to accommodate leukocyte passage. J Immunol 184:5242–5252. doi:10.4049/jimmunol.0903319 CrossRefPubMedPubMedCentral

18.

Schenkel AR, Mamdouh Z, Muller WA (2004) Locomotion of monocytes on endothelium is a critical step during extravasation. Nat Immunol 5:393–400. doi:10.1038/ni1051 CrossRefPubMed

19.

Woodfin A, Voisin MB, Beyrau M et al (2011) The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo. Nat Immunol 12:761–769. doi:10.1038/ni2062 CrossRefPubMedPubMedCentral

20.

Muller WA (2007) PECAM: Regulating the start of diapedesis. In: Adhesion molecules: function and inhibition. Progress in inflammation research, pp 201–220. doi:10.1007/978-3-7643-7975-9-8

21.

Ley K, Laudanna C, Cybulsky MI et al (2007) Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol 7:678–689. doi:10.1038/nri2156 CrossRefPubMed

22.

Bixel MG, Li H, Petri B et al (2010) CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis. Blood 116:1172–1184. doi:10.1182/blood-2009-12-256388 CrossRefPubMed

23.

Proebstl D, Voisin MB, Woodfin A et al (2012) Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med 209:1219–1234. doi:10.1084/jem.20111622 CrossRefPubMedPubMedCentral

24.

Nagata M (2005) Inflammatory cells and oxygen radicals. Curr Drug Targets Inflamm 4:503–504. doi:10.2174/1568010054526322 CrossRef

25.

Kolaczkowska E, Kubes P (2013) Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol 13:159–175. doi:10.1038/nri3399 CrossRefPubMed

26.

Crusz SM, Balkwill FR (2015) Inflammation and cancer: advances and new agents. Nat Rev Clin Oncol 12:584–596. doi:10.1038/nrclinonc.2015.105 CrossRefPubMed

27.

Aggarwal BB, Sung B (2011) The relationship between inflammation and cancer is analogous to that between fuel and fire. Oncology (Williston Park) 25:414–418

28.

Askeland EJ, Newton MR, O’Donnell MA et al (2012) Bladder cancer immunotherapy: BCG and beyond. Adv Urol 2012:181987. doi:10.1155/2012/181987 CrossRefPubMedPubMedCentral

29.

Salem ML, Attia ZI, Galal SM (2016) Acute inflammation induces immunomodulatory effects on myeloid cells associated with anti-tumor responses in a tumor mouse model. J Adv Res 7:243–253. doi:10.1016/j.jare2015.06.001 CrossRefPubMed

30.

Balkwill FR, Mantovani A (2012) Cancer-related inflammation: common themes and therapeutic opportunities. Semin Cancer Biol 22:33–40. doi:10.1016/j.semcancer.2011.12.005 CrossRefPubMed

31.

Eiró N, Vizoso FJ (2012) Inflammation and cancer. World J Gastrointest Surg 4:62–72. doi:10.4240/wjgs.v4.i3.62 CrossRefPubMedPubMedCentral

32.

Aggarwal BB, Shishodia S, Sandur SK et al (2006) Inflammation and cancer: how hot is the link? Biochem Pharmacol 72:1605–1621. doi:10.1016/j.bcp.2006.06.029 CrossRefPubMed

33.

Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420:860–867. doi:10.1038/nature01322 CrossRefPubMedPubMedCentral

34.

Mantovani A, Allavena P, Sica A et al (2008) Cancer-related inflammation. Nature 454:436–444. doi:10.1038/nature07205 CrossRefPubMed

35.

Meira LB, Bugni JM, Green SL et al (2008) DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J Clin Invest 118:2516–2525. doi:10.1172/JCI35073 PubMedPubMedCentral

36.

Okazaki IM, Kotani A, Honjo T (2007) Role of AID in tumorigenesis. Adv Immunol 94:245–273. doi:10.1016/S0065-2776(06)94008-5 CrossRefPubMed

37.

Sakurai T, He G, Matsuzawa A et al (2008) Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell 14:156–165. doi:10.1016/j.ccr.2008.06.016 CrossRefPubMedPubMedCentral

38.

Karin M (2006) Nuclear factor-kappaB in cancer development and progression. Nature 441:431–436. doi:10.1038/nature04870 CrossRefPubMed

39.

de Visser KE, Eichten A, Coussens LM (2006) Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 6:24–37. doi:10.1038/nrc1782 CrossRefPubMed

40.

Liang W, Ferrara N (2016) The complex role of neutrophils in tumor angiogenesis and metastasis. Cancer Immunol Res 4:83. doi:10.1158/2326-6066.CIR-15-0313 CrossRefPubMed

Title: From inflammation to cancer
Authors: A. Korniluk
O. Koper
H. Kemona
V. Dymicka-Piekarska
Publication date: 01-02-2017
Publisher: Springer London
Published in: Irish Journal of Medical Science (1971 -) / Issue 1/2017
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI: https://doi.org/10.1007/s11845-016-1464-0

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