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Irish Journal of Medical Science (1971 -)
Published in: Irish Journal of Medical Science (1971 -) 1/2017

01-02-2017 | Original Article

Relationship between leptin concentration and body fat with peripheral blood mononuclear cells cytokines among obese and overweight adults

Authors: M. Zarrati, E. Salehi, E. Razmpoosh, R. S. Shoormasti, M. J. Hosseinzadeh-attar, F. Shidfar

Published in: Irish Journal of Medical Science (1971 -) | Issue 1/2017

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Abstract

Background

Overweight and obesity has been suggested to be well correlated with altered levels of pro-inflammatory cytokines.

Aim

The purpose of this study is to assess the relationship of body fat mass (BFM), body fat percentage (BFP) and leptin levels with peripheral blood mononuclear cells (PBMCs) cytokines among obese and overweight adults.

Methods

Eighty-two overweight and obese individuals were divided into two BMI-category groups (BMI <30 and BMI ≥30 kg/m2) in this study. Balanced blocked randomization was used based on their sex and BMI ranges. Fasting blood samples, PBMCs cytokines, leptin and anthropometric indices were measured and PBMCs were cultured.

Results

Mean of leptin concentrations were 23.14 ± 4.07 and 28.25 ± 4.35 pg/ml among individuals with BMI <30 and BMI ≥30 kg/m2, respectively. The mean values of anthropometric measurements (all P < 0.001), the concentrations of TNF-α (P = 0.028) and IFN-γ (P = 0.029) were significantly higher among obese individuals. BFP had a significant positive correlation with leptin (P < 0.001, r = 0.445) and TGF-β (P = 0.03, r = 0.243). BFM has significant positive correlation with leptin (P < 0.001, r = 0.521). Leptin had a positive significant correlation with IFN-γ (p = 0.03, r = 0.251).

Conclusions

Regarding these results, we proved that BFP, BFM and leptin levels have significant correlations with some PBMC cytokines. Focusing on such strategies may lead to promises for alleviating obesity and its co-morbidities.
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Metadata
Title
Relationship between leptin concentration and body fat with peripheral blood mononuclear cells cytokines among obese and overweight adults
Authors
M. Zarrati
E. Salehi
E. Razmpoosh
R. S. Shoormasti
M. J. Hosseinzadeh-attar
F. Shidfar
Publication date
01-02-2017
Publisher
Springer London
Published in
Irish Journal of Medical Science (1971 -) / Issue 1/2017
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI
https://doi.org/10.1007/s11845-016-1454-2

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Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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