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Published in: Irish Journal of Medical Science (1971 -) 3/2016

01-08-2016 | Original Article

Effect of integrating HIV and addiction care for non-engaging HIV-infected opiate-dependent patients

Authors: J. C. Kinahan, S. Surah, S. Keating, C. Bergin, F. Mulcahy, F. Lyons, E. Keenan

Published in: Irish Journal of Medical Science (1971 -) | Issue 3/2016

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Abstract

Background

HIV-positive substance dependent patients contribute disproportionally to HIV morbidity and mortality as a result of poor compliance with their HIV treatment. For HIV-positive opiate-dependent patients integrating HIV and addiction care improves HIV morbidity but the effect on addiction morbidity is not known.

Aims

This study aims to establish if integrating HIV and addiction care has a significant effect on addiction and HIV morbidity for non-engaging HIV-positive opiate-dependent patients.

Methods

Patients attending the National Drug Treatment Centre who had disengaged from their HIV treatment in St James’s Hospital were recruited to receive HIV care integrated into their methadone maintenance programme. Outcome was investigated in terms of urine toxicology (opiates, cocaine, cannabis and amphetamines); adherence to methadone; proportion receiving directly observed antiretroviral therapy; proportion HIV virally suppressed; and the CD4 cell count.

Results

No significant change in substance use or methadone adherence was demonstrated in the 19 recruited participants. There was a significant increase in the proportion receiving directly observed antiretroviral therapy, and in the CD4 cell count.

Conclusion

Integration of HIV and addiction care optimises the physical health of non-engaging HIV-positive opiate-dependent patients with no substantial effect on their methadone maintenance programme.
Literature
1.
go back to reference Leshner AI (1997) Drug abuse and addiction treatment research. The next generation. Arch Gen Psychiatry 54(8):691–694CrossRefPubMed Leshner AI (1997) Drug abuse and addiction treatment research. The next generation. Arch Gen Psychiatry 54(8):691–694CrossRefPubMed
3.
go back to reference Thompson MA, Aberg JA, Hoy JF et al (2012) Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel. JAMA 308(4):387–402CrossRefPubMed Thompson MA, Aberg JA, Hoy JF et al (2012) Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel. JAMA 308(4):387–402CrossRefPubMed
4.
go back to reference Douaihy AB, Jou RJ, Gorske T et al (2003) Triple diagnosis: dual diagnosis and HIV disease, Part 1. AIDS Read 13(7):331–341PubMed Douaihy AB, Jou RJ, Gorske T et al (2003) Triple diagnosis: dual diagnosis and HIV disease, Part 1. AIDS Read 13(7):331–341PubMed
5.
go back to reference Douaihy AB, Jou RJ, Gorske TETAL (2003) Triple diagnosis: dual diagnosis and HIV disease, part 2. AIDS Read 13(8):375–382PubMed Douaihy AB, Jou RJ, Gorske TETAL (2003) Triple diagnosis: dual diagnosis and HIV disease, part 2. AIDS Read 13(8):375–382PubMed
6.
go back to reference Kuehn BM (2008) Integrated care needed for patients with HIV, drug abuse, and mental illness. JAMA 300(5):494–495CrossRefPubMed Kuehn BM (2008) Integrated care needed for patients with HIV, drug abuse, and mental illness. JAMA 300(5):494–495CrossRefPubMed
7.
go back to reference Wolfe D, Carrieri MP, Shepard D (2010) Treatment and care for injecting drug users with HIV infection: a review of barriers and ways forward. Lancet 376(9738):355–366CrossRefPubMed Wolfe D, Carrieri MP, Shepard D (2010) Treatment and care for injecting drug users with HIV infection: a review of barriers and ways forward. Lancet 376(9738):355–366CrossRefPubMed
8.
go back to reference Bruce RD, Altice FL (2007) Clinical care of the HIV-infected drug user. Infect Dis Clin North Am 21(1):149–179 (ix) Bruce RD, Altice FL (2007) Clinical care of the HIV-infected drug user. Infect Dis Clin North Am 21(1):149–179 (ix)
9.
go back to reference Berg KM, Mouriz J, Li X et al (2009) Rationale, design, and sample characteristics of a randomized controlled trial of directly observed antiretroviral therapy delivered in methadone clinics. Contemp Clin Trials 30(5):481–489CrossRefPubMedPubMedCentral Berg KM, Mouriz J, Li X et al (2009) Rationale, design, and sample characteristics of a randomized controlled trial of directly observed antiretroviral therapy delivered in methadone clinics. Contemp Clin Trials 30(5):481–489CrossRefPubMedPubMedCentral
10.
go back to reference Hart JE, Jeon CY, Ivers LC et al (2010) Effect of directly observed therapy for highly active antiretroviral therapy on virologic, immunologic, and adherence outcomes: a meta-analysis and systematic review. J Acquir Immune Defic Syndr 54(2):167–179PubMedPubMedCentral Hart JE, Jeon CY, Ivers LC et al (2010) Effect of directly observed therapy for highly active antiretroviral therapy on virologic, immunologic, and adherence outcomes: a meta-analysis and systematic review. J Acquir Immune Defic Syndr 54(2):167–179PubMedPubMedCentral
11.
go back to reference Berg KM, Litwin A, Li X et al (2011) Directly observed antiretroviral therapy improves adherence and viral load in drug users attending methadone maintenance clinics: a randomized controlled trial. Drug Alcohol Depend 113(2–3):192–199CrossRefPubMed Berg KM, Litwin A, Li X et al (2011) Directly observed antiretroviral therapy improves adherence and viral load in drug users attending methadone maintenance clinics: a randomized controlled trial. Drug Alcohol Depend 113(2–3):192–199CrossRefPubMed
12.
go back to reference Clarke S, Delamere S, McCullough L et al (2003) Assessing limiting factors to the acceptance of antiretroviral therapy in a large cohort of injecting drug users. HIV Med 4(1):33–37CrossRefPubMed Clarke S, Delamere S, McCullough L et al (2003) Assessing limiting factors to the acceptance of antiretroviral therapy in a large cohort of injecting drug users. HIV Med 4(1):33–37CrossRefPubMed
13.
go back to reference Clarke S, Keenan E, Ryan M (2002) Directly observed antiretroviral therapy for injection drug users with HIV infection. AIDS Read 12(7):305–306PubMed Clarke S, Keenan E, Ryan M (2002) Directly observed antiretroviral therapy for injection drug users with HIV infection. AIDS Read 12(7):305–306PubMed
14.
go back to reference Soto TA, Bell J, Pillen MB (2004) Literature on integrated HIV care: a review. AIDS Care 16(Suppl 1):S43–S55CrossRefPubMed Soto TA, Bell J, Pillen MB (2004) Literature on integrated HIV care: a review. AIDS Care 16(Suppl 1):S43–S55CrossRefPubMed
15.
go back to reference Sylla L, Bruce RD, Kamarulzaman A et al (2007) Integration and co-location of HIV/AIDS, tuberculosis and drug treatment services. Int J Drug Policy 18(4):306–312CrossRefPubMedPubMedCentral Sylla L, Bruce RD, Kamarulzaman A et al (2007) Integration and co-location of HIV/AIDS, tuberculosis and drug treatment services. Int J Drug Policy 18(4):306–312CrossRefPubMedPubMedCentral
17.
go back to reference Preston KL, Umbricht A, Epstein DH (2000) Methadone dose increase and abstinence reinforcement for treatment of continued heroin use during methadone maintenance. Arch Gen Psychiatry 57(4):395–404CrossRefPubMed Preston KL, Umbricht A, Epstein DH (2000) Methadone dose increase and abstinence reinforcement for treatment of continued heroin use during methadone maintenance. Arch Gen Psychiatry 57(4):395–404CrossRefPubMed
18.
go back to reference Dupont WD, Plummer WD Jr (1990) Power and sample size calculations. A review and computer program. Control Clin Trials 11(2):116–128CrossRefPubMed Dupont WD, Plummer WD Jr (1990) Power and sample size calculations. A review and computer program. Control Clin Trials 11(2):116–128CrossRefPubMed
19.
go back to reference Nahvi S, Litwin AH, Heo M et al (2012) Directly observed antiretroviral therapy eliminates adverse effects of active drug use on adherence. Drug Alcohol Depend 120(1–3):174–180CrossRefPubMed Nahvi S, Litwin AH, Heo M et al (2012) Directly observed antiretroviral therapy eliminates adverse effects of active drug use on adherence. Drug Alcohol Depend 120(1–3):174–180CrossRefPubMed
20.
go back to reference De CS, Sabate E (2003) Adherence to heroin dependence therapies and human immunodeficiency virus/acquired immunodeficiency syndrome infection rates among drug abusers. Clin Infect Dis 37(Suppl 5):S464–S467 De CS, Sabate E (2003) Adherence to heroin dependence therapies and human immunodeficiency virus/acquired immunodeficiency syndrome infection rates among drug abusers. Clin Infect Dis 37(Suppl 5):S464–S467
21.
go back to reference Cohen J (1988) Statistical power analysis for the behavioral sciences. 2nd edn. Routledge Cohen J (1988) Statistical power analysis for the behavioral sciences. 2nd edn. Routledge
22.
go back to reference Conway B, Prasad J, Reynolds R et al (2004) Directly observed therapy for the management of HIV-infected patients in a methadone program. Clin Infect Dis 38(Suppl 5):S402–S408CrossRefPubMed Conway B, Prasad J, Reynolds R et al (2004) Directly observed therapy for the management of HIV-infected patients in a methadone program. Clin Infect Dis 38(Suppl 5):S402–S408CrossRefPubMed
23.
go back to reference Luas GM, Weidle PJ, Hader S et al (2004) Directly administered antiretroviral therapy in an urban methadone maintenance clinic: a nonrandomized comparative study. Clin Infect Dis 38(Suppl 5):S409–S4013 Luas GM, Weidle PJ, Hader S et al (2004) Directly administered antiretroviral therapy in an urban methadone maintenance clinic: a nonrandomized comparative study. Clin Infect Dis 38(Suppl 5):S409–S4013
Metadata
Title
Effect of integrating HIV and addiction care for non-engaging HIV-infected opiate-dependent patients
Authors
J. C. Kinahan
S. Surah
S. Keating
C. Bergin
F. Mulcahy
F. Lyons
E. Keenan
Publication date
01-08-2016
Publisher
Springer London
Published in
Irish Journal of Medical Science (1971 -) / Issue 3/2016
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI
https://doi.org/10.1007/s11845-015-1319-0

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