Published in:
Open Access 01-12-2015 | Original Article
Urinary calcium excretion in children with monosymptomatic enuresis
Published in: Irish Journal of Medical Science (1971 -) | Issue 4/2015
Login to get accessAbstract
Background
Among many factors predisposing to monosymptomatic enuresis (MNE) disturbances in urinary electrolites excretion play an important role. Because of many controversies in this field there is a need to debate the role of hypercalciuria in MNE. The aim of our study was to determine the urinary calcium in children with MNE.
Methods
The investigation was conducted on 204 children (83 MNE children and 121 reference group). Urinary calcium excretion (in 24-h collection and per kg of body mass), Ca/creatinine ratio, Ca2+ in urine sample and in 24-h collection of urine were estimated.
Results
Hypercalciuria in MNE group was diagnosed in 18/83 (21.69 %) patients. We found statistically significant differences between children with MNE in Ca2+ in urine sample and 24-h collection and Ca/creat. ratio. Median urinary calcium excretion (mg/kg/24-h and mmol/24-h) was significantly higher in hypercalciuric enuretic patients. The urinary total calcium (mmol/24-h), urinary bound calcium and urinary calcium concentration (mmol/L) demonstrated a significant positive correlation with height, weight and age in reference group but not in MNE group.
Conclusion
Urinary calcium excretion was significantly disturbed and further studies are needed to assess the role of hypercalciuria in the pathogenesis of MNE.