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Irish Journal of Medical Science (1971 -)
Published in: Irish Journal of Medical Science (1971 -) 3/2009

01-09-2009 | Original Article

Serum vascular endothelial growth factor and angiogenesis are related to the prognosis of patients with gastrointestinal stromal tumors

Authors: T. B. Wang, W. S. Qiu, B. Wei, M. H. Deng, H. B. Wei, W. G. Dong

Published in: Irish Journal of Medical Science (1971 -) | Issue 3/2009

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Abstract

Aim

To investigate if serum vascular endothelial growth factor (SVEGF), tissue VEGF and microvessel density (MVD) have any relation to progress and prognosis in gastrointestinal stromal tumors (GIST).

Methods

SVEGF was examined using ELISA. VEGF and MVD were examined using immunohistochemical staining.

Results

The median level of SVEGF was higher in GIST than in controls. A higher level of SVEGF and a positive expression rate of VEGF were obtained in diameter ≥5 cm, mitotic count ≥2/10 high power fields (HPF), recurrence and high risk groups. The MVD of experimental was higher than that of controls. A higher MVD was observed in mitotic count ≥2/10HPF and recurrence groups. The median level of SVEGF was higher in the VEGF positive group than in the controls. The SVEGF presented a relationship with MVD. Factors predicating poor prognosis were SVEGF and VEGF.

Conclusions

SVEGF and VEGF show a correlation with poor prognosis of GIST.
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Metadata
Title
Serum vascular endothelial growth factor and angiogenesis are related to the prognosis of patients with gastrointestinal stromal tumors
Authors
T. B. Wang
W. S. Qiu
B. Wei
M. H. Deng
H. B. Wei
W. G. Dong
Publication date
01-09-2009
Publisher
Springer-Verlag
Published in
Irish Journal of Medical Science (1971 -) / Issue 3/2009
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI
https://doi.org/10.1007/s11845-009-0315-7

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