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Journal of Cancer Survivorship
Published in: Journal of Cancer Survivorship 4/2020

01-08-2020 | Pancreatic Cancer | Review

Physical function in patients with resectable cancer of the pancreas and liver–a systematic review

Authors: Linda O’Neill, Sophie Reynolds, Gráinne Sheill, Emer Guinan, David Mockler, Justin Geoghegan, Kevin Conlon, John V. Reynolds, Juliette Hussey

Published in: Journal of Cancer Survivorship | Issue 4/2020

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Abstract

Purpose

Surgery is the only potentially curative treatment for pancreatic and liver cancer. However, even in high-volume centres, surgical resection is associated with significant morbidity with resultant physical decline. This systematic review explored physical function and its’ implications in the management of resectable cancer of the pancreas and liver.

Methods

EMBASE, Medline OVID, CINAHL, Cochrane Library and Web of Science were searched up to June 2019 using a predefined search strategy. Screening of titles, abstracts, and full texts, data extraction, and risk of bias assessment was performed independently by two reviewers. A third reviewer resolved disagreements by consensus.

Results

Sixteen studies with a total of 1224 participants were included. Heterogeneity of the literature prevented a meta-analysis. Physical function across the pancreatic/liver cancer trajectory has been under investigated. The relationship between physical function and pancreatic/liver cancer resection outcome remains unclear, although anaerobic threshold appears the strongest predictor of postoperative outcomes. Conclusions regarding the impact of rehabilitative interventions on physical function were limited due to risk of bias concerns.

Conclusions

High-quality evidence regarding the implications of physical function in resectable pancreatic and liver cancers is lacking. Well-designed trials are required to examine physical function across the pancreatic/liver cancer continuum and to measure the impact of rehabilitation on physical function.

Implications for Cancer Survivors

As survival rates for pancreatic and liver cancer slowly improve a greater understanding of the impact of these cancers and their treatments on physical function, and the potential impact of rehabilitative interventions for survivors is required.
Appendix
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Metadata
Title
Physical function in patients with resectable cancer of the pancreas and liver–a systematic review
Authors
Linda O’Neill
Sophie Reynolds
Gráinne Sheill
Emer Guinan
David Mockler
Justin Geoghegan
Kevin Conlon
John V. Reynolds
Juliette Hussey
Publication date
01-08-2020
Publisher
Springer US
Published in
Journal of Cancer Survivorship / Issue 4/2020
Print ISSN: 1932-2259
Electronic ISSN: 1932-2267
DOI
https://doi.org/10.1007/s11764-020-00875-x

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