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Internal and Emergency Medicine

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01-11-2020 | Atorvastatin | CE-Research Letter to the Editor

Protective role of statins in COVID 19 patients: importance of pharmacokinetic characteristics rather than intensity of action

Authors: Rosario Rossi, Marisa Talarico, Francesca Coppi, Giuseppe Boriani

Published in: Internal and Emergency Medicine | Issue 8/2020

Excerpt

Dear Editor, …

Zhang W, Zhao Y, Zhang F et al (2020) The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): the experience of immunologists from China. ClinImmunol. https://doi.org/10.1016/j.clim.2020.108393CrossRef

Schönbeck U, Libby P (2004) Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as anti-inflammatory agents? Circulation 109:II-18–II-26CrossRef

Massachusetts General Hospital COVID-19 Treatment Guidance Version 1.0 3/17/2020. Available at: https://medtube.net/infectious-diseases/medical-documents/26086-covid19-treatment-guidelines-by-massachusetts-general-hospital. Accessed March 28, 2020.

Reiner Ž, Hatamipour M, Banach M et al (2020) Statins and the COVID-19 main protease: in silico evidence on direct interaction. Arch Med Sci 16(3):490–496CrossRefPubMedPubMedCentral

Stone NJ, Robinson J, Lichtenstein AH et al (2013) 2013 ACC AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adult: a report of the american college of cardiology/american heart association task force on practice guidelines. J Am CollCardiol 63:2889–2934CrossRef

Wadman M, Couzin-Frankel J, Kaiser J, Matacic C (2020) How does coronavirus kill? Clinicians trace a ferocious rampage through the body, from brain to toes. Science. https://doi.org/10.1126/science.abc3208CrossRefPubMed

Perrella A, Trama U, Bernardi FF et al (2020) Editorial-COVID-19, more than a viral pneumonia. Eur Rev Med Pharmacol Sci 24(9):5183–5185PubMed

Mao L, Jin H, Wang M et al (2020) Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMANeurol 2020:e201127

Cinti S, Graciotti L, Giordano A, Valerio A, Nisoli E (2020) COVID-19 and fat embolism: a hypothesis to explain the severe clinical outcome in people with obesity. Int J Obes. https://doi.org/10.1038/s41366-020-0624-5CrossRef

10.

Rossi R, Coppi F, Talarico M, Boriani G (2020) Protective role of chronic tretment with direct oral anticoagulants in elderly patients affected by interstitial pneumonia in COVID-19 era. Europ J Intern Med. https://doi.org/10.1016/j.ejim.2020.06.006CrossRef

11.

Karbalai Saleh S, Oraii A, Soleimani A et al (2020) The association between cardiac injury and outcomes in hospitalized patients with COVID-19. Intern Emerg Med. https://doi.org/10.1007/s11739-020-02466-1CrossRefPubMedPubMedCentral

12.

Fajgenbaum DC, Rader DJ (2020) Teaching old drugs new tricks: statins for covID-19? Cell Metab 32(2):145–147CrossRefPubMedPubMedCentral

13.

Zhang XJ, Qin JJ, Cheng X et al (2020) In-hospital use of statins is associated with a reduced risk of mortality among individuals with COVID-19. Cell Metab 32(2):176–187.e4CrossRefPubMedPubMedCentral

14.

Castiglione V, Chiriacò M, Emdin M, Taddei S, Vergaro G (2020) Statin therapy in COVID-19 infection. Eur Heart J CardiovascPharmacother. https://doi.org/10.1016/j.cmet.2020.06.015CrossRef

Title: Protective role of statins in COVID 19 patients: importance of pharmacokinetic characteristics rather than intensity of action
Authors: Rosario Rossi
Marisa Talarico
Francesca Coppi
Giuseppe Boriani
Publication date: 01-11-2020
Publisher: Springer International Publishing
Keywords: Atorvastatin
Statins
COVID-19
Published in: Internal and Emergency Medicine / Issue 8/2020
Print ISSN: 1828-0447
Electronic ISSN: 1970-9366
DOI: https://doi.org/10.1007/s11739-020-02504-y

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