Skip to main content
Top
Published in: Obesity Surgery 12/2020

01-12-2020 | Sleeve Gastrectomy | Review

Enhanced Recovery after Surgery (ERAS): a Systematic Review of Randomised Controlled Trials (RCTs) in Bariatric Surgery

Authors: Amilcare Parisi, Jacopo Desiderio, Roberto Cirocchi, Stefano Trastulli

Published in: Obesity Surgery | Issue 12/2020

Login to get access

Abstract

Objective

Our aim was to conduct an up-to-date systematic review of randomised controlled trials (RCTs) to determine the benefits and harms of enhanced recovery after surgery (ERAS) programme in bariatric surgery.

Methods

MEDLINE, Embase, PubMed, CINAHL and the Cochrane Library were searched for RCTs on ERAS versus standard care (SC) until April 2020. The primary endpoint was the length of hospital stay (LOS).

Results

Five RCTs included a total of 610 procedures. ERAS adoption is capable of significantly reducing LOS (MD of − 0.51; 95% CI − 0.92 to − 0.10; P = 0.01) and postoperative nausea and vomiting (PONV) (OR 0.42; 95% CI 0.19 to 0.95; P = 0.04). No significant differences in terms of adverse events and readmissions.

Conclusions

The implementation of ERAS in bariatric surgery produces a significant reduction in LOS and PONV.
Literature
1.
go back to reference Colquitt JL, Pickett K, Loveman E, et al. Surgery for weight loss in adults. Cochrane Database Syst Rev. 2014;8(8):CD003641. Colquitt JL, Pickett K, Loveman E, et al. Surgery for weight loss in adults. Cochrane Database Syst Rev. 2014;8(8):CD003641.
2.
go back to reference Angrisani L, Santonicola A, Iovino P, et al. IFSO worldwide survey 2016: primary, endoluminal, and revisional procedures. Obes Surg. 2018;28(12):3783–94.CrossRef Angrisani L, Santonicola A, Iovino P, et al. IFSO worldwide survey 2016: primary, endoluminal, and revisional procedures. Obes Surg. 2018;28(12):3783–94.CrossRef
3.
go back to reference Cardoso L, Rodrigues D, Gomes L, et al. Short- and long-term mortality after bariatric surgery: a systematic review and meta-analysis. Diabetes Obes Metab. 2017;19(9):1223–32.PubMedCrossRef Cardoso L, Rodrigues D, Gomes L, et al. Short- and long-term mortality after bariatric surgery: a systematic review and meta-analysis. Diabetes Obes Metab. 2017;19(9):1223–32.PubMedCrossRef
4.
go back to reference Longitudinal Assessment of Bariatric Surgery C, Flum DR, Belle SH, et al. Perioperative safety in the longitudinal assessment of bariatric surgery. N Engl J Med. 2009;361(5):445–54.CrossRef Longitudinal Assessment of Bariatric Surgery C, Flum DR, Belle SH, et al. Perioperative safety in the longitudinal assessment of bariatric surgery. N Engl J Med. 2009;361(5):445–54.CrossRef
5.
go back to reference Aminian A, Brethauer SA, Kirwan JP, et al. How safe is metabolic/diabetes surgery? Diabetes Obes Metab. 2015;17(2):198–201.PubMedCrossRef Aminian A, Brethauer SA, Kirwan JP, et al. How safe is metabolic/diabetes surgery? Diabetes Obes Metab. 2015;17(2):198–201.PubMedCrossRef
6.
go back to reference Ljungqvist O, Scott M, Fearon KC. Enhanced recovery after surgery: a review. JAMA surgery. 2017;152(3):292–8.PubMedCrossRef Ljungqvist O, Scott M, Fearon KC. Enhanced recovery after surgery: a review. JAMA surgery. 2017;152(3):292–8.PubMedCrossRef
7.
go back to reference Thorell A, MacCormick AD, Awad S, et al. Guidelines for perioperative care in bariatric surgery: enhanced recovery after surgery (ERAS) society recommendations. World J Surg. 2016;40(9):2065–83.PubMedCrossRef Thorell A, MacCormick AD, Awad S, et al. Guidelines for perioperative care in bariatric surgery: enhanced recovery after surgery (ERAS) society recommendations. World J Surg. 2016;40(9):2065–83.PubMedCrossRef
8.
go back to reference Mannaerts GH, van Mil SR, Stepaniak PS, et al. Results of implementing an enhanced recovery after bariatric surgery (ERABS) protocol. Obes Surg. 2016;26(2):303–12.PubMedCrossRef Mannaerts GH, van Mil SR, Stepaniak PS, et al. Results of implementing an enhanced recovery after bariatric surgery (ERABS) protocol. Obes Surg. 2016;26(2):303–12.PubMedCrossRef
9.
go back to reference Barreca M, Renzi C, Tankel J, et al. Is there a role for enhanced recovery after laparoscopic bariatric surgery? Preliminary results from a specialist obesity treatment center. Surg Obes Relat Dis. 2016;12(1):119–26.PubMedCrossRef Barreca M, Renzi C, Tankel J, et al. Is there a role for enhanced recovery after laparoscopic bariatric surgery? Preliminary results from a specialist obesity treatment center. Surg Obes Relat Dis. 2016;12(1):119–26.PubMedCrossRef
10.
go back to reference Meunier H, Le Roux Y, Fiant AL, et al. Does the implementation of enhanced recovery after surgery (ERAS) guidelines improve outcomes of bariatric surgery? A propensity score analysis in 464 patients. Obes Surg. 2019;29(9):2843–53.PubMedCrossRef Meunier H, Le Roux Y, Fiant AL, et al. Does the implementation of enhanced recovery after surgery (ERAS) guidelines improve outcomes of bariatric surgery? A propensity score analysis in 464 patients. Obes Surg. 2019;29(9):2843–53.PubMedCrossRef
11.
go back to reference Brethauer SA, Grieco A, Fraker T, et al. Employing enhanced recovery goals in bariatric surgery (ENERGY): a national quality improvement project using the metabolic and bariatric surgery accreditation and quality improvement program. Surg Obes Relat Dis. 2019;15(11):1977–89.PubMedCrossRef Brethauer SA, Grieco A, Fraker T, et al. Employing enhanced recovery goals in bariatric surgery (ENERGY): a national quality improvement project using the metabolic and bariatric surgery accreditation and quality improvement program. Surg Obes Relat Dis. 2019;15(11):1977–89.PubMedCrossRef
12.
go back to reference Singh PM, Panwar R, Borle A, et al. Efficiency and safety effects of applying ERAS protocols to bariatric surgery: a systematic review with meta-analysis and trial sequential analysis of evidence. Obes Surg. 2017;27(2):489–501.PubMedCrossRef Singh PM, Panwar R, Borle A, et al. Efficiency and safety effects of applying ERAS protocols to bariatric surgery: a systematic review with meta-analysis and trial sequential analysis of evidence. Obes Surg. 2017;27(2):489–501.PubMedCrossRef
13.
go back to reference Malczak P, Pisarska M, Piotr M, et al. Enhanced recovery after bariatric surgery: systematic review and meta-analysis. Obes Surg. 2017;27(1):226–35.PubMedCrossRef Malczak P, Pisarska M, Piotr M, et al. Enhanced recovery after bariatric surgery: systematic review and meta-analysis. Obes Surg. 2017;27(1):226–35.PubMedCrossRef
14.
go back to reference Ahmed OS, Rogers AC, Bolger JC, et al. Meta-analysis of enhanced recovery protocols in bariatric surgery. J Gastrointest Surg. 2018;22(6):964–72.PubMedCrossRef Ahmed OS, Rogers AC, Bolger JC, et al. Meta-analysis of enhanced recovery protocols in bariatric surgery. J Gastrointest Surg. 2018;22(6):964–72.PubMedCrossRef
15.
go back to reference Lemanu DP, Singh PP, Berridge K, et al. Randomized clinical trial of enhanced recovery versus standard care after laparoscopic sleeve gastrectomy. Br J Surg. 2013;100(4):482–9.PubMedCrossRef Lemanu DP, Singh PP, Berridge K, et al. Randomized clinical trial of enhanced recovery versus standard care after laparoscopic sleeve gastrectomy. Br J Surg. 2013;100(4):482–9.PubMedCrossRef
16.
go back to reference Pimenta GP, Capellan DA, de Aguilar-Nascimento JE. Sleeve gastrectomy with or without a multimodal perioperative care. A randomized pilot study. Obes Surg. 2015;25(9):1639–46.PubMedCrossRef Pimenta GP, Capellan DA, de Aguilar-Nascimento JE. Sleeve gastrectomy with or without a multimodal perioperative care. A randomized pilot study. Obes Surg. 2015;25(9):1639–46.PubMedCrossRef
17.
go back to reference Geubbels N, Evren I, Acherman YIZ, et al. Randomized clinical trial of an enhanced recovery after surgery programme versus conventional care in laparoscopic Roux-en-Y gastric bypass surgery. BJS open. 2019;3(3):274–81.PubMedPubMedCentralCrossRef Geubbels N, Evren I, Acherman YIZ, et al. Randomized clinical trial of an enhanced recovery after surgery programme versus conventional care in laparoscopic Roux-en-Y gastric bypass surgery. BJS open. 2019;3(3):274–81.PubMedPubMedCentralCrossRef
18.
go back to reference Ruiz-Tovar J, Garcia A, Ferrigni C, et al. Impact of implementation of an enhanced recovery after surgery (ERAS) program in laparoscopic Roux-en-Y gastric bypass: a prospective randomized clinical trial. Surg Obes Relat Dis. 2019;15(2):228–35.PubMedCrossRef Ruiz-Tovar J, Garcia A, Ferrigni C, et al. Impact of implementation of an enhanced recovery after surgery (ERAS) program in laparoscopic Roux-en-Y gastric bypass: a prospective randomized clinical trial. Surg Obes Relat Dis. 2019;15(2):228–35.PubMedCrossRef
19.
go back to reference Prabhakaran S, Misra S, Magila M, Kumar SS, Kasthuri S, Palanivelu C, Raj PP. Randomized Controlled Trial Comparing the Outcomes of Enhanced Recovery After Surgery and Standard Recovery Pathways in Laparoscopic Sleeve Gastrectomy. Obes Surg. 2020;30(9):3273-3279 Prabhakaran S, Misra S, Magila M, Kumar SS, Kasthuri S, Palanivelu C, Raj PP. Randomized Controlled Trial Comparing the Outcomes of Enhanced Recovery After Surgery and Standard Recovery Pathways in Laparoscopic Sleeve Gastrectomy. Obes Surg. 2020;30(9):3273-3279
21.
go back to reference Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009;6(7):e1000100.PubMedPubMedCentralCrossRef Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009;6(7):e1000100.PubMedPubMedCentralCrossRef
22.
go back to reference Bhandari M, Fobi MAL, Buchwald JN, Bariatric metabolic surgery standardization working G. Standardization of bariatric metabolic procedures: world consensus meeting statement. Obes Surg 2019;29(Suppl 4):309–345. Bhandari M, Fobi MAL, Buchwald JN, Bariatric metabolic surgery standardization working G. Standardization of bariatric metabolic procedures: world consensus meeting statement. Obes Surg 2019;29(Suppl 4):309–345.
23.
go back to reference Clavien PA, Barkun J, de Oliveira ML, et al. The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg. 2009;250(2):187–96.PubMedCrossRef Clavien PA, Barkun J, de Oliveira ML, et al. The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg. 2009;250(2):187–96.PubMedCrossRef
24.
go back to reference Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17(1):1–12.PubMedCrossRef Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17(1):1–12.PubMedCrossRef
25.
go back to reference Balasubramanian SP, Wiener M, Alshameeri Z, et al. Standards of reporting of randomized controlled trials in general surgery: can we do better? Ann Surg. 2006;244(5):663–7.PubMedPubMedCentralCrossRef Balasubramanian SP, Wiener M, Alshameeri Z, et al. Standards of reporting of randomized controlled trials in general surgery: can we do better? Ann Surg. 2006;244(5):663–7.PubMedPubMedCentralCrossRef
26.
go back to reference Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22(4):719–48.PubMed Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22(4):719–48.PubMed
27.
go back to reference Greenland S, Robins JM. Estimation of a common effect parameter from sparse follow-up data. Biometrics. 1985;41(1):55–68.PubMedCrossRef Greenland S, Robins JM. Estimation of a common effect parameter from sparse follow-up data. Biometrics. 1985;41(1):55–68.PubMedCrossRef
28.
29.
go back to reference Wan X, Wang W, Liu J, et al. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol. 2014;14:135.PubMedPubMedCentralCrossRef Wan X, Wang W, Liu J, et al. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol. 2014;14:135.PubMedPubMedCentralCrossRef
30.
go back to reference Friedman HP, Goldberg JD. Meta-analysis: an introduction and point of view. Hepatology. 1996;23(4):917–28.PubMedCrossRef Friedman HP, Goldberg JD. Meta-analysis: an introduction and point of view. Hepatology. 1996;23(4):917–28.PubMedCrossRef
31.
go back to reference Day RW, Fielder S, Calhoun J, et al. Incomplete reporting of enhanced recovery elements and its impact on achieving quality improvement. Br J Surg. 2015;102(13):1594–602.PubMedPubMedCentralCrossRef Day RW, Fielder S, Calhoun J, et al. Incomplete reporting of enhanced recovery elements and its impact on achieving quality improvement. Br J Surg. 2015;102(13):1594–602.PubMedPubMedCentralCrossRef
32.
go back to reference Neville A, Lee L, Antonescu I, et al. Systematic review of outcomes used to evaluate enhanced recovery after surgery. Br J Surg. 2014;101(3):159–70.PubMedCrossRef Neville A, Lee L, Antonescu I, et al. Systematic review of outcomes used to evaluate enhanced recovery after surgery. Br J Surg. 2014;101(3):159–70.PubMedCrossRef
33.
go back to reference Greco M, Capretti G, Beretta L, et al. Enhanced recovery program in colorectal surgery: a meta-analysis of randomized controlled trials. World J Surg. 2014;38(6):1531–41.PubMedCrossRef Greco M, Capretti G, Beretta L, et al. Enhanced recovery program in colorectal surgery: a meta-analysis of randomized controlled trials. World J Surg. 2014;38(6):1531–41.PubMedCrossRef
34.
go back to reference Zhuang CL, Ye XZ, Zhang XD, et al. Enhanced recovery after surgery programs versus traditional care for colorectal surgery: a meta-analysis of randomized controlled trials. Dis Colon Rectum. 2013;56(5):667–78.PubMedCrossRef Zhuang CL, Ye XZ, Zhang XD, et al. Enhanced recovery after surgery programs versus traditional care for colorectal surgery: a meta-analysis of randomized controlled trials. Dis Colon Rectum. 2013;56(5):667–78.PubMedCrossRef
35.
go back to reference Aman MW, Stem M, Schweitzer MA, et al. Early hospital readmission after bariatric surgery. Surg Endosc. 2016;30(6):2231–8.PubMedCrossRef Aman MW, Stem M, Schweitzer MA, et al. Early hospital readmission after bariatric surgery. Surg Endosc. 2016;30(6):2231–8.PubMedCrossRef
36.
go back to reference Berger ER, Huffman KM, Fraker T, et al. Prevalence and risk factors for bariatric surgery readmissions: findings from 130,007 admissions in the metabolic and bariatric surgery accreditation and quality improvement program. Ann Surg. 2018;267(1):122–31.PubMedCrossRef Berger ER, Huffman KM, Fraker T, et al. Prevalence and risk factors for bariatric surgery readmissions: findings from 130,007 admissions in the metabolic and bariatric surgery accreditation and quality improvement program. Ann Surg. 2018;267(1):122–31.PubMedCrossRef
37.
go back to reference Groene P, Eisenlohr J, Zeuzem C, Dudok S, Karcz K, Hofmann-Kiefer K. Postoperative nausea and vomiting in bariatric surgery in comparison to non-bariatric gastric surgery. Wideochir Inne Tech Maloinwazyjne. 2019;14(1):90-95 Groene P, Eisenlohr J, Zeuzem C, Dudok S, Karcz K, Hofmann-Kiefer K. Postoperative nausea and vomiting in bariatric surgery in comparison to non-bariatric gastric surgery. Wideochir Inne Tech Maloinwazyjne. 2019;14(1):90-95
38.
go back to reference Suh S, Helm M, Kindel TL, Goldblatt MI, Gould JC, Higgins RM. The impact of nausea on post-operative outcomes in bariatric surgery patients. Surg Endosc. 2020;34(7):3085-3091 Suh S, Helm M, Kindel TL, Goldblatt MI, Gould JC, Higgins RM. The impact of nausea on post-operative outcomes in bariatric surgery patients. Surg Endosc. 2020;34(7):3085-3091
39.
go back to reference Major P, Wysocki M, Torbicz G, et al. Risk factors for prolonged length of hospital stay and readmissions after laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2018;28(2):323–32.PubMedCrossRef Major P, Wysocki M, Torbicz G, et al. Risk factors for prolonged length of hospital stay and readmissions after laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2018;28(2):323–32.PubMedCrossRef
40.
go back to reference Gustafsson UO, Oppelstrup H, Thorell A, et al. Adherence to the ERAS protocol is associated with 5-year survival after colorectal cancer surgery: a retrospective cohort study. World J Surg. 2016;40(7):1741–7.PubMedCrossRef Gustafsson UO, Oppelstrup H, Thorell A, et al. Adherence to the ERAS protocol is associated with 5-year survival after colorectal cancer surgery: a retrospective cohort study. World J Surg. 2016;40(7):1741–7.PubMedCrossRef
41.
go back to reference Malczak P, Wysocki M, Twardowska H, et al. Impact of adherence to the ERAS(R) protocol on short-term outcomes after bariatric surgery. Obes Surg. 2020;30(4):1498–505.PubMedCrossRef Malczak P, Wysocki M, Twardowska H, et al. Impact of adherence to the ERAS(R) protocol on short-term outcomes after bariatric surgery. Obes Surg. 2020;30(4):1498–505.PubMedCrossRef
42.
go back to reference Rubino F, Shukla A, Pomp A, et al. Bariatric, metabolic, and diabetes surgery: what’s in a name? Ann Surg. 2014;259(1):117–22.PubMedCrossRef Rubino F, Shukla A, Pomp A, et al. Bariatric, metabolic, and diabetes surgery: what’s in a name? Ann Surg. 2014;259(1):117–22.PubMedCrossRef
43.
go back to reference Myles PS, Weitkamp B, Jones K, et al. Validity and reliability of a postoperative quality of recovery score: the QoR-40. Br J Anaesth. 2000;84(1):11–5.PubMedCrossRef Myles PS, Weitkamp B, Jones K, et al. Validity and reliability of a postoperative quality of recovery score: the QoR-40. Br J Anaesth. 2000;84(1):11–5.PubMedCrossRef
Metadata
Title
Enhanced Recovery after Surgery (ERAS): a Systematic Review of Randomised Controlled Trials (RCTs) in Bariatric Surgery
Authors
Amilcare Parisi
Jacopo Desiderio
Roberto Cirocchi
Stefano Trastulli
Publication date
01-12-2020
Publisher
Springer US
Published in
Obesity Surgery / Issue 12/2020
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-020-05000-6

Other articles of this Issue 12/2020

Obesity Surgery 12/2020 Go to the issue