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01-01-2021 | Probiotics | Original Contributions

Effects of Probiotics Supplementation on Gastrointestinal Symptoms and SIBO after Roux-en-Y Gastric Bypass: a Prospective, Randomized, Double-Blind, Placebo-Controlled Trial

Authors: Nathalia Ramori Farinha Wagner, Marilia Rizzon Zaparolli Ramos, Ligia de Oliveira Carlos, Magda Rosa Ramos da Cruz, Cesar Augusto Taconeli, Alcides José Branco Filho, Luis Sergio Nassif, Maria Eliana Madalozzo Schieferdecker, Antônio Carlos Ligocki Campos

Published in: Obesity Surgery | Issue 1/2021

Abstract

Bariatric surgery may cause undesirable gastrointestinal symptoms due to anatomical, functional and intestinal microbiota changes.

Purpose

The aim of this study was to evaluate the effect of probiotic supplementation on gastrointestinal symptoms and small intestine bacterial overgrowth (SIBO) in patients after Roux-en-Y gastric bypass (RYGB).

Materials and Methods

This is a prospective, randomized, double-blind, placebo-controlled trial. The patients were randomized into Control Group (CG) (n = 39) and Probiotic Group (PG) (n = 34). The PG received tablets containing Lactobacillus acidophilus and Bifidobaterium lactis (5 billion CFU/strain) for 90 days, and the CG received tablets with starch. Both the Gastric Symptom Rating Scale (GSRS) questionnaire and 3-day food record were answered before surgery (T0) and after 45 days (T1) and 90 days of surgery (T2). At T0 and T2, hydrogen breath test was used to verify the presence of SIBO.

Results

The prevalence of SIBO was similar among times, and the mean score of GSRS responses did not differ between groups at any time. However, PG patients reported less bloating compared to CG, more abdominal pain at T1 (which reduced at T2), more episodes of soft stools and nausea and less hunger pain after surgery, with no reports of urgent episodes to evacuate, even though they consumed more fat than the CG.

Conclusions

The supplementation of L. acidophilus and B. lactis is effective in reducing bloating, but without influencing the development of SIBO in the early postoperative period.

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Title: Effects of Probiotics Supplementation on Gastrointestinal Symptoms and SIBO after Roux-en-Y Gastric Bypass: a Prospective, Randomized, Double-Blind, Placebo-Controlled Trial
Authors: Nathalia Ramori Farinha Wagner
Marilia Rizzon Zaparolli Ramos
Ligia de Oliveira Carlos
Magda Rosa Ramos da Cruz
Cesar Augusto Taconeli
Alcides José Branco Filho
Luis Sergio Nassif
Maria Eliana Madalozzo Schieferdecker
Antônio Carlos Ligocki Campos
Publication date: 01-01-2021
Publisher: Springer US
Keywords: Probiotics
Bariatric Surgery
Bariatric Surgery
Key Symptom
Abdominal Pain
Published in: Obesity Surgery / Issue 1/2021
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-020-04900-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Effects of Probiotics Supplementation on Gastrointestinal Symptoms and SIBO after Roux-en-Y Gastric Bypass: a Prospective, Randomized, Double-Blind, Placebo-Controlled Trial

Abstract

Purpose

Materials and Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Materials and Methods

Results

Conclusions

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