Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Obesity Surgery
Published in: Obesity Surgery 8/2018

01-08-2018 | Review Article

The Effect of Bariatric Surgery on Patients with HIV Infection: a Literature Review

Authors: Khalid Akbari, Robin Som, Marianne Sampson, Syed Hussain Abbas, James Ramus, Greg Jones

Published in: Obesity Surgery | Issue 8/2018

Login to get access

Abstract

Obesity among human immunodeficiency virus (HIV)-infected individuals is on the rise. Bariatric procedures such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) alter the GI tract. Whether this alteration has any impact on the absorption of highly active antiretroviral therapy (HAART), thus affecting HIV disease markers such as CD4 cell count or viral load (VL), is not yet known. We conducted this review to look into the outcomes of bariatric surgery procedures, RYGB, SG and adjustable gastric band (AGB) and its effects on the CD4 cell counts and VL and HAART therapy. A literature search was conducted between January and April 2017, by two independent reviewers, using Pubmed and Google Scholar. The terms ‘bariatric surgery and HIV’, ‘obesity surgery and HIV’, ‘gastric bypass surgery and HIV’, ‘sleeve gastrectomy and HIV’ and ‘gastric band and HIV’ were used to retrieve available research. Of the 49 papers reviewed, only 12 reported the outcomes of patients with HIV undergoing bariatric surgery and were therefore included in this review. Six papers assessed patients undergoing RYGB only (N = 18), 3 papers reported on SG only (N = 18) and 3 papers reported on case mix, including 7 cases of RYGB, 4 cases of SG and 11 cases of AGB. Data is limited; however, based on the available data, bariatric surgery is safe in HIV-infected individuals and does not have any adverse impact on HIV disease progress. Additionally, there was no difference in HIV-related outcomes between SG and RYGB.
Literature
1.
2.
3.
Mahy M, Stover J, Stanecki K, et al. Estimating the impact of antiretroviral therapy: regional and global estimates of life-years gained among adults. J Sex Transm Dis. 2010;86:ii67–71.
4.
Seecheran VK, Giddings SL, Seecheran NA. Acute coronary syndromes in patients with HIV. Coron Artery Dis. 2017;28(2):166–72.CrossRefPubMed
5.
Grinspoon S, Carr A. Cardiovascular risk and body-fat abnormalities in HIV-infected adults. N Engl J Med. 2005;352(1):48–62.CrossRefPubMed
6.
Timmons T, Shen C, Aldrovandi G, et al. Microbial translocation and metabolic and body composition measures in treated and untreated HIV infection. AIDS Res Hum Retrovir. 2014;30(3):272–7.CrossRefPubMed
7.
Fernandez-Real JM, Broch M, Richart C, et al. CD14 monocyte receptor, involved in the inflammatory cascade, and insulin sensitivity. J Clin Endocrinol Metab. 2003;88(4):1780–4.CrossRefPubMed
8.
9.
Hollanda A, Ruiz T, Jimenez A, et al. Patterns of weight loss response following gastric bypass and sleeve gastrectomy. Obes Surg. 2015;25(7):1177–83.CrossRefPubMed
10.
Angrisani L, Santonicola A, Iovino P, et al. Bariatric surgery worldwide 2013. Obes Surg. 2015;25:1822–32.CrossRefPubMed
11.
Silecchia G, Bacci V, Bacci S, et al. Reoperation after laparoscopic adjustable gastric banding: analysis of a cohort of 500 patients with long-term follow-up. Surg Obes Relat Dis. 2008;4:430–6.CrossRefPubMed
12.
Li J-F, Lai D-D, Ni B, et al. Comparison of laparoscopic Roux-en-Y gastric bypass with laparoscopic sleeve gastrectomy for morbid obesity or type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. Can J Surg. 2013;56(6):E158–64.CrossRefPubMedPubMedCentral
13.
Buchwald H, Estok R, Fahrbach K, et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med. 2009;122:248–56.CrossRefPubMed
14.
MacBrayne CE, Blum JD, Kiser JJ. Tenofovir, emtricitabine, and darunavir/ritonavir pharmacokinetics in an HIV-infected patient after Roux-en-Y gastric bypass surgery. Ann Pharmacother. 2014;48(6):816–9.CrossRefPubMed
15.
Michalik DE, Jackson-Alvarez JT, Flores R, et al. Low third-trimester serum levels of lamivudine/zidovudine and lopinavir/ritonavir in an HIV-infected pregnant woman with gastric bypass. J Int Assoc Provid AIDS Care. 2015;14(2):116–9.CrossRefPubMed
16.
Alfa-Wali M, Seechurn S, Ayodeji O, et al. Outcomes of bariatric surgery in human immunodeficiency virus positive individuals: a single center experience. Minerva Chir. 2016;71(4):233–8.PubMed
17.
Seechurn S, Alfa-Wali M, Ayodeji O, et al. Obesity and HIV infection-is there a role for bariatric surgery in treatment? J AIDS Clin Res. 2014;5:402.
18.
Fazylov R, Soto E, Merola S. Laparoscopic gastric bypass surgery in human immunodeficiency virus-infected patients. Surg Obes Relat Dis. 2007;3(6):637–9.CrossRefPubMed
19.
Zivich S, Cauterucci M, Allen S, et al. Long-term virologic outcomes following bariatric surgery in patients with HIV. Obes Res Clin Pract. 2015;9:633–5.CrossRefPubMedPubMedCentral
20.
Flanchbaum L, Drake V, Colarusso T, et al. Initial experience with bariatric surgery in asymptomatic human immunodeficiency virus-infected patients. Surg Obes Relat Dis. 2015;1(2):73–6.CrossRef
21.
Selke H, Norris S, Osterholzer D, et al. Bariatric surgery outcomes in HIV-infected subjects: a case series. AIDS Patient Care STDs. 2010;24(9):545–50.CrossRefPubMed
22.
Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. J Am Med Assoc. 2004;292:1724–37.CrossRef
23.
Ikramuddin S, Korner J, Lee WJ, et al. Roux-en-Y gastric bypass vs intensive medical management for the control of type 2 diabetes, hypertension, and hyperlipidemia: the diabetes surgery study randomized clinical trial. JAMA. 2013;309:2240–9.CrossRefPubMedPubMedCentral
24.
Dixon JB, O’Brien PE. Lipid profile in the severely obese: changes with weight loss after lap-band surgery. Obes Res. 2002;10:903–10.CrossRefPubMed
25.
Tran HS, Moncure M, Tarnoff M, et al. Predictors of operative outcome in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. Am J Surg. 2000;180(3):228–33.CrossRefPubMed
26.
Xia XJ, Liu BC, Su JS, et al. Preoperative CD4 count or CD4/CD8 ratio as a useful indicator for postoperative sepsis in HIV-infected patients undergoing abdominal operations. J Surg Res. 2012;174(1):e25–30.CrossRefPubMed
27.
Saltzman DJ, Williams RA, Gelfand DV, et al. The surgeon and AIDS: twenty years later. Arch Surg. 2005;140(10):961–7.CrossRefPubMed
28.
Chichom-Mefire A, Azabji-Kenfack M, Atashili J. CD4 count is still a valid Indicator of outcome in HIV-infected patients undergoing major abdominal surgery in the era of highly active antiretroviral therapy. World J Surg. 2015;39(7):1692–9.CrossRefPubMed
29.
Patrick L. Nutrients and HIV: part two--vitamins a and E, zinc, B-vitamins, and magnesium. Altern Med Rev. 2000;5(1):39–51.PubMed
30.
Baum MK, Shor-Posner G, Lu Y, et al. Micronutrients and HIV-1 disease progression. AIDS. 1995;9(9):1051–6.CrossRefPubMed
31.
Eddy F, Elvin S, Sanmani L. Bariatric surgery: an HIV-positive patient’s successful journey. Int J STD AIDS. 2015. Online first.
32.
Fysekidis M, Cohen R, Bekheit M, et al. Sleeve gastrectomy is a safe and efficient procedure in HIV patients with morbid obesity: a case series with results in weight loss, comorbidity evolution, CD4 count, and viral load. Obes Surg. 2015;25(2):229–33.CrossRefPubMed
33.
Pourcher G, Costagliola D, Martinez V. Obesity in HIV-infected patients in France: prevalence and surgical treatment options. J Visc Surg. 2015;152(1):33–7.CrossRefPubMed
34.
Muzard L, Alvarez J-C, Gbedo C, et al. Tenofovir pharmacokinetic after sleeve-gastrectomy in four severely obese patients living with HIV. Obes Res Clin Pract. 2016;11(1):108–13.CrossRefPubMed
35.
Himpens J, Dobbeleir J, Peeters G. Long-term results of laparoscopic sleeve gastrectomy for obesity. Ann Surg. 2010;252:319–24.CrossRefPubMed
36.
DeMaria EJ, Sugerman HJ, Meador JG, et al. High failure rate after laparoscopic adjustable silicone gastric banding for treatment of morbid obesity. Ann Surg. 2001;233(6):809–18.CrossRefPubMedPubMedCentral
37.
Himpens J, Cadière G-B, Bazi M, et al. Long-term outcomes of laparoscopic adjustable gastric banding. Arch Surg. 2011;146(7):802–7.CrossRefPubMed
38.
Shor-Posner G, Campa A, Zhang G, et al. When obesity is desirable: a longitudinal study of the Miami HIV-1-infected drug abusers (MIDAS) cohort. J Acquir Immune Defic Syndr. 2000;23:81–8.CrossRefPubMed
39.
Jones CY, Hogan JW, Snyder B, et al. Overweight and human immunodeficiency virus (HIV) progression in women: associations HIV disease progression and changes in body mass index in women in the HIV epidemiology research study cohort. Clin Infect Dis. 2003;37(Suppl 2):S69–80.CrossRefPubMed
40.
Matarese G. Leptin and the immune system: how nutritional status influences the immune response. Eur Cytokine Netw. 2000;11:7–14.PubMed
41.
Koethe JR, Jenkins CA, Shepherd BE, et al. An optimal body mass index range associated with improved immune reconstitution among HIV-infected adults initiating antiretroviral therapy. Clin Infect Dis. 2011;53(9):952–60.CrossRefPubMedPubMedCentral
42.
Aman MW, Stem M, Schweitzer MA, et al. Early hospital readmission after bariatric surgery. Surg Endosc 2016;30(6):2231–8.
Metadata
Title
The Effect of Bariatric Surgery on Patients with HIV Infection: a Literature Review
Authors
Khalid Akbari
Robin Som
Marianne Sampson
Syed Hussain Abbas
James Ramus
Greg Jones
Publication date
01-08-2018
Publisher
Springer US
Published in
Obesity Surgery / Issue 8/2018
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-018-3319-4

Other articles of this Issue 8/2018

Obesity Surgery 8/2018 Go to the issue

Original Contributions

Is the Sleeve Gastrectomy Always a Better Procedure? Five-Year Results from a Retrospective Matched Case-Control Study

Biography

Biography: Joel Faintuch, MD, PhD

Review Article

Treatment of Obesity in Young People—a Systematic Review and Meta-analysis

Letter to the Editor

Comments on the Article: The Effects of Laparoscopic Sleeve Gastrectomy with Duodenojejunal Bypass on Japanese Patients with BMI < 35 kg/m2 on Type 2 Diabetes Mellitus and the Prediction of Successful Glycemic Control

Original Contributions

Sleeve Gastrectomy Recovering Disordered Brain Function in Subjects with Obesity: a Longitudinal fMRI Study

Original Contributions

Effectiveness of a Functional Rehabilitation Program After Bariatric Surgery: a Pilot Study